Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, and EAU recommendations.
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Aging↗
Biomedical subjects
W Weidner
Publications and source records attributed to W Weidner.
Semen parameters in men with and without proven chronic prostatitis.
In patients with complaints of chronic prostatitis, analysis of prostatic secretions for leukocytes and the use of the four-specimen technique allow a distinct classification of chronic bacterial (CBP), nonbacterial prostatitis (NBP), and prostatodynia (Pd). In this study, 32 men with CBP, 102 men with NBP, 142 men with Pd, and 42 volunteers, classified as mentioned above, underwent a two-fold ejaculate analysis using WHO criteria. Sperm count, progressive motility, range of abnormal spermatozoa, increased numbers of common bacteria, and peroxidase-positive leukocytes were analyzed. Additionally, antibody-coated bacteria (ACB), numbers of ureaplasmas in semen, and urethral colonization by chlamydia were investigated. Mean values of sperm density, motility, and morphology revealed no differences between the groups. Significant bacteriospermia (greater than or equal to 10(3) bacterial/ml) was evident in only 47% of the CBP group versus 6.8% (NBP), 16% (Pd), and 4.2% (controls). ACB was positive in 31 of 32 men with CBP versus 3 of 102 with NBP, 9 of 142 with Pd, and none of the controls. Increased numbers of leukocytes were evident in CBP and NBP patients compared to the controls (p less than or equal to 0.001) but were also present in patients of the NBP and Pd groups with chlamydial infections.
Adult↗
Concentrations of vasoactive intestinal polypeptide in corpus cavernosum and peripheral venous blood during prostaglandin E1-induced erection.
Vasoactive intestinal polypeptide (VIP) has been suggested to play a role as a nonadrenergic, noncholinergic neurotransmitter or neuromodulator involved in the process of erection. Until now, data about fluctuating concentrations of VIP in corpus cavernosum (CC) blood have been controversial. The present study describes a modified radioimmunoassay method that was developed in our laboratory for the determination of VIP in plasma. Examination of 12 patients suffering from impotentia coeundi (6 men with psychogenic impotence, 2 with induratio penis plastica, and 4 with impotence of vascular origin) showed that the concentrations of VIP in corpus cavernosum blood during pharmacologically induced erection did not increase in organically healthy men or in men with impotentia coeundi of vascular origin. The VIP concentrations in peripheral venous blood and those in CC blood were similar.
Adult↗
In vitro effect of Escherichia coli on human sperm acrosome reaction.
Escherichia coli are known to reduce human sperm motility. The purpose of the present study was to examine whether these bacteria may also affect the acrosome reaction, which is another important sperm function. The acrosome reaction was determined in spermatozoa from 29 fertile men by triple stain after 3-h incubation at 37 degrees C with 2 x 10(6) E. coli/mL or without bacteria (control). Each sample was treated with 0.1% DMSO (spontaneous acrosome reaction) or calcium ionophore A23187 (induced acrosome reaction) for 1 h at 37 degrees C. The inducibility of the acrosome reaction was significantly lower in semen samples pretreated with E. coli than in the control samples (9.8 +/- 4.2% vs. 12.7 +/- 5.3%; p < .05). The results demonstrate that E. coli affect the inducibility of the acrosome reaction in vitro and may impair the fertilizing capacity of human spermatozoa.
Acrosome↗
CD44s, E-cadherin and PCNA as markers for progression in renal cell carcinoma.
CD44s, E-cadherin and PCNA play an important role in the tumorigenesis of renal cell carcinoma (RCC), although their significance in the clinical progression of RCC is still not clear. In n = 137 cases of operatively resected RCC the expression of CD44s, E-cadherin and PCNA was semiquantitatively analyzed by the APAAP immunohistochemical method. The mean observation period of the n = 74 (54%) of patients with no evidence of disease was 52.6 months and for the n = 63 (46%) patients with progressive disease was 18.7 months. The mean progression free period occurring with absent or low levels of CD44s and PCNA expression was 79 and 118+ months, and with strong expression was 12 and 18 months (p < 0.001), respectively. With strong E-cadherin expression the progression free period was 110+ months, and with low expression 61 months (p = 0.01). A high CD44s/E-cadherin ratio and an above average PCNA expression were identified as independent prognostic parameters for the progression tendency of RCC.
Antigens, CD↗
[Inflammatory changes in the urogenital tract and therapeutic possibilities in the course of adjuvant disease in the male rat].
The adjuvant disease of the rat is an experimental disease, not only important as an arthritis model, but also as an "urethritis model" in clinical and therapeutical respects. The polyarthritic syndrome in rats following injection of Freund's adjuvant also shows regularly involvement of the genitourinary system. Urethritis, cavernitis, and balanitis are common inflammatory manifestations of the penis, which can mostly be observed. In the peritesticular and periepididymal fat, granulomata and nonspecific inflammatory reactions do occur. Prostata, bladder, kidneys, testes, and epididymis are seldom involved in the inflammatory process. This therapeutical study demonstrated clearly that acetylsalicylic acid (dosage: 80 mg/kg BW/day) cannot be of benefit for these changes. However, it was possible to significantly influence the inflammatory changes by using prednisolone (dosage: 1.5 mg/kg BW/day).
Animals↗
Use of transrectal ultrasonography of the prostate gland and seminal vesicles in andrology--3 years experience.
Benign and malignant prostatic diseases are very common and give rise to significant morbidity and mortality. The Author describe the technical equipment and the procedure of transrectal ultrasonography introduced for investigation of diseases of the prostate gland and seminal vesicles; ultrasonically guided biopsies give important diagnostic indications not only for the oncologist, but also for the specialist in andrology.
Biopsy, Needle↗
Orbital angiography and venography aided by subtraction technique.
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Adult↗
Quantitative studies on the role of Ureaplasma urealyticum in non-gonococcal urethritis and chronic prostatitis.
Quantitative determinations of U. urealyticum and M. hominis have been performed in 164 men with non-gonococcal urethritis (NGU) and 597 patients with chronic prostatitis. Evidence is provided that U. urealyticum plays an etiologic role in 29.3 percent of patients with non-gonococcal urethritis. Mixed infections of C. trachomatis and U. urealyticum, in high numbers, do occur in 11 percent of NGU cases. A constellation suggesting ureaplasma-associated disease could be observed in 13.7 to 15.2 percent of 597 patients with chronic prostatitis. M. hominis does not appear to be a causative agent of NGU or chronic prostatitis.
Adult↗
[Evidence of bacteria in ejaculate].
Infections caused by bacteria strike primarily the prostate and vesical glands, and secondarily the epididymis. Essential first is to give evidence of bacteria in germ numbers exceeding 10(5) pro ml ejaculate. In addition, the diagnosis of prostatitis requires the demonstration of other signs of infection, for example increased numbers of leukocytes in the ejaculate, in the prostatic secretion and in the urine; the clinical symptoms in relation to these indicators are not necessarily characteristic. It is essential for the microbiological diagnostic, that evidence of all the germs be found in native material. It is therefore necessary to first disinfect the external urethral orifice and the glans penis, in order to avoid super-imposition of germs from the surroundings. Every demonstration of bacteria must be connected with a determination of resistance. The relationships between the ejaculate parameters which deviate from the norm, and evidence of bacteria in ejaculate are unclear. Reports about disturbances in spermatozoa motility or morphology during infections of the adnexa of man are to be evaluated with care.
Bacteria↗
[Ankylosing spondylitis and urogenital infection: diagnosis of urologic infection and correlation with rheumatologic findings].
We examined 134 male patients with confirmed ankylosing spondylitis. The study protocol included a medical-rheumatological examination and thorough exploration for infections of the urinogential tract. An urethroadnexitis was found in 37 of 134 patients (27.6%): Two patients suffered from balanitis, 17 patients from urethritis, 18 patients from prostatitis, and two patients from epididymitis. Only four patients gave a history of urethritis and eight patients of prostatitis. The microorganisms isolated most frequently from patients with urogenital infection were Chlamydia trachomatis and, in few cases, Ureaplasma urealyticum. By comparing the urethroadnexitis group and the non-infected group with regard to other clinical parameters, we found a significantly increased C-reactive protein in the infected group. Other clinical parameters like involvement of the free spinal column, inflammatory involvement of the joints, and HLA-B27 correlation did not differ significantly.
Adolescent↗