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Biomedical subjects

W Remagen

Publications and source records attributed to W Remagen.

At least 55 records · Page 3Linked to original sources
PubMed1979

Ameloblastic fibroma and its sarcomatous transformation.

A case of ameloblastic fibroma, and one of its more aggressive variety, the ameloblastic "fibrosarcoma", are presented. The clinical and morphologic differences are discussed. In our opinion, ameloblastic "fibrosarcoma" is a semimalignant tumor. Therefore we propose "proliferating ameloblastic fibroma" as a more appropriate designation.

Adolescent↗
PubMed1977

Paget's disease with spinal cord compression. Favourable course after decompression and calcitonin treatment in two cases.

Two cases with spinal cord compression due to Paget's disease (osteodystrophia deformans) are reported, which were treated with calcitonin (Salmon Calcitonin) during 12 and 24 months after decompressive laminectomy. Both presented a favourable clinical course with improvement of sensory and bladder disturbances, paraparesis and pain. Diagnostic criteria as X-ray investigation, scintigraphy of bones, biochemical parameters and the long-term treatment whith calcitonin, are discussed.

Calcitonin↗
PubMed1976

Histochemical and electron-microscopic aspects of bone tumor diagnosis.

In recent years, histochemistry and electron microscopy have been applied more and more to the investigation of bone tumors. The contributions and limitations of these methods in differential diagnosis are discussed. The levels of glycosaminoglycans in cartilaginous tumors display distinct differences between slow- and fast-growing types. All cartilaginous tumors are poor in phosphatase activity. Demonstration of these enzymes at acid and alkaline pH in bone-forming conditions reveals differences between benign and malignant tumors. Osteosarcomas display a rich activity of both phosphatases in bone-forming and in bone-free regions. Acid phosphatase may play a rôle in the breakdown of the host tissue infiltrated by the tumor. Electron microscopy of bone tumors has brought out some interesting findings. In fibrous dysplasia a particular kind of very fine fibrillar structures was observed besides the regular collagen fibrils. This may indicate retardation of collagen maturation. Cell organelles in benign and malignant bone tumors usually differ quantitatively. They resemble active fibroblasts. In bone- and in cartilage-forming tumors we observed large quantities of microfilaments in the cytoplasm. Nuclear indentations and invaginations probably indicate increased nuclear activity. The intense acid phosphatase activity demonstrated histochemically seems inconsistent with the low number of lysosomes in the cytoplasm of osteosarcoma cells, but other organelles (Golgi apparatus and vesicles) may also contain the enzyme. Virus-like particles have not been observed in human osteosarcomas up to now. Other authors have observed a correlation between the number of cell organelles and the grade of differentiation, but this was not detected in our sample of benign and malignant cartilaginous tumors. Histochemistry and electron microscopy of bone tumors are still in the early stage of material gathering. Some histochemical findings, however, can already be used as diagnostic tools.

Acid Phosphatase↗
PubMed1975

[Primary osteoma of the patella: a case report (author's transl)].

1. The literature concerning tumours of the patella is briefly reviewed. 2. A case of primary osteoma of the patella is reported. 3. Though a malignant tumour was excluded by roentgenology, age of the patient and localisation, a firm diagnosis could not be made before excision and histological examination of the enucleated tumour. 4. Some considerations concerning the origin of osteomas from the pathological point of view have been made.

Bone Neoplasms↗
PubMed1975

Comparative kinetics of 45Ca and 89Sr in chronic uremic syndrome in the rat.

In rats a chronic uremic syndrome was induced by 5/6 resection and subsequent irradiation of the kidneys. After 5 weeks 45Ca and 89Sr were injected simultaneously, and the different metabolic handling of the two elements was determined applying an open two-compartment model of Calcium kinetics. The uremic animals were compared with two groups of rats which were pairfed, and fed ad libitum, respectively. Besides an elevenfold faster urinary excretion when calculated with Sr, and which was reduced to about one half in the uremic rats, a significant discrimination by bone in favour of Ca was found, with a rather stable factor of 1.2 in the three groups. This is considered to evidence that urinary excretion and bon uptake of Sr are independent processes.

Animals↗
PubMed1975

Comparison of the effects of vitamin D3, dihydrotachysterol, and parathormone on calcium kinetics in the rat.

Rats were treated with 100 I.U. (= 2.5 mcg) Vit. D3/day during 14 days and submitted to a radio-Calcium assay of Calcium kinetics. The results were compared with those obtained in weight-matched pair-fed controls, and with those obtained in former experiments applying dihydrotachysterol and parathormone. Vit. D3, which is transformed to a hormone, increased the fast exchange compartment, the exchange rate between the compartments, the endogenous fecal Calcium excretion rate, and the bone uptake and release rates. These findings indicate that the Vit. D-hormone is more similar in its action to the other hormone, parathormone, than to its close chemical relative dihydrotachysterol.

Animals↗
PubMed1975

Benign osteoblastoma.

The eighth case of a benign osteoblastoma of the jawbones is presented. The tumor showed early recurrence after imcomplete curettage. The tumor-bearing part of the mandible was resected and reconstructed with an autologous bone graft. The histologic features of the entire specimen proved its benighn character. The patient is doing well 2 years after surgical treatment.

Adolescent↗