Morphology of experimentally induced so-called keratoacanthomas and squamous cell carcinomas in 2 inbred-lines of Mastomys natalensis.
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Biomedical subjects
Publications and source records attributed to W Thiel.
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With both light-microscopy and electron-microscopy, glomerular lipidosis in the dog appears in two forms which can freely pass into each other: 1. A nodular non-compressing form, and 2. and expansive compressing form. The focal areas are completely surrounded by a basal membrane. The covering podocytes are basically unchanged. The primary site of lipid deposition is the mesangial cell, not the endothelial cell.
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In the course of a study which was made in order to contribute to the knowledge about influenza viruses in birds, 18 strains of avian Influenza-A-subtypes were isolated from cloaca swabs. From the Central European bird species, one strain of Influenza A/England/62 was isolated from a mallard. All other species of birds obtained from three different biotopes from Austria and Hungary showed negative results. The other 17 influenza strains were isolated from imported birds from Senegal. Nine of these strains corresponded to subtype A/duck/England/62, five to subtype duck/England/56. One isolated strain showed a relation to A/duck/England/56 in terms of the hemagglutinin and to chicken/Brescia/1902 in terms of the neuraminidase. Two other strains reacted best with antisera against duck/England/62 in the hemagglutination inhibition test; the neuraminidase inhibition test showed a relation to subtype quail/Italy/65. The Newcastle disease-Virus was not isolated in any sample.
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In skin neoplasms (so-called keratoakanthomas, papillomas, and squamous cell carcinomas) of Mastomys natalensis (GRA Giessen) virus particles and viral antigens were demonstrated in distinct epithelial layers. Nuclei of the upper parts of the stratum granulosum and disintegrated cell parts of the stratum corneum contain viral structures. The localization of virus particles and viral antigens in any skin neoplasms of M. natalensis (GRA Giessen) corresponded to the sites where papillomavirus-specific material had been demonstrated in papillomas of other species.
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In the years from 1954 to 74 sensitivity tests with about 12 000 strains of tubercle bacilli isolated from patients have been performed by the serial dilution method. From the results of the tests shown in the table one can see a remarkable shift in the frequency of strains sensitive against the so-called major drugs Streptomycin and INH, whereas only slight variations have occurred with the recent drugs Ethambutol and Rifampicin. The well known change of clinic and epidemiology of tuberculosis in the past two decades is indeed accompanied by changed results of microbiological tests. In conclusion the present chemotherapeutical situation proves much better than in 1954: to-day a more sensitive and even smaller reservoir of mycobacterium tuberculosis is facing twice as much highly effective drugs than formerly.
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