Biomedical subjects
Publications and source records attributed to W Sixl.
Out of 1071 investigated patients had antibodies in 73.7% against Cytomegalovirus. 99 ambulant Kala-Azar-patients reacted positive in 33%. Inhabitants of different villages have shown 35.2 to 50% positive reactions. Patients with hepato-splenomegaly in 94% and patients with diarrhoea and fever in 81% were positive.
Investigations were carried out in Cairo's waste disposal sites of the inhabitants of all age groups. Germ-spectrum was analyzed before and after PVP-Iodine-treatment. However, any further dilution of PVP-Iodine in the treatment had no effect on the germspectrum, as hydrochloric acid formation in air, produced by plastic burning causes severe eye irritation and a constant lacrimation. The high germ count of the air in the dwellings and the environment is an additional source of contamination to the conjunctiva.
In Cairo's waste disposal sites various germs could be isolated from cockroaches and flies; antibiotic resistance was determined.
The authors examined 65 Rattus rattus, 28 pigs, 12 donkeys, 67 goats, 5 sheep, 1 cow and 1 dog as well as 196 inhabitants at two settlements on the waste disposal sites at the periphery of Cairo. Rattus norvegicus were positive in 55.4% for L. ictero-haemorrhagiae, pigs in 14.3% for L. pomona and in 3.6% for L. ictero-haemorrhagiae. 2 out of 12 donkeys were positive for L. pomona, 1 of them for L. pyrogenes and L. icterohaemorrhagiae as well, goats in 1.5% for L. grippotyphosa. Human sera reacted positively in 8.7% of the cases, 7.1% of which with L. bratislava, 1.0% with L. icterohaemorrhagiae and 0.5% with L. grippotyphosa and L. sejroe respectively.
In an epidemiological study of dogs carried out in Greece, antibodies against listeriosis were demonstrated in the slow-agglutination and the complement-fixation-reaction. Depending on the dogs' place of origin CFR titers were found in 6.1% to 51.1%. CFR-titers could be confirmed in a comparative investigation with the slow-agglutination-test.
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In Greece, not only raw meat feeding but also the possible faecal transmission of disease from the vast amount of strayed domestic cats play an important role in the incidence of toxoplasmosis among dogs. This must be concluded from the high contamination rate of 21.2% to 30.8% in all four presented investigations.
In serological investigations of dog sera from Greece for Q-fever 4.2% to 53.9% of samples were positive in the highly specific microagglutination test.
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According to our results the public fear in Greece of infection from dogs or the dog as a possible reservoir could not be confirmed. A total of 749 dogs were investigated. Positive findings were demonstrated successfully in 10 cases of 19 clinical cases and serologically confirmed in 10 cases. Strains were isolated in the experimental animal the hamster.
The authors examined serologically 353 clinically healthy persons in 5 localities in South Columbia for leptospirosis using the MAL-reaction with 15 serovars of 15 serogroups. The positivity was high - 18.4% namely with the serovars of the serogroups Icterohaemorrhagiae, Canicola, Pyrogenes, Australis, Pomona, Grippotyphosa, Sejroe, Hebdomadis, Bataviae, Panama and Shermani. Sera reacted positive in titer levels of 1:400 and higher only with the serovars of the serogroups Icterohaemorrhagiae, Canicola, Australis, Grippotyphosa, Sejroe, Hebdomadis, Panama and Shermani. In the total positivity were the serovars of the serogroups Icterohaemorrhagiae with 30.8%, Grippotyphosa with 23.1%, Australis with 15.4%, Panama and Pyrogenes with 10.8% each, Pomona with 6.2%, Shermani with 4.6% and Canicola, Sejroe, Hebdomadis, Bataviae with 3.1% each. The high positivity of the sera from the Mocoa for L.grippotyphosa was surprising - 20.7%.
The authors examined 984 human sera for leptospirosis with the serovars from 15 serogroups serologically in 15 localities of El Salvador. In 17.5% of the sera the following reactions were found with serovars of 13 serogroups: Australis 6.8%, Pomona 5.5%, Grippotyphosa 3.2%, Icterohaemorrhagiae and Tarassovi each 2.1%, Javanica, Canicola, Pyrogenes, Cynopteri, Autumnalis, Sejroe, Hebdomadis, Bataviae, Shermani, between 0.2%-1.4%. Men showed a 18.5% and women 17.0% positive reaction. Positivity increases with an increase in age, an increase was shown from 11.5% in the group of up to 10 years, to 40.4% in the group of 51 to 60 years, in the last age group of over 60 years a decrease was shown of 34.7%. In 8 localities we were able to compare the serological positivity of the population, the highest percentages were found in Fey Esperanza 35.1%, San Jose de la Montana 31.6% and Domus Maria 27.8%, the lowest in Credisa 6.4% and Ametepec 7.6%.
The probable correlations between certain Corynebacterium are discussed. Carpenter et al. (1976) describes a Corynebacterium equi-pneumonia in a patient with Hodgkin's disease; Gardner et. al. (1976) also reports on a case of pneumonia. Golub et. al. (1967) demonstrates a lung abscess resulting from Corynebacterium equi. Williams et. al. (1971) demonstrates a thoracic infection in an immunosuppressed patient. Although, our findings have been demonstrated only in conjunctivitis of children, hitherto descriptions of Corynebacterium equi in diseases of the lungs, especially in the case of a low immune response in certain sections of the population should be taken into account. Further investigations of the numerous dead donkeys with severe clinical symptoms of lung sequela are necessary.
Atmospheric germ measurements were carried out and the germ spectrum determined in medical ambulances, bedrooms and livingrooms.
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In the present paper the occurrence of different species of Pseudomonas, of Acinetobacter calcoaceticum var. anitratum and Aeromonas hydrophila in hospitals is described. The possible human pathogenic significance is discussed.
After testing various chemotherapeutics the following conclusions could be drawn: Pseudomonas was sensitive only to gentamicin. Gentamicin, aminopenicilline + calvulanacid and cefoxitin were 100% effective against E. coli. Gentamicin also proved effective against Enterobacter (83%). Cefoxitin, aminopenicillin + clavulanacid, gentamicin and trimethoprim + sulfonamide were effective against Klebsiella. Concerning Proteus sp., cefoxitin showed best results (100%). Acinetobacter was 100% inhibited by gentamicin. Gentamicin was most effective (93% sensitivity) against Staph. aureus. Trimethoprim + sulfonamide and erythromycine showed resistance rate of 17%, cefalosporine and isoxazolylpenicilline a rate of 21%. Aminopenicillin and aminopenicilline + calvulanacid were most suitable against Enterococcus (100%).
The authors subjected 611 human sera, 1295 sera of domestic and 211 sera of wild living animals from two islands of the Cape Verde archipelago to serological tests for leptospirosis. Among the human sera 7.2% reacted positively. Antibodies to L. bratislava of the serogroup Australis were most frequent (59.1% of all positive sera). Antibodies to L. icterohaemorrhagiae were found in 1.3% of the sera tested, to L. sejroe in 1.1%, to L. canicola in 0.7%, to L. pyrogenes in 0.3% and to L. pomona, L. bulgarica and L. grippotyphosa in 0.2% each. The existence of natural foci of leptospiroses could not be proved since tests of 211 wild-living mammals were all negative. The investigation of domestic animal sera showed a positivity of 3.1% with goats being positive most frequently (85% of all positive sera), followed by donkeys with 3.3% and cattle with 2.0%. Sera of dogs, sheep and pigs were all negative. The results indicate that anthropurgic foci exist on the Cape Verde Islands.