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Biomedical subjects

W Strecker

Publications and source records attributed to W Strecker.

At least 73 records · Page 4Linked to original sources
PubMed1993

[Intraoperative recording of intramedullary pressures with a microprobe].

The implantation of femoral prostheses and intramedullary nailing for fracture stabilisation are well-established techniques in traumatology. Nevertheless, the obvious biomechanical advantages of intramedullary splinting are partly offset by occasional disturbances of pulmonary circulation and function. These disorders of pulmonary function are apparently correlated with an operation-induced increase in intramedullary pressure. A simple, low-invasive and reliable system for the measurement of intramedullary pressure is presented. The heart of the system is a microtip probe that converts changes in pressure into electrical impulses, which are then filtered and amplified in the pressure measuring system (PMS).

Bone Marrow↗
PubMed1993

[Vacuum sealing as treatment of soft tissue damage in open fractures].

In 1992, 15 of 152 patients with open fractures were treated with vacuum sealing. Drainage tubes are inserted into polyvinyl foam, which is used to fill in the wound or tissue defect. Polyvinyl foam and adjacent skin are covered with a transparent polyurethane dressing which is impermeable to bacteria. The connection of the drainage tubes to a suction device, such as vacuum bottles, produces negative pressure in the polyvinyl foam, which means a high-contact zone of the foam-wound interface. This results in efficient cleaning and conditioning of the wound, with marked proliferation of granulation tissue. Bone infection did not occur in any of our 15 patients; 1 patient sustained a soft tissue infection due to an insufficient sealing technique. When the correct technique was applied the infection cleared up.

Adolescent↗
PubMed1993

[Endotoxin in blood plasma of patients after trauma].

Depending on the severity of the injury, high endotoxin levels may be found in patients with lung contusion but only slightly increased levels in patients with skull and brain trauma. This difference is highly significant. Patients with multiple injuries and fractures of the extremities as the main diagnosis and with a combination of injuries show a moderate increase in endoxin level on the day of admission. There is no relationship between the injury severity and endotoxemia.

Adolescent↗
PubMed1993

[Primary treatment of gunshot and explosion injuries of the extremities with the Ilisarov ring fixator].

High-energy missile and explosion injuries of the upper and lower extremities are complex and require treatment over a long time. Following classic strategies of surgical therapy, bone defects can be reconstructed only after the injured soft tissue has healed. The callus distraction technique now permits the beginning of bony reconstruction at the same time as the initial surgical debridement. During the period 1 July 1987 to 30 June 1990, 25 grade III open fractures in 24 patients were primarily treated with the Ilisarov technique at Wazir Akbar Khan Hospital, Kabul, Afghanistan. Twelve months after the removal of the fixation devices the patients were examined and the following results were demonstrated: no amputations; bony, aseptic healing in 22 cases (88%); 3 non-unions, including 2 infected non-unions; 2 axial deviations > 10 degrees. The primary initiation of bony reconstruction by callus distraction offers numerous advantages in the treatment of gunshot and explosion injuries.

Adult↗
PubMed1992

[Therapy of patients with multiple traumas: interdisciplinary organization at a specialized center].

By utilizing all its specialist facilities, the specialized trauma centre can optimize the chances of survival of the severely injured patient. However, this is possible only when the specialties involved have the ability to cooperate and when a "team leader" applying treatment guidelines worked out and accepted on an interdisciplinary basis is available to coordinate activities.

Humans↗
PubMed1992

[Computed tomographic torsion-angle and length measurement of the lower extremity. The methods, normal values and radiation load].

Complex corrective osteotomies in the lower extremities require precise preoperative planning. Fifty patients (37 male, 13 female) with an average age of 31 years (13 to 61 years) who had suffered fractures of the lower limbs and had been treated by osteosynthetic or conservative methods were studied, using a GE 9800 Quick CT; accurate and reproducible measurements of the angles of torsion of the femur and tibia were obtained. Digital images were produced to standardise the planes of measurement and to measure the length of the limb. The normal extremities of patients older than 18 years showed internal torsion of -20.4 +/- 9 degrees of the femur and external torsion of 33.1 +/- 8 degrees of the tibia. The most important clinical measurement is the intra-individual difference of the torsional angles. Amongst normals this is 4.3 +/- 2.3 degrees in the femur and 6.1 +/- 4.5 degrees in the tibia. Consequently, only angles greater than 9 degrees in the femur and 15 degrees in the tibia should be regarded as abnormal. Radiation exposure was measured by a LiF-thermoluminescence dosimeter on an Alderson phantom. Skin dose was 6.3 +/- 1.2 mGy and gonadal dose for females was 2.5 +/- 0.3 mGy and for males 0.7 +/- 0.1 mGy.

Adolescent↗
PubMed1992

[Surgical treatment of fractures in tropical countries].

In tropical countries, the indication for operative treatment of fractures treatment must be restrictive. Based on our own experience and the treatment results, the prerequisites for operative treatment are given and proposals concerning indication, preoperative preparation and operative tactics. The osteosyntheses recommended are the different forms of external fixation, in particular the external fixator (AO) and the transfixational plaster cast technique. The external fixator is the basic tool in tropical traumatology.

Adolescent↗
PubMed1991

The transfixational plaster cast technique.

Unstable fractures of the forearm and leg as well as combined fractures of the arm and forearm are often difficult to treat adequately by closed reduction and plaster fixation. In tropical countries, however, open reduction is relatively contra-indicated because of increased risk of peri-operative infection, inadequate training of medical personnel, and lack of adequate equipment. Given these conditions, the use of the transfixational plaster cast offers an alternative which is simple, inexpensive, and with few complications. The principle and technique of the transfixational plaster cast are presented.

Bone Wires↗
PubMed1991

Comparative evaluation and practical importance of instrument-free HIV-1 antibody screening assays.

Four instrument-free, visually read assays for detection of HIV-1 antibody were evaluated using 1,133 serum specimens from blood donors and patients in a rural hospital in Northern Zaire. Sensitivity for the four assays ranged from 85.9% to 95.0% and specificity ranged from 88.5% to 98.6%. Problems were caused by uninterpretable results in the range of 2.8% to 7.8%, decreasing somewhat the value of those systems. Based on our results, practicability and costs of the assays, we propose a hierarchy for testing for blood donors and for diagnosis of AIDS, adapted for hospitals in tropical countries.

Acquired Immunodeficiency Syndrome↗
PubMed1981

Ultrastructural changes in rat hepatocytes after partial hepatectomy, and comparison with biochemical results.

Ultrastructural changes in rat hepatocytes in the first 24 h following partial hepatectomy (p.h.), i.e. in the premitotic phase of liver regeneration, were studied using electron microscopic morphometry. Livers were investigated 1/2, 1, 4, 8, 12, 20 and 24 h after p.h. and 1/2, 8, 20 and 24 h after a sham operation. Two effects appear to be associated specifically with the regeneration process: (1) an increase in the volume density of lysosomes to a peak between 4 and 8 h after p.h.; and (2) a doubling in the number of mitochondria per cell by 24 h without any associated increase in the total mitochondrial volume. Two further changes were observed only after p.h.: (1) a massive accumulation of lipid in the form of lipid droplets by 24 h; and (2) the appearance of 'protein droplets' (very large lysosomal-like structures) at various stages. Both these changes appear to be secondary effects associated with the stimulation for, but not necessary to, cell division. The loss of glycogen observed immediately after both p.h. and a sham operation is a non-specific effect probably resulting from operation-induced stress. The results are discussed with reference to the changes observed in the biochemical composition of blood plasma. Glucagon appears to play an important role in the stimulation of some of the ultrastructural changes observed.

Animals↗
PubMed1980

Evidence for and characterization of a liver cell proliferation factor from blood plasma of partially hepatectomized rats.

A boiled extract acidified to pH 5.5 from the blood plasma of partially hepatectomized rats was treated with neuraminidase and injected i.p. into untreated rats. The DNA-synthesis of the liver cells showed a four-fold increase in comparison with controls. Extracts from the plasma of partially hepatectomized rats without neuraminidase treatment showed no increase in DNA-synthesis. Injections of boiled acid extracts from plasma of normal rats, however, showed no comparable differences before and after neuraminidase treatment. The activity of neuraminidase treated boiled, plasma extract is lost after treatment both with trypsin-chymotrypsin and with beta-galactosidase. Gel chrmoatography of the factor gave a molecular weight of about 38,000 D. The specific activity of the active extract after chromatography was raised by a factor of 300. According to affinity chromatography the factor was shown to be a glycoprotein containing N-Ac-glucosamine. The factor is inert with respect to the proliferation of spleen and kidney, i.e. it is organ specific. According to these results a regulatory system of hepatopoiesis is proposed.

Acetylglucosamine↗
PubMed1980

Metabolic changes in the serum of partially hepatectomized rats.

The factor(s) which trigger the proliferation of liver cells after partial hepatectomy in rats are not yet known with certainty. A series of specific and/or non-specific substances are said to effect the proliferation of liver cells, but metabolic changes after partial hepatectomy possibly also act as a contributory causative factor in the stimulation of those substances. In order to define this question more clearly the changes in the serum concentrations of the following metabolites in the course of time after partial hepatectomy were determined: free fatty acids, cholesterol, triglycerides, glucose, free amino acids and total protein. A reduction in the serum concentrations of some fatty acids and of glucose, and an increase in that of the free amino acids, was observed shortly after partial hepatectomy. The increase in the plasma concentration of immunoreactive glucagon after partial hepatectomy is thus explained and appears not to be of decisive significance for the stimulation of liver cell proliferation after partial hepatectomy.

Amino Acids↗
PubMed1980

Changes in hepatocyte volume and liver weight in rats in the early phase after partial hepatectomy.

The weight of the liver remaining at various times after 2/3 partial hepatectomy (p.h.) was determined as a percentage of its weight at the time of operation, calculated from the known weight and percentage of liver removed. The percentage change in liver weight was shown to correlate closely to the percentage change in average "mononuclear" hepatocyte cell volume as determined by light microscope morphometry. Average hepatocyte volume remains within 10% of the initial value for the first 14 h after p.h. therefore increasing to 130% of initial volume at 24 h after p.h. Average hepatocyte volume in sham operated animals is reduced to 68% of initial volume by 0.5 h after operation, returning to normal by 24 h after operation. A similar decrease was observed in the average hepatocyte volume of animals starved for 19 h.

Animals↗
PubMed1978

[Concentration and characterization of a liver cell proliferation factor from partially hepatectomized rat livers (author's transl)].

An extract of rat liver, made 12 h after partial hepatectomy, was injected into untreated rats. The synthesis of DNA in the liver cells of the injected animals showed a 3.3 fold increase in comparison with controls. A similar increase was observed in the mitosis index. Injection of liver extracts from normal rats showed no effect when compared with the injection of NaCl. The effect of the active extract was not altered by neuraminidase treatment. Trypsin-chymotrypsin treatment, howerver, removes the activity. The active factor must therefore be either a protein or a protein-like substance. The molecular weight of the factor was shown to be between about 30 000 and 50 000 by molecular filtration. The specific activity after molecular filtration was raised by a factor of 100. The factor is inert with respect to the proliferation of kidney and spleen. It is apparently not species-specific, however, since it also causes increased proliferation of liver cells in normal mice.

Animals↗