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Biomedical subjects

W Schmitz

Publications and source records attributed to W Schmitz.

At least 217 records · Page 12Linked to original sources
PubMed1982

Tissue glue for sealing plastic valves and bioprostheses in the canine aorta.

In experiments on seven dogs, a fibrin glue was used to seal plastic valves and bioprostheses in the thoracic aorta. Each valves was fixed in place with only four single sutures. Intraoperative and postoperative angiographic checks, with countercurrent aorta filling, gave no indication of perivalvular leak, even after eight weeks. Histologic studies confirmed the angiographic findings and showed only slight changes in the aortic wall. The results indicate that application of fibrin glue, supplementary to conventional suture procedure, may be useful when satisfactory fixation of aortic valves is hampered by pathologic circumstances.

Animals↗
PubMed1982

[The Haemonetics cell saver in open heart surgery (author's transl)].

A prospective study in 20 patients undergoing open heart surgery showed that up to 48 per cent of the required transfusion volume could be provided by autologous centrifuged blood. Re-transfusion of the washed packed red cells free of cell debris, heparin and aggregate significantly reduced blood loss both during and after the operation. The haemonetics cell saver is a valuable aid in the auto-transfusion technique.

Adult↗
PubMed1981

[Conclusive significance of gait analyses at the pelvis-leg skeleton (author's transl)].

Functional analyses of the gait of healthy male volunteers show approximately identical coordination of movement under standardised conditions. In contrast thereto, marked differences can be seen if the joint functions are disturbed and if there is an associated muscular insufficiency. These changes can be seen even in very minor joint affections in pain-free condition. The standardised course of the functions is suitable for describing characteristic changes in gait and to reveal some of the causal links. If these standardised conditions are employed, they offer the only possibility of assessing normalisation or progressive degeneration of pathological movement patterns.

Ankle Joint↗
PubMed1981

[Apico-aortic conduit for surgical treatment of supravalvular aortic stenosis with hypoplastic ascending aorta (author's transl)].

Surgical treatment of two patients with diffuse supravalvular aortic stenosis including hypoplastic aortic valve ring was undertaken. In both patients a left ventricular apical-thoracic aorta conduit containing a bioprosthesis was used. Intra- and postoperative pressure measurements demonstrated relief of the systolic pressure gradients present preoperatively between left ventricle and ascending aorta distal to the stenosis. Both patients are asymptomatic at four and eleven months after surgery, respectively.

Adult↗
PubMed1980

[Electrophysiological classification of newer antiarrhythmic drugs (author's transl)].

Newer antiarrhythmic drugs are tentatively classified on the basis of their influence on the transmembrane action potential, the fast sodium inward current and its kinetics, and the slow inward current which is primarily carried by calcium ions. Disopyramide is probably a quinidine-like antiarrhythmic drug, while the effects of aprindine, lorcainide, and tocainide resemble those of lidocaine. Mexiletine and propafenon cannot be classified definitely on the basis of the hitherto available electrophysiological data. Besides their effects on the fast inward current these substances may have additional calcium antagonistic properties.

Action Potentials↗
PubMed1980

[Clinical findings on heart myxoma (authors' translation)].

Clinical findings, diagnosis, and pathology of heart myxoma are discussed on the basis of personal experience with nine patients. There was a striking variety of signs and symptoms caused by tumor embolization, hemodynamic obstruction, and autoimmunologic reactions. Echocardiography is the method of choice, although angiography may still be necessary in atypical or negative echocardiographic findings. The tumor should be removed as soon as possible after diagnosis. There is danger of tumor embolization in the course of the operation. Long-term results are good, if resection of the tumors is performed before catastrophic complications occur. Morphologically, myxomas are genuine tumors characterized by myxomatous stromata and cells.

Adult↗
PubMed1980

[Clinical and experimental studies on pulsatile and continuous flow during extracorporeal circulation (author's transl)].

In 20 patients who underwent open-heart surgery, the plasma concentrations of glucose, insulin, glucagon, growth hormone, free hemoglobin, and cholinesterase were measured before, during and after pulsatile and continuous perfusion. Pulsatile flow was achieved by modification of a roller pump to effect rapid acceleration and slowing. The driving motor was interfaced with a control module to enable ECG-triggered perfusion. In addition to the clinical studies, investigations were performed in 9 dogs to assess the effects of pulsatile and continuous perfusion on liver and pancreas flow during total bypass. During pulsatile perfusion there was a significant increase in insulin which, however, was clearly diminished in relation to glucose levels. The response of the beta-cells was markedly more compromised after continuous than pulsatile perfusion. The secondary postoperative increase in insulin can be accounted for by intravenous administration of glucose and, particularly, after pulsatile perfusion, indicates an almost completely normal response of pancreatic beta-cells. As opposed to the effects of continuous perfusion, the low glucose, glucagon, and growth hormone levels, the insulin increase during and after pulsatile perfusion as well as normal cholinesterase values observed in association with pulsatile perfusion appear to be the result of improved pancreatic and hepatic function. This contention is supported by the experimental finding of significantly increased pancreas and liver perfusion during pulsatile perfusion.

Animals↗
PubMed1979

[Surgical management of traumatic thoracic aortic aneurysms using the TDMAC-heparin shunt].

Rupture of the aorta frequently occurs in major blunt trauma to the thorax, but few patients survive long enough to develop a chronic aneurysm. A TDMAC-heparin-coated shunt was used for operative procedures on the thoracic descending aorta in 5 patients aged 18--40 years. The lesions constituted in 4 recent ruptures and 1 chronic aneurysm. In 3 cases the aneurysm was resected and replaced with a prosthetic graft. End-to-end aorta sutures were performed in the other two cases. One patient died of renal and pulmonary insufficiency. There have been no complications attributable the shunt. The advantage of this shunt include elimination of the need for systemic heparin, avoidance of hypertension during crosslamping, and adequate perfusion of the distal circulation without an interposed pump. Because of the ease of handling and low risk we consider the use of this shunt the preferred method for operative procedures on the thoracic descending aorta.

Accidents, Traffic↗
PubMed1978

[Tryptophan metabolism and oligophrenia (author's transl)].

After dealing with the biochemistry of tryptophan metabolism the most important results obtained in humans are presented. Special emphasis is given to the hereditary defects of tryptophan metabolism associated with mental retardation and convulsions due to lack of pyridoxine. The author's findings demonstrate the existence of a hereditary disturbance of the tryptophan metabolism via kynurenine in a certain part of oligophrenic patients. This metabolic defect can be controlled by high doses of vitamin B6. Furthermore investigations conducted with a view to interpreting these results are discussed, especially the determination of kynureninase activity, serotonin blood levels and pyridine nucleotide synthesis.

Amino Acid Metabolism, Inborn Errors↗