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Biomedical subjects

W T Cooke

Publications and source records attributed to W T Cooke.

At least 127 records · Page 7Linked to original sources
PubMed1970

Pregnancy and Crohn's disease.

Of 77 married women with Crohn's disease, 25 were sterile. In the remaining 52 (98 pregnancies) the risks of prematurity, stillbirth, abortion, or congenital abnormality were not increased. There was no evidence that pregnancy exerted adverse effects on the course of the disease or increased the mortality rate. Sterility was the main problem encountered.

Abortion, Spontaneous↗
PubMed1970

Corticosteroid or corticotrophin therapy in Crohn's disease (regional enteritis).

Amongst 300 patients with Crohn's disease followed between 1944 and 1968, corticosteroids or corticotrophin was given to 124 patients, to 87 of them for more than 12 months. In the short-term assessment of 89 of these patients, 76% improved clinically within six months, but within 12 months 29% of these had relapsed. In the long term, the risk of operation each year for the patients treated with steroids was twice that of those not treated. There was a significantly increased mortality rate in the patients treated with steroids which in part was due to complications induced by this therapy for which no evidence of long-term benefit emerged from this study.

Administration, Oral↗
PubMed1970

Crohn's disease of the stomach and duodenum.

Clinical and radiological abnormalities in 12 patients with gastroduodenal involvement were encountered amongst 300 patients followed by one of us between 1944 and 1969. Symptoms of dyspepsia were relatively mild and obstructive symptoms when present were readily relieved by bypass surgery. The patients have been followed for a mean of 9.7 years (range 1-20); two have died of other causes but the remaining 10 are well.

Adolescent↗
PubMed1970

Peptic ulceration in Crohn's disease (reional enteritis).

The incidence of peptic ulceration in a personal series of 300 patients with Crohn's disease was 8%. Resection of 60 or more centimetres of the small intestine was associated with significantly increased acid output, both basally and following pentagastrin stimulation. Only five (4%) of the 124 patients who received steroid steroid therapy developed peptic ulceration. It is suggested that resection of the distal small bowel may be a factor in the probable increase of peptic ulceration in Crohn's disease.

Adolescent↗
PubMed1970

Fibinolysis in colonic disease.

Fibrinolytic activity of colic venous and arterial blood has been studied at laparotomy in 18 patients with ulcerative colitis or Crohn's colitis and compared with that of 17 patients with colonic carcinoma or diverticulosis. Using the dilute blood clot lysis time technique, no difference was detected between the fibrinolytic activity in colic venous blood from the two groups. When the clinical complications of bleeding or thrombosis are compared with fibrinolytic activity the only important association is between a low peripheral venous fibrinolytic activity and the occurrence of postoperative thrombo-embolic complications.

Adult↗
PubMed1969

Neurological disease after partial gastrectomy.

Clinical and laboratory signs of neurological disease were found in 14 patients many years after partial gastrectomy. Vitamin B(12) deficiency occurred in most patients, but only those three who had signs of subacute combined degeneration of the cord and no osteomalacia responded well to treatment.

Adult↗