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Biomedical subjects

W Thiel

Publications and source records attributed to W Thiel.

At least 73 records · Page 4Linked to original sources
PubMed1985

[Resistance of blood culture isolates in vitro to 4 aminoglycoside antibiotics in Austria--1982/83].

Over the period September 1982 to February 1983 268 blood culture isolates were consecutively collected in 4 microbiological laboratories in Austria (Linz, Vienna, Graz, Feldkirch) and 251 of these strains (streptococci excluded) were tested for resistance to Gentamicin (G), Tobramycin (T), Netilmicin (N) and Amikacin (A) using a microtitre broth dilution method. This investigation was part of an international study. Of the bacterial strains examined 57% were staphylococci (34% Staphylococcus aureus) and 43% gram-negative rods (18% E. coli, 17% other enterobacteriaceae and 5% Pseudomonas aeruginosa etc.). 25% of all strains tested were resistant to Gentamicin (MIC greater than 4 mg/l), 27% to Tobramycin (MIC greater than 4 mg/l), 6% to Netilmicin (MIC greater than 4 mg/ml) and 5% to Amikacin (MIC greater than 8 mg/l). The resistance rate of staphylococci was markedly greater towards Gentamicin (35%) and Tobramycin (39%) than Netilmicin (4%) and Amikacin (6%). The respective percentages of resistant gram-negative rods were considerably smaller, except in the case of Netilmicin (G 13%, T 11%, N 8%, A 4%). Regional differences were observed between Linz and Vienna in the resistance of staphylococci to Gentamicin (24% versus 49%) and Tobramycin (33% versus 53%). On a weight basis Netilmicin was the most active substance in combating nearly all groups of bacteria. Also in strains sensitive to the other aminoglycosides the MIC values of Netilmicin were considerably lower than for the other substances. A noteworthy feature in comparison with the results of other countries participating in this international study was the distinctly higher incidence of staphylococci among the blood culture isolates and the considerably higher percentage of aminoglycoside-resistant strains in Austria. Analysis of the data suggests that the high resistance rates among staphylococci are a consequence of selection by frequently used antibiotics. Hence, it appears essential to observe the development of aminoglycoside resistance in Austria closely and to recommend that these substances, of extreme value in the treatment of severe infections, should be used solely for the most stringent indications.

Aminoglycosides↗
PubMed1984

[Fine structure and development of Sarcocystis aucheniae in llamas].

Isolated cysts of Sarcocystis aucheniae of the llama (Lama glama) were fed to one dog and one cat. Only the dog excreted sporocysts, measuring 13.1-15.7 (15.0 +/- 0.54) X 9.0-11.3 (10.4 +/- 0.36) micron after 11 days for 21 days. A second cat, which had ingested meat of a llama containing macrocysts of S. aucheniae as well as sarcosporidial cysts visible only under a microscope also did not excrete sporocysts. The cysts of S. aucheniae are surrounded by a folded primary cyst wall forming cauliflower-like protrusions into the muscle fibre. The protrusions contain numerous microfilaments. In addition, the primary cyst wall forms numerous tiny vesicles. The parasitized muscle fibre is located in a large cavity within the normal muscle tissue. The cyst wall of S. aucheniae is similarly structured to that of S. gigantea of the sheep.

Animals↗
PubMed1984

[Epidemiology and phage typing of Salmonella typhimurium in Austria 1980-1982].

From 1980 to 1982 a total of 4541 strains of S. typhimurium of human origin and 745 S. typhimurium of non-human sources were received by the Salmonella Centre. During this period, the percentage of S. typhimurium rose from 33% to 51% (human origin) and from 12% to 33% (non-human origin), respectively. The incidence of infection was 20.0, the regional distribution showed a prominence of the eastern and western parts of Austria with Styria as leading country (46.2). 60% of the isolates of S. typhimurium were associated with illness, which was 10% more than for the other salmonellae; concerning outbreaks as well as single cases, S. typhimurium dominated, whereas the proportion of carriers of S. typhimurium among foodhandlers was small (12% S. typhimurium, 31% other salmonellae). As to the age-specific attack-rate, children younger than 5 years by far predominated with 67.2, with a falling tendency in the other age groups. As far as food is concerned, the increase of S. typhimurium in poultry is particularly striking. According to the phage-typing results, LT 10 was prominent in the years 1980 and 1981, whereas in 1982, LT 66, accounting for 62% out of 2201 tested human isolates dominated among 44 different phage-types as epidemic strain, especially in Styria and eastern Austria. In addition, LT 10 and LT 3 could be found more frequently. Starting from the important role of food in Salmonella associated enteritis, LT 66 leads to chicken as the main source of infection. Apart from LT 66, LT 1, 2, 3 and LT 140 were more frequent in non-human isolates. This infiltration of LT 66 into the Austrian chicken industry could have its origin in imported parent chickens. As mechanism the single replacement of LT 10 by LT 66 is discussed as well as the phage-conversion of LT 10. The other possible chains of infection (other poultry, feeding-staff, man) are regarded as less probable. To prove this thesis investigations on plasmids should be done.

Austria↗
PubMed1983

[Prolactin and male fertility].

On 68 selected patients with disturbances of the potentia generandi et/sive coeundi (25 males with healthy metabolism and 43 males with diabetes) as well as 14 control persons PRL, LH, FSH, testosterone and oestradiol were determined radioimmunologically and the results were ascribed to sexological, clinical, spermatological and testo-histological findings. A statistically secure correlation was found between PRL values and disturbance of the libido as well as the presence of a gynaecomasty. PRL did not correlate with the spermatological variables volume of ejaculate, relative and absolute number of spermatozoa and motility. PRL did also not correlate with the testohistological findings. A relation between PRL and the peptide hormones LH and FSH as well as the steroid hormones testosterone and oestradiol could not be ascertained. Therefore the diagnostic values of a PRL determination is much limited; the pertinency of a hyperprolactinaemia may be increased by the proof of the symptoms reduction of libido and gynaecomasty with simultaneous disturbance of fertility. In our opinion the definition of hyperprolactinaemia needs revision, since at only determination of the basal value of more than 800 mU/l no more frequently pathologically andrological findings are to be observed than below 200 mU/l.

Adult↗
PubMed1983

[Fertility prognosis of the male].

In 1977/78 5418 childless human males were examined andrologically and followed up 24-36 months later. Depending upon these results a partial correction of the evaluation criteria of spermatological findings is necessary. The normal values of sperm density and motility rate are obviously lower than hitherto reported in the international nomenclature. Fructose concentration in seminal plasma does not allow to make reliable statements on the prognosis of fertility.

Ejaculation↗
PubMed1983

[Relations between sperm findings and fertility prognosis in childless couples].

In eight andrological centres more than 2,000 childless married men were examined catamnestically. Fertility was compared with the findings of the routine spermatograms. Conception rate is reduced significantly if sperm density is below 10 million, in motility of spermatozoa under 50% and in ejaculates with less than 60% normal-shaped spermatozoa. However, lower values of spermatozoa must not be compared with absolute infertility.

Humans↗
PubMed1982

[Clinical studies of intra-articular injections of Arteparon. Retrospective study following the treatment of 754 patients].

Glycosaminoglycan polysulfate (GAGPS = Arteparon) is used for the treatment of degenerative joint diseases; it inhibits enzymes that dissociate ground substance, e.g. hyaluronidase, beta-glucuronidase, and acid phosphatase. In turn, an improved synthesis of hyaluronate from the synovial lining cells to hyaluronic acid increases viscosity (Verbruggen and Veys 1977). From January 1975 to December 1979, in the Orthopedic Division of the Clinic "St. Elizabeth" in Saarlouis, West-Germany, we treated 754 patients with a total of approximately 8000 intra-articular injections of Arteparon. The problem with drugs influencing the metabolism of joint cartilage is that the results cannot - for obvious reasons - be as conspicuous as e.g. with corticoid injections, although the latter sometimes involve also marked side-effects. After several courses of therapy, on the other hand, the cartilage-protective effect of Arteparon becomes apparent, with an effect lasting for several months. The indications to include the patients into our study were: arthrosis and other cartilage disorders that had been diagnosed prior to onset of therapy by means of either X-ray, surgery, arthrography etc. Therapeutic results were measured by the parameters: subsidence of pain, recession of edema, improved joint motion, etc. Arteparon, applied intra-articularly, was well tolerated; local irritation, and swelling of the treated joints were reported in only 4.7% of the treated cases; the therapeutic overall result was good. Occasionally, a case of headache was observed, however, no case of joint infection was reported.

Adolescent↗
PubMed1982

[Evidence of Salmonellae in the Mur river; comparison 1969-1981].

In summary, we would like to emphasize that the significance of modern waste water purification plants is generally recognized today. However, salmonella concentration in the water of the Mur river has not decreased, in spite of increased numbers of waste water purification plants and related measures taken in the past decade. This statement is not a criticism, but a deplorable fact which must be acknowledged by all who are involved in the combat against salmonellas.

Austria↗
PubMed1981

[Testicular biopsies in male diabetics].

Histological exazerbations in 17 diabetics who underwent a biopsy of the testicles and 6 control persons with healthy metabolism could increasedly prove findings deviating from the normal in male diabetics. Disturbances of the germinal epithelium of slight to middle degree are in the foreground, which must not be overvaluated in their effect on fertility. In the relatively frequent childlessness in the marriages of diabetic males disturbances of the potentia coeundi apparently play an important role.

Adult↗