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Biomedical subjects

W Wang

Publications and source records attributed to W Wang.

At least 739 records · Page 41Linked to original sources
PubMed1999

[Analysis in pulmonary ventilatory function from 100 patients with ano-rectal diseases caused by deficiency of qi].

OBJECTIVE: To explore the pathogenesis of ano-rectal diseases caused by deficiency of Qi, which is correlated with obstruction of pulmonary ventilation. METHODS: The pulmonary ventilatory function was measured in 100 patients with the internal piles, the interno-external hemorrhoid and prolapse of rectum, the prolapse of anus was the principal symptom of them. RESULTS: Data from the 100 patients showed that 67% of them were diagnosed with the obstruction of pulmonary ventilation, the ratio was far less in the health control group. FEV 1.0 (mean +/- s) (2011.65 +/- 875) ml, MMF (1.84 +/- 1.24) L/s and PEF (2.34 +/- 1.51) L/s in male patients, (1551.54 +/- 514) ml, (1.57 +/- 0.62) L/s and (1.85 +/- 0.92) L/s in female patients, but those values were higher in the control than in the patients. The statistical analysis was performed and the difference was significant between patients and the control group (P < 0.01). CONCLUSION: The patients with ano-rectal diseases caused by deficiency of Qi accompanied with obstruction of pulmonary ventilation in different degree and varied sorts, it confirmed that the pathogenesis of ano-rectal diseases caused by deficiency of Qi is related with "sinking of pectoral Qi".

Adolescent↗
PubMed1999

[The role of detecting bile reflux in the diagnosis of gastroesophageal reflux disease].

OBJECTIVE: To investigate the incidence of esophageal bile reflux and its relationship with acid or alkaline reflux and to evaluate the significance of detecting bile reflux in the diagnosis of gastroesophageal reflux disease (GERD). METHODS: Using ambulatory 24-hour pH monitoring and bilirubin monitoring technique, the changes of 24-hour intraesophageal pH and bile reflux in 34 subjects (including healthy subjects, patients with reflux esophagitis and patients after gastrectomy) were simultaneously assessed. RESULTS: The time of esophageal acid exposure for reflux esophagitis (RE) patients was significantly longer than that in the controls and the patients after gastrectomy, but there was no difference between postgastrectomized patients and healthy controls. Total percent time of pH > 8 in each group was similar and were very low. Bile reflux [duodenogastroesophageal reflux (DGER)], represented by total time percentage of bilirubin absorbance >or=0.14, was greatest in postgastrectomized patients, and next in the patients with RE, but the value in both groups was significantly higher than that in the controls. There was a close association between DGER and total time percentage of pH < 4 (r = 0.75, P < 0.05) but a poor relationship (r = 0.17) with total time percentage pH > 8. 63.6% of the patients with RE had acid and bile reflux simultaneously. CONCLUSION: DGER is common in GERD and postgastrectomized patients. It can occur with acid reflux and may play a role in the development of GERD. It is very important to monitor acid and bile reflux at the same time in the diagnosis of GERD.

Adult↗
PubMed1999

[A retrospective study of 3 cases of nephrotic syndrome with pulmonary thromboembolism].

OBJECTIVE: To study the nephrotic syndrome (NS) with pulmonary thromboembolism (PTE). METHODS: 3 cases of NS with PTE were reviewed. RESULTS: The fibrinogen (mean 7.8 g/L), alpha-2-maccoglobulin (mean 21%) and cholesterol (mean 7.2 mmol/L) in the blood were higher in the NS patients with PTE. 1 of 2 patients was found to be membranous nephropathy. Ventilation/perfusion lung scan and a postmortem examination showed that bilateral, multiple pulmonary thromboembolism was found in 1 case. It was effective to use heparin and/or urokinase for NS with PTE. CONCLUSIONS: NS exists in the hypercoagulable state in blood. It is easy to concomit PTE. Pulmonary artery angiogram should be done when NS with PTE was suspected. Besides glycocorticoids, the combination of anticoagulants and thrombolysis gave most favorable results for NS patients with PTE.

Adult↗
PubMed1999

[A clinical study on vaccine of Mycobacterium vaccae in treating pulmonary tuberculosis].

OBJECTIVE: To study the effect of vaccine of Mycobacterium vaccae on cell-mediated immunity and on treating patients with pulmonary tuberculosis. METHODS: Seventy cases of pulmonary tuberculosis with smear positive and initial treatment were classified randomly into group I (35 cases) and group II (35 cases), receiving 2HRZS/4HR and 2HRZS/4HR plus vaccine of Mycobacterium vaccae regimens respectively. Thirty-one multi-drug resistant pulmonary tuberculosis cases were classified into group III, receiving 4 - 6 sensitive antituberculous drugs and vaccine of Mycobacterium vaccae. Improvement of clinical symptoms, resolution of pulmonary lesions, negative conversion of sputum and changes of immunological functions were observed. RESULTS: No significant difference in improvement of symptoms was found in group I and group II (P > 0.05), and the improvement rate of clinical symptoms in group III was found more than 50%. X-ray resolution rates in 4th month were 83% and 89%, and cavity reducing rates 40% and 50% respectively in group I and group II, and no significant differences were found (P > 0.05). X-ray resolution rate was 29%, cavity reducing rate 7% and no deteriorated case was found in group III. Sputum negative conversion rates in 1st, 2nd, 3rd and 4th month were 23%, 51%, 83% and 97% respectively in group I, while 31%, 77%, 89% and 100% in group II, and 3%, 16%, 29% and 32% in group III. Significant difference was found between group I and group II in sputum negative conversion rate in 2nd month after treatment (P < 0.05). After treatment, values of lymphocyte transformation test (LTT), CD(3), CD(4) and CD(4)/CD(8) of the above 3 groups were all higher than that before the treatment (P < 0.05), level of tumor necrosis factor decreased in group II and IL-2, IL-6 increased in group III. CONCLUSIONS: Vaccine of Mycobacterium vaccae is a good immunotherapy preparation, which promotes sputum negative conversion and activation of cell-mediated immunity.

Adolescent↗
PubMed1999

[The relationship between operation on gastrointestinal cancer and single cells metastasis via portal vein].

OBJECTIVE: To confirm the effect of radical operation on single cells metastasis of gastrointestinal cancer. METHODS: One hundred and seventy two patients with gastrointestinal cancer were divided randomly into group I (111 cases, ordinary operation) and group II (61 cases, operation after ligation of drained vessels). Catheters were inserted into the portal vein during operation. Blood was aspirated and contrifugated. Anti-EMA monoclonal antibody marked the cancer cells, which were shown by ABC immunohistochemical staining. RESULTS: In the examinate group, 72 cases of gastrointestinal cancer were found positive cells among 111 cases (positive rate 64.9%). In the control group, 61 cases were tested and 13 cases were found positive cells (positive rate 21.3%) with a highly significant difference between the two groups (P < 0.005). CONCLUSIONS: Ligating the relative blood vessel before the radical operation can prevent single cancer cells from metastasis via portal vein.

Adult↗
PubMed1999

[One stage surgical repair for complex cranio-orbital injury].

OBJECTIVE: To approach clinical effect of early stage surgery on complex cranio-orbital injury. METHODS: Surgical procedures included removal of intracranial hematoma, contused and necrotic brain tissues, correction of cranio-orbital deformity, and repair of dure mater. RESULTS: Early evaluation was completed in 6 weeks, and late evaluation was made in 6 months after surgery according to the scale of Jennett and Bond's plastic surgical outcome and Glasgow outcome scale (GOS). Six weeks after surgery, GOS grade I was observed in 6 patients and GOS grade II in 3 patients. Excellent scale of Jennett and Bond was seen in 4 patients and good scale in 3 patients. Cerebrospinal leakage was effectively obstructed in 5 patients. CONCLUSIONS: Early stage repair for complex cranio-orbital injury may be conducive to improving neural function and decreasing intracranial infection.

Adult↗
PubMed1999

[The expression of MTS1 gene product in transitional mucosa adjacent to rectal carcinomas and its clinical significance].

OBJECTIVE: To study the property of transitional mucosa (TM) adjacent to rectal carcinoma and the clinical significance of MTS1 gene deficit. METHODS: We used the immunohistochemical methods to observe the range of TM adjacent to rectal carcinoma, and the immunohistochemical method to observe the expression of MTS1 gene product on TM, using normal mucosa and carcinoma tissue as control. RESULTS: The positive expression level of MTS1 gene product was the highest in the normal rectal mucosa, gradually defective in TM and carcinoma tissue (P < 0.05). The range of TM with MTS1 negative cases was prominently larger than that with MTS1 positive cases (P < 0.05). CONCLUSIONS: The inactivation of MTS1 gene is relative to the occurrence of rectal carcinoma, suggesting that the TM adjacent to rectal carcinoma possess as certain potential malignancy. TM is related to MTS1 gene expression deficit of rectal carcinoma, showing that MTS1 gene expression deficit or mutation may be a factor inducing transitional change adjacent to carcinoma.

Adult↗
PubMed1999

[Orbito-zygomatic approach for removal of tumors of the skull base].

OBJECTIVE: To evaluate the advantages and indications of orbito-zygomatic approach for removal of tumors of the skull base. METHODS: Fifteen patients with tumors of the skull base were operated on using obito-zygomatic approach. The advantages and indications of the approach were evaluated. RESULTS: In 7 cases of meningioma, total removal of the tumor was achieved in 6 cases, and subtotal removal in 1. In 4 cases of craniopharyngioma, the tumor were totally removed in 3 cases, and subtotally removed in 1. The tumor were totally removed in 2 cases of trigerminal neurilemoma and 1 case of germinoma. There was one operative death. All patients recovered except 3 who had minor extraocular parasis. CONCLUSIONS: This approach ensures additional space, and less cerebral retraction for easy access to skull base tumor, especially the large neoplasm of middle cranial base with or without orbital or posterior cranial base extension.

Adolescent↗
PubMed1999

[Phacoemulsification through a small pupil].

OBJECTIVE: To discuss the surgical techniques and attention points in phacoemulsification through a small pupil. METHOD: Eighty three cataracts of 77 patients were emulsified by using non-cut pupil dilation, cystotome or diathermic high-frequency capsulorrhexis. RESULTS: The 66 cataracts of 83 eyes were emulsified by means of the above method. After the surgery, all the pupils were recovered to normal size (2 to 3 mm), and none of them were damaged. In 17 eyes, the procedure was performed after separation of synechia and excision of the organized membranes; after the surgery, a round pupil was obtained in 15 cases and an irregular pupil in 2 cases. The visual acuity at postoperative 1 month was >or= 0.5 in 46 eyes (55.4%) and corrected >or= 0.5 in 71 eyes (85.5%). CONCLUSION: After phacoemulsification through a small pupil by non-cut pupil dilation method, the pupil can be recovered to normal and no unfavorable reaction is seen.

Adult↗
PubMed1999

[Vitrectomy for vitreous hemorrhage caused by retinal vein occlusion].

OBJECTIVE: To evaluate the efficacy and complications of vitrectomy for vitreous hemorrhage after retinal vein occlusion. METHODS: We retrospectively studied 47 patients (47 eyes) having undergone vitrectomy during the period from April, 1992 to December, 1996. Follow-up was made on 30 patients. RESULTS: (1) Visual acuity was improved postoperatively in 80% of the eyes. The patients with branch vein occlusion achieved more favorable final vision than those with central retinal vein occlusion (P < 0.05). (2) The most common complications were lens opacity, recurrent vitreous hemorrhage, iatrogenic rhegmatogenous retinal detachment and glaucoma. (3) Patients treated with endophotocoagulation had a lower rate of recurrent vitreous hemorrhage (P < 0.05). CONCLUSIONS: (1) More than half of the patients can achieve ambulant vision after vitrectomy for vitrous hemorrhage induced by retinal vein occlusion. (2) Recurrent vitreous hemorrhage can be effectively prevented by endophotocoagulation during the operation.

Adult↗
PubMed1999

[Surgical management of acute retinal necrosis].

OBJECTIVE: To investigate the effects of vitreoretinal surgery in the management of acute retinal necrosis (ARN). METHODS: 17 cases (20 eyes) of ARN had undertaken the surgery, including vitreoretinal surgery for 18 eyes and scleral surgery for 2 eyes. 14 cases (21 eyes) of ARN patients hospitalized at the same period without surgery were used as controls. RESULTS: The follow-up was 5 months to 5 years. 15 eyes in the control group (71.4%) became phthisis bulbi. Useful vision remained in 17 eyes in the surgical group. CONCLUSIONS: Retinal detachment is still a severe complication of ARN, and proper vitreoretinal surgery can improve its prognosis.

Adult↗
PubMed1999

[Measurement of retinal nerve fiber layer thickness of normal eyes with nerve fiber analyzer].

OBJECTIVE: To study the retinal nerve fiber layer thickness (RNFLT) of normal eye and the correlation with age. METHODS: RNFLT of 198 cases of normal eyes were examined by using nerve fiber analyzer (NFA). RESULTS: There were significant inverse linear correlation between the RNFLT and age (r = -0.46, P < 0.01). In the analysis by the quadrant, the RNFLT was correlated with age in the superior and inferior quadrant. The mean ratio of superior and inferior quadrant thickness (S/I) was 1.041. CONCLUSION: NFA seems to be an useful tool to measure the RNFLT quantitatively. The RNFLT of normal eye is found to be decreased with age.

Adolescent↗
PubMed1999

[A study on transplantation of rat photoreceptor cell layer].

OBJECTIVE: To study the relationship between photoreceptors and other layers of the retina in the aspects of anatomical structure, physiology, pathology, etc. METHODS: RCS rats were used as host animals, and the pure cone and rod layer of the donor retina was prepared from Wistar rat and was transplanted under the host retina where the cones and rods were degenerated. RESULTS: After 2 weeks of transplantation, the retinas of the host rats were reattached, and the transplanted cells were survival. The transplanted cells were in the subretinal space between the retinal pigment epithelium (RPE) and the inner unclear layer, and they had the staining characteristics similar to that of the normal control photoreceptors. CONCLUSION: In the animal model of photoreceptor cell layer transplantation, the transplanted cells possess normal anatomical location and are connected with RPE and inner nuclear layer. The results provide a new route to investigate the re-establishment of anatomical association with the optic nerve and the physiological activity of the nerve.

Animals↗
PubMed1999

[Changes of TF and TFPI activities in patients with hypertension or coronary atherosclerotic heart disease].

OBJECT: To investigate the changes of tissue factor (TF) and tissue factor pathway inhibitor(TFPI) activities in patients with hypertension or coronary atherosclerotic heart (CAH) disease. METHODS: TF activity was measured by two-stage assay, and TFPI activity was detected according to Sandset's method. RESULTS: Plasma TF activity in both patients with hypertension and patients with CAH disease was higher than that of normal control(P < 0.05). CONCLUSION: Hypercoagulative state may be involved in the pathogenetic processes of hypertension and CAH diseases. TF and TFPI activities have the likelihood to become the accessory diagnostic indexes for hypertension and CAH diseases.

Adult↗
PubMed1999

[Partial splenic embolotherapy in hypersplenism with portal hypertension].

Twenty-one cases of hypersplenism with portal hypertension were treated with partial splenic embolization. The results were that spleens were shrink and the condition of white blood cells, platelets, and prothrombin time of the patients were obviously improved. We conclude that the appropriate antibiotics, superselective catheterization, and the management of postoperation are necessary; the volume of embolism is limited from 50% to 75% of the spleen. This technique has the features of steady therapeutic effect, safety, and microtrauma.

Embolization, Therapeutic↗
PubMed1999

[Expression of vascular endothelial growth factor in brain astrocytoma and its clinical evaluation].

Angiogenesis is often involved in tumor growth. Neovascularization plays an important role in the prognosis of patients with brain astrocytoma. Vascular endothelial growth factor (VEGF) has been known as the potent angiogenetic factor and mitogen. To gain a deep insight into the possible relation between expression of VEGF and pathological characterization/prognosis in brain astrocytoma, the authors investigated 107 cases of brain astrocytoma and 25 cases of normal brain, tissue via a combination of immunohistochemical staining of paraffin-embedded tissue and follow-up survey. The results showed that the positive staining rate and PU (positive unit) were obviously higher in astrocytoma than that in normal brain (86.92% vs 16.00%, P < 0.05), that the value of the positive staining rate and PU in astrocytoma corresponded closely with its pathological grade and stage (P < 0.01), and that the survival rates (6, 12, 24 months) for the patients suffering from astrocytoma gradually decreased when the VEGF positive rate increased. These suggest that the expression of VEGF may have close relationship with brain astrocytoma and the measurement of the VEGF expression may provide another potential standard for judgement about pathological grade/stage and clinical prognosis in brain astrocytoma.

Adult↗
PubMed1999

[The key enzyme of cholesterol synthesis pathway: HMG-CoA reductase and disease].

In eukaryotes, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase is a key enzyme that catalyses the synthesis of a precusor of cholesterol as well as non-sterol isoprenoids, mevalonate. The regulation of the enzyme activity occurs at the transcription, post-transcription, translation and protein degradation levels. Cholesterol contributes to the generation and development of atherosclerosis while non-sterol isoprenoids play a role in regulation of cell proliferation, signal transduction and generation of cancers. At present, the enzyme is the target of several drugs effective against atherosclerosis.

Cholesterol↗