[The 65th birthday of Professor Hans Petzold].
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Biomedical subjects
Publications and source records attributed to W Teichmann.
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Immunological tests were performed in 34 patients undergoing hydrotherapy according to Kneipp. IgM, alpha2-macroglobulin and complement factor C3 concentrations were increased after this treatment, but not in ten healthy volunteers. Specific antibody activities (staphylococci, E. coli, streptococci) remained unchanged. After intracutaneous testing with different protein and bacterial antigens reactions were significantly more intense (diameter of reaction) after hydrotherapy, while total number of reacting patients remained the same. Pokeweed stimulation ratio was increased in the lymphocyte transformation test, while PHA and PPD stimulation rates remained unaltered.
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The use of cristalline fluids allows to gauge the changes of the superficial temperature by changing of the colour and to make them reproducible and visible. In a survey it is described as a new method of the measurement of the temperature of the skin.
It is reported on a group of 31 patients with pacemakers who were exposed to an orthostasis load without additional therapy as well as after an administration of nitrangin, euphyllin, rocornal and ergocomb. The lacking regulation of frequency in these patients can only limitedly be compensated by a volume regulation. Thus the simple standing experiment is already a considerable stress for these patients. Single applications of nitrangin and ergocomb led to an additional orthostatic decrease of blood pressure. This is particularly characterized after application of nitragin and also accompanied by subjective appearances up to the collapse. In the not doubted necessity to treat patients with pacemakers also conserning the coronary blood supply it seems important to take into consideration an additional iatrogenic disturbance of the orthostatic regulation.
In a retrospective study by means of a half-standardized method of interview in 154 patients with acute myocardial infarction and in a control group of the same age (n = 100) anamnestic data were established, particularly taking into consideration the preinfarction phase. 27% of the patients were surprised by an acute myocardial infarction without prodromal symptoms, in 32% the first occurrence of complaints of angina pectoris was during the last two months before the infarction. 41% had a preexisting angina pectoris which usually showed a crescendo-course with increasing approximation to the infarction. More than half of the patients reported on physical activity or/and emotional stress as causal factors of the preinfarction complaints. The correlation with the localisation of the infarction showed above all an occurrence of the prodromal symptoms in infarctions of the anterior wall and in lesions of the myocardium which in most cases could be ascertained only enzymatically. A greater accumulation of the prodromi was furthermore found in younger patients, in hypertension and preexisting restriction of the heart function. 70% of the patients with warning symptoms consulted a physician because of their heart complaints. In the control group 22% of the persons reported on heart complaints.
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After a short survey on the history of the therapy of liver cirrhosis the importance of the prevention of alcoholism is emphasized. A "liver diet" is regarded as unnecessary, prednisolone is recommended for the treatment of the active cirrhosis. After a short description of the principles of the therapy of biliary cirrhoses, of haemochromatosis and of Wilson's hepatocerebral degeneration the use of restriction of salt, saluretics and aldosterone antagonists in the treatment of ascites is discussed in detail. After description of the conservative therapy of the haemorrhage from varices with the compression sound, intraarterial octapressin infusion and combat against consumption coagulopathy finally the prophylaxis of the hepatoportal encephalopathy with reduction of the protein intake and the restriction of the formation of toxic products of protein metabolism in the intestine by application of neomycin or lactulose, respectively, is described.
The plethysmanometer described follows the principle of the relaxed wall of the vessel. Here the pressure is adjusted in a finger cuff and by means of a pneumatic regulation is varied in such a way that the light plethysmogram of the adequate finger does not show any more pulsations. Thus the pressure effected on the finger above the cuff corresponds to the pressure in the finger arteries and is to be registered in mm Hg. When the course is measured in the same test person with changing of the arterial pressure (e.g. absolute arrhythmia or compressed-air pressure experiment) the blood pressure of the aorta measured when a heart catheter is diagnostically indicated shows a very close correlation to the unbloodily registered pressure of the finger arteries. On the other hand, greater varieties of the correlation coefficient which can be proved from test person to test person at present do not yet allow a formula obligatory in general, in order to tansfer the value unbloodily measured into the adequate bloody one. Nevertheless, already nowadays great ranges of application are possible for the progressing measuring of the blood pressure.
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During 6 months lidoflazine was applied ambulatorily in a dosage of 240 mg/a day orally in 21 patients after finished infarction. After 2 to 3 weeks one patient each was excluded due to incompatibility or reinfarction, respectively. In the remaining 19 patients consumption of nitrangin, mechanocardiogram, ECG and blood pressure were controlled in regular intervals during and after ergometric load as well as clinico-chemical examinations performed. The consumption of nitrangin clearly decreased in the course of the time of observation. The tolerance ofthe medicament was good. At the end of the treatment the unchanging load was tolerated with lower pulse rate, slightly decreased blood pressure and shortened period of isometric contraciton and period of the increase of blood pressure. The present results were discussed compared with literature.
During cholecystectomy a catheter was inserted into the V. porta via V. umbilicalis. 7 or 8 days later an oral glucose tolerance test was performed (100 g). Blood glucose, insulin (IRI), proinsulin-like material (PLM), and pancreatic glucagon (IRG) concentrations were determined in portal as well as in peripheral venous blood. 5 out of 6 patients showed a disturbed carbohydrate tolerance in comparison to 53 healthy subjects. The IRI increased promptly after the oral glucose load. The portal IRI-concentrations are significantly enhanced in comparison to the peripheral levels, but between both a positive correlation exists (r = 0.9447; p less than 0.01). PLM was slightly increased in the first 10 minutes. The basal IRG levels were not enhanced. Significant differences between the portal and peripheral IRG concentrations could not be observed. The correlation coefficient was 0.8902. Thus, the peripheral venous concentrations of IRI, PLM and IRG can be used as a diagnostic tool of pancreatic hormone secretion in man.
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