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Biomedical subjects

W Straube

Publications and source records attributed to W Straube.

At least 73 records · Page 4Linked to original sources
PubMed1987

[Detection of the early pregnancy factor (EPF) in the serum of patients with questionable pregnancy].

The early pregnancy factor (EPF) has been detected in sera of 24 women with a doubtful pregnancy by means of the rosette inhibition test using a horse antihuman lymphocyte serum. In all sera of women with an intact early pregnancy the EPF was found, furthermore in a pregnancy ending as abortion and two cases of an Arias Stella phenomenon. In non-pregnant patients the EPF was not detectable with exception of two patients under medication and one patient suffering from dysmenorrhea membranacea.

Chaperonin 10↗
PubMed1986

[Levels of tumor markers (orosomucoid, pregnancy-associated alpha 2-glycoprotein, pregnancy protein-1, placental specific-tissue protein 10, placental specific-tissue protein 12, alpha 1-fetoprotein) in the serum of patients with bronchial carcinoma].

Concentration of orosomucoid, pregnancy associated alpha 2-glycoprotein (alpha 2-PAG), Schwangerschaftsprotein 1 (SP1), placental specific-tissue protein 10 (PP10), placental specific-tissue protein 12 (PP12), alpha 1-Fetoprotein (AFP) were estimated in serum samples of 83 patients with lung cancer of stages II-IV. The proteins were determined by means of the single radial immunodiffusion, the rocket immunoelectrophoresis, the radioimmunoassay and the enzymeimmunoassay. Orosomucoid, PP12 and AFP serum concentrations of the cancer group compared with those of the control group, were increased significantly. Orosomucoid (control group: means = 0.828 g/l; s = 0.301; tumour group: mean = 2.16 g/l; s = 0.862); PP12 (control group: mean = 54.08 micrograms/l; s = 61.70; tumour group: mean = 122.52 micrograms/l; s = 131.16); AFP (control group: mean = 3.05 micrograms/l; s = 3.76; Tumour group: means = 8.29 micrograms/l; s = 17.75). alpha 2-PAG was found only in 37 cases of the tumour group; SP1 in 22 cases. PP10 (control group: mean = 2.25 micrograms/l; s = 0.866; tumour group: mean = 2.503 micrograms/l, s = 1.508). On condition that 2 tested parameters at least were estimated in the pathological range the sensitivity amounted to 0.64 and the specificity to 0.92.

Aged↗
PubMed1986

[Detection of circulating immune complexes in the serum of pregnant patients in normal pregnancy and in pregnancy-induced hypertension using precipitation by polyethylene glycol].

30 non-pregnant women, 250 women with normal pregnancy and 130 women with pregnancy induced hypertension (PIH) have been examined to show the presence of circulating immune complexes in serum. The immune complex concentration in normal pregnancy shows a rapid decrease from 6th up to 12th gestational week, then a plateau near to 35th week and further a slight increase. Decrease and increase can be described only with hypothesis. The immune complex concentration in 1st and 3rd trimenon of normal pregnancy was significantly different to non-pregnant women. As like as the group of normal pregnancies the women with PIH showed an increase of immune complex concentration on a higher level, but the differences between both groups were not significant.

Adolescent↗
PubMed1986

[Occurrence of antibodies against influenza viruses in the female genital tract of mice following oral immunization].

Antibodies of IgA-class against influenza viruses were detected by an enzyme immunoassay (ELISA) in uterus homogenates and uterus lavage fluids of NMRI-mice following immunization. Immunization was performed twice by the oral route within 14 days using a live influenza vaccine (A/PR/8/34, H1N1). Specific antibodies were estimated in homogenates as well as in lavage fluids. The results support the concept of a common immune mucosal system with local antibody secretion after remote-site stimulation in the intestinal tract.

Administration, Oral↗
PubMed1986

[New aspects in improved management of labor].

The increase of obstetric operating frequency observed in the last years is to attribute to a better recognition and valuation of maternal and fetal risk and on the other hand to a false interpretation of cardiotocography. With respect to induction and management of labour from a lot of partly controversial opinions is the following to conclude for the practice: Utilisation of all diagnostic possibilities including fetometry, pelvimetry, and cervical ripeness. Therapeutic arrangement should include cervical ripening, mobilisation of patient and labour timing depending on internal tocometry. The operative delivery is to consider as an ultima ratio. Labour management can be optimated by means of a clinic-specific partogram considering the active phase. Every indicated induction of labour demands internal tocometry. The pharmacological control of uterine activity must be used differentially. It must be waited for, if the quantification of labour activity improves the obstetrical-perinatological parameters.

Cesarean Section↗
PubMed1986

[Evaluation of cervix dilatation in the active phase].

This paper describes a prospective study of 50 primiparae and 50 multiparae, whose duration of cervical dilatation in the active phase has been investigated. The rate of cervical dilatation after 3 cm was found at 1.93 cm/h in primiparae and nearly one and a half times faster in multiparae. Friedman's S-shaped curve of cervical dilatation could not be confirmed.

Cervix Uteri↗
PubMed1986

[Immunology of the fetomaternal interaction: immunologic significance of colostrum and breast milk].

The importance of the mammary gland as a potential immunological organ is characterized in this literature survey by the following aspects: immunoglobulins in colostrum and mother's milk, immunological active cells in colostrum and mother's milk, nonspecific factors in the mother's milk. The importance of the early nursing is emphasized from the immunological point of view.

Antibody Formation↗
PubMed1985

[Clinical observations in vascular occlusion of kidney tumors by absolute alcohol].

The results of the occlusion of renal tumors by two different materials-Ethibloc (n = 26) and absolute alcohol (n = 72) are being compared. The kidneys were occluded under equal clinical conditions. The clinical symptoms following embolisation are fewer in the group of alcohol embolized patients than in the group with Ethibloc. On the capillary level, the histological reaction to alcohol corresponds to a histotoxic alteration. This reaction goes beyond the reactive inflammation of the tissue observed after Ethibloc. This intensified reaction of the tissue after alcohol application partially explains the advantage of a fractionated application of alcohol during tumor embolisation.

Angiography↗
PubMed1985

[Detection of secretory immunoglobulin A (S-IgA) and secretory component (SC) in cystic fluids from ovarian tumors and ovarian cysts].

Secretory immunoglobulin A (S-IgA) and secretory component (SC) were estimated by means of double radial immunodiffusion and single radial immunodiffusion in 22 cystic effusions from 22 patients with cystic ovarian tumours and ovarian cysts. For the quantitative estimations of S-IgA a S-IgA standard preparation was used. S-IgA and/or SC were demonstrable in all cases of the mucinous cystadenomas and also in the cystic effusions of an endometrioid adenocarcinoma and of a serous cystadenoma. The S-IgA values were estimated between 230 and 1330 mg/1. The estimation of S-IgA in cystic effusions is useful to support and extend the histological diagnosis of ovarian tumours.

Adenocarcinoma↗
PubMed1984

Electrophoretic mobilities and levels of T and B lymphocytes in human pregnancy.

Automatic cell electrophoresis has been used to investigate electrokinetic properties and the levels of T and B lymphocytes in peripheral blood of 124 pregnant women at different stages of gestation, and in 44 healthy controls. The electrophoretic mobilities (EPM) of T and B lymphocytes in maternal peripheral blood vary only slightly throughout pregnancy. In the pregnant subjects, there is a small but significant reduction in the percentage of circulating T lymphocytes. It is concluded that an increased electrostatic repulsion between maternal lymphocytes and trophoblast cells by alterations in the surface charge of lymphocytes plays an unimportant role in protecting the allogenic fetus from maternal immune attack.

B-Lymphocytes↗
PubMed1984

[Immunotherapy with immunoglobulins].

Based on the recent knowledge about synergism of antibiotics and immunoglobulin preparations the intravenous immunoglobulin application becomes significant with respect to prophylaxis and therapy of severe general infections. Immunoglobulins react specifically against surface structures of foreign bodies, inactivating in this manner small germs, viruses and toxins. Granulocytes and macrophages incorporate especially particles coated with immunoglobulins. A cumulative effect of antibiotics with respect to bactericidy could be observed in cases of an additional immunoglobulin application. Preparations available in presence are demonstrated. Those obtained by proteolysis or chemical blocking of the complement activating IgG-Fc-part are used on a large scale. Using the limitated sulfitolysis the application of an immunoglobulin was possible which was of internal structure. The so-called high dose immunoglobulin administration is to be preferred in prophylactical and therapeutical indications. In some cases fresh frozen plasma can be applicated for the purpose of immunosubstitution.

Anti-Bacterial Agents↗
PubMed1984

[Detection of pregnancy-specific beta 1-glycoproteins (SP1) and pregnancy-associated plasma protein A (PAPP-A) in maternal serum. Diagnostic significance in intrauterine fetal retardation].

The problem was to prove the value of SP1 (pregnancy specific beta 1-glycoprotein) and PAPP-A (pregnancy-associated plasmaprotein A) estimations in maternal serum samples for diagnosis of intrauterine growth retardation (IUGR). After delivery the pediatrician confirmed the diagnose of IUGR by means of clinical assessment. SP1 was estimated in 25 serum samples from 8 patients with IUGR and in 36 samples from healthy women by means of single radial immunodiffusion (24h-RID). Low SP1-values were found in serum samples from 4 patients with IUGR. There was a significant correlation (p less than 0,01) between SP1 concentrations and pregnancy weeks only in the control group. The regression line of the IUGR group was not different from 0 significantly. The estimations of PAPP-A were performed in 17 serum samples from 6 patients with IUGR. 24 serum samples from 12 healthy pregnant women were applied to control group. There was no difference between the 2 groups. PAPP-A is not suitable for diagnosis of IUGR.

Adult↗
PubMed1984

[Tumor markers (alpha 2-macroglobulin, secretory immunoglobulin A, pregnancy-associated alpha 2-glycoprotein) in the serum of patients with bronchial carcinoma].

Concentration of alpha 2-macroglobulin (AMG), pregnancy associated-alpha 2-glycoprotein (alpha 2-PAG, PZ) secretory immunoglobulin A (S-IgA), pregnancy specific-beta 1-glycoprotein (SP1) and immunoglobulin E (IgE) were estimated in serum samples of 88 patients with lung cancer of stages, II-IV. The proteins were determined by means of the single radial immunodiffusion and the rocket immunoelectrophoresis. AMG and S-IgA serum concentrations of the cancer group compared with those of the control group, were increased significantly. AMG (control group: means = 1,43 g/l; s = 0,999; tumor group: means = 4,37 g/l; s = 1,758); S-IgA (control group: means = 37 mg/l; s = 16,6; tumor group: means = 48 mg/l; s = 24,2). PZ was found only in 52% of the patients with lung cancer by means of the rocket immunoelectrophoresis. The difference between the tumour and the control group was not significant. IgE could be detected only in one case with lung cancer (IgE = 2950 IU/ml). It was not possible to detect SP1 by means of the single radial immunodiffusion in serum samples of lung cancer patients.

Adult↗
PubMed1984

[Detection of pregnancy specific beta 1-glycoproteins by means of laser nephelometry].

The pregnancy specific beta 1-glycoprotein in pregnant serum samples was detected by laser nephelometry. Protein estimations were carried out in 22 serum samples with laser nephelometry as well as 24 hour radial immunodiffusion test. The correlation of these methods was proved by a linear regression model and the correlation coefficient. It was ascertained a correlation coefficient r = 0,89 (p less than 0,01). The laser nephelometry is suitable for estimations of pregnancy specific beta 1-glycoprotein in pregnant serum samples.

Female↗
PubMed1984

[Determination of circulating immune complexes in the serum of patients with cytologically suspected and cytologically positive cervix smears].

In a pilot study there was taken away venous blood from 26 women for quantitative examination of circulating immune complexes because of cytologic suspected or positive diagnosis of the cervix uteri before planned conization. The concentration of immune complexes would be opposed to the colposcopic, cytologic and histologic diagnoses. In comparison to 26 women with cytological inconspicuous cervix diagnoses there is a light increase of immune complex concentration, but there is no significant difference between both groups.

Antigen-Antibody Complex↗
PubMed1984

[Substitution of immunoglobulins in severe infections].

In cases of severe infections substitution therapy of immunoglobulins shall improve the course of the disease. At example of a case report the possibility of the immunosubstitution is demonstrated. 31 days after the radical vulvectomy a bacteriantoxic phlegmone of the cutis and the subcutis in the abdominal, genital and thigh regions has been occurred. The acute medical care consists of shock therapy, large incisions of the cutis and the subcutis and high level antibiotic therapy. In the following course the immunoglobulins (Gamma-Venin) were substituted. The serum concentrations of IgG, M and A were estimated. The dosage of Gamma-Venin amounted to 1,5 grams per day. This dosage is lower compared with the amounts reported from other authors.

Aged↗
PubMed1984

[Absolute alcohol, an adjustable embolization material in kidney tumors].

Fourty-four patients with angiographically verified malignant renal tumors underwent a complete or selective embolisation of the affected kidney with absolute alcohol. The occlusion is effected by slow infusion of absolute alcohol. The technique is supported by animal experiments. The quantity of alcohol applied is measured by its intracorporal spread. The method of slow infusion is compared to other published embolisation techniques using absolute alcohol. This method allows an individual application of the vascular occlusion of the tumor supplying and the normal tissue supplying vessels, depending on size and localisation of the tumor, and further clinical data.

Angiography↗