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Biomedical subjects

W Remagen

Publications and source records attributed to W Remagen.

At least 37 records · Page 2Linked to original sources
PubMed1986

Morphometry of bone. Are parameters from the iliac crest reliable indicators of renal-insufficiency osteopathy?

Bone samples from 25 autopsy cases with chronic renal insufficiency were analyzed stereologically. The findings in the iliac crest were found to be representative of those of the rib, femur condyle and lumbar vertebra for the following stereologic parameters: volume of osteoid seems related to total bone volume [VV(OID/BONE)], surface of osteoid seams related to total bone volume [SV(OID/BONE)] and surface of osteoid seams in relation to trabecular surface [SS(OID/TRAB)]. In addition, the value of various stereologic parameters for the classification of osteopathies was checked.

Aged↗
PubMed1985

Extremity bone tumors: evaluation by P-31 MR spectroscopy.

High-resolution P-31 MR spectra were obtained in four patients with bone tumors of their distal extremities. In one case the tumor, a Ewing sarcoma of the tibia, was investigated during clinical remission after radiation therapy and chemotherapy. The other three cases - one low-grade chondrosarcoma of the tibial head, one malignant fibrous histiocytoma of the tibia, and one chondroblastoma of the medial femoral condyle - showed clinically active tumor growth, with corresponding increased metabolism as demonstrated by bone scintigraphy. The spectra of the three active tumors indicated a comparably high adenosine triphosphate content, similar to previously published spectra from animal tumors or human tumors implanted into animals. There were also high resonances of inorganic phosphate and low resonances of phosphocreatine; there were definite peaks in the phosphodiester and phosphomonoester regions, indicating the existence of these metabolites in the tumors. Slight but definite changes in the metabolite content were observed in one tumor after chemotherapy. The spectra of the unaffected leg did not show any well-resolved P-31 signals, which is typical for healthy bone. These are the first P-31 MR spectra of human bone tumors measured in patients to our knowledge.

Adolescent↗
PubMed1985

High-dose ifosfamide in advanced osteosarcoma.

In a prospective study, 18 evaluable patients with recurrent osteosarcoma were treated with ifosfamide, 1.8 g/m2 daily for 5 consecutive days. Courses were repeated every 4 weeks. Additional mesna (2-mercaptoethane sulfonate) was given to prevent urotoxicity. All patients had measurable lung deposits and all but one had been pretreated with various cytotoxic agents. Six patients (33%) showed therapeutic response, two complete and four partial, with a median duration of 5.5 months (range, 3-47+). Toxicity included myelosuppression, alopecia, nausea, and vomiting. No severe urotoxicity or central nervous system toxicity was observed. Thus, high-dose ifosfamide in combination with mesna seems to be a safe and effective agent for the chemotherapy of osteosarcoma.

Alopecia↗
PubMed1984

Histological results with cement-free implanted hip joint sockets of polyethylene.

The histological appearance of the implant-bone boundary in eight preparations from seven deceased patients in whom a polyethylene acetabulum socket had been inserted without cement between 3 weeks and 3 years previously is described. In all cases, a good or excellent clinical result had been present up to death. All sockets were firmly anchored macroscopically in the bone of the acetabulum. Three zones were defined in accordance with the mechanical strain on the surface of the cup: (a) zone of compression; (b) zone of transition in which mainly shear forces act; and (c) zone of decompression, which corresponds to the region below the "equator." It was noticeable that a layer of connective tissue separated the implant from the bone over almost the entire surface. This layer was very thin in the region of the pressure transfer layer, and thicker in the decompression zone. At sites at which pressure and shear forces act a fibrocartilaginous tissue was found, and the "subchondral" bone was only occasionally in direct contact with the polyethylene surface. At some sites, but above all in the region of the compression zone, very tiny particles that were birefringent in polarized light were found. Either these derive from very fine grindings from the prosthesis surface or they are to be interpreted as a result of "biodegradation" of the polyethylene. This observation permits the conclusion that the biocompatibility of the implant can be improved further by coating the polyethylene surface.

Aged↗
PubMed1983

Primary chronic osteomyelitis.

Plasma-cell osteomyelitis is a histological diagnosis and, in the opinion of some authors, is a disease entity which can be differentiated from the sclerosing osteomyelitis of Garré and Brodie's abscess. Our investigation of 12 patients with plasma-cell osteomyelitis leads us to a different conclusion. The radiological appearances are not specific and do not allow a definitive diagnosis of the type of osteomyelitis or the exclusion of other bone disorders. Although there were always an increased number of plasma cells in the specimens from our patients, there were frequently transitional appearances varying from sclerosing osteomyelitis to Brodie's abscess. For this reason, we suggest that the term "primary chronic osteomyelitis" should be used. This makes it possible to distinguish the condition from acute and secondary osteomyelitis as well as from other diseases, such as bone tumours. All our patients were treated by local resection of the osteomyelitis lesion and they all recovered uneventfully; there were no local recurrences.

Adolescent↗
PubMed1983

[Osteosarcoma of the larynx].

A case of osteosarcoma of the soft tissues of the larynx of a 65 years old man is presented. Adequate surgical excision of the tumour was impossible because the patient had advanced cerebral and coronary vascular disease. Radiation therapy produced no remission of the tumour. The light microscopic findings are described and discussed. This is the sixth recorded case of osteosarcoma of the larynx.

Aged↗
PubMed1982

[Radiologic-pathologic correlations in tumors and tumor-like lesions of the hand (author's transl)].

Since 1972, 267 tumors or tumor-like lesions of the hand in 257 patients were examined at the bone tumor registry by the Swiss Society of Pathology in Basel, Switzerland. This is 9% of a total of 2,800 bone tumors submitted. An analysis revealed 254 benign tumors or tumor-like lesions and 13 malignant tumors, among them 2 metastases of tumors of unknown origin. As expected, enchondromas (n=81) and pigmented villo-nodular synovitis of the tendon sheath (n=104) were the most frequent tumors. All other tumors or tumor-like lesions appeared only as solitary cases or in small numbers. The radiologic characteristics of some of the lesions are reviewed and their histology is presented. Furthermore, some important points of differential diagnosis are discussed.

Bone Cysts↗
PubMed1981

Localization of exogenous 14C-oxalate in rats determined by whole-body- and microautoradiography.

A single dose of 14C-oxalate was given to Wistar rats using a throat probe. The animals were sacrificed and the oxalate distribution was determined using whole-body-autoradiography. The results showed that a large portion of the absorbed oxalate had reached the bladder 30 min after administration. It is possible that this rapid renal excretion could lead to a short-term oxalate peak in the urine. The oxalate also showed a great affinity for bone. This suggests that there is a deep compartment for oxalate in bone. At the light microscopic level, the localization of 14C-oxalate in bone and in the gastric wall was demonstrated using microautoradiography. This appears to show that there is gastric excretion of absorbed oxalate. Further pharmacokinetic investigations are necessary to confirm this conclusion.

Animals↗
PubMed1981

Giant cell tumors in combination with other primary bone tumors.

Three cases featuring the coincidence of 2 different primary bone tumors at the same site are presented. In 2 cases, the combination was not one of giant cell tumor and enchondroma, in the 3rd one, of giant cell tumor and non-ossifying fibroma. The patho-genetical and prognostical problems of these cases are discussed.

Adult↗
PubMed1981

Atypical (dedifferentiated) chondrosarcoma or osteosarcoma with preponderant chondroblastic differentiation?

A bone tumor was detected in the distal right femur of a 15-year-old girl. The age of the patient, the localization, and the X-ray picture were in favor of an osteosarcoma. However, histology was consistent with a "highly differentiated chondrosarcoma with dedifferentiation and focal osteosarcomatous metaplasia". The tumor was resected with preservation of the limb. One year later the tumor recurred, and the leg was exarticulated. Histology was again of the same type, as was the case in a single lung metastasis taken out another half year later. Two series of chemotherapy according to an osteosarcoma protocol had no recognizable effect. An unambiguous diagnosis cannot yet be made.

Adolescent↗
PubMed1980

Anatomical distribution of exogenous 14C-oxalate in the rat by macroautoradiography.

A single dose of 14C-oxalate was given to a group of laboratory rats using a gastric tube. The animals were then killed at intervals of 1/2, 2, 5, 24 and 72 h following oxalate administration and the oxalate distribution was determined using the technique of macroautoradiography. The results showed that a large proportion of the absorbed oxalate was already excreted in the bladder 30 min after administration. The non-absorbed oxalate was found eliminated with the faeces after 24 h. At the same time, 14C-oxalate was demonstrated in the bones; whereas 72 h later no radioactivity could be found anymore. It is conceivable, therefore, that the rapid renal excretion of exogenous oxalate may lead to a short-term oxalate peak in the urine. More importantly, the occurrence of such a urinary oxalate peak could in turn be responsible for crystalluria and stone formation.

Animals↗
PubMed1980

[Demonstration of the uptake of 35S by chondrosarcomas (author's transl)].

Described are two methods of evaluation of the uptake of 35S by chondrosarcomas, i.e. autoradiography and external monitoring of the Bremsstrahlung. A higher concentration of sulfur in the tumor area of three patients was demonstrated after the injection of aliquots of both diagnostic and therapeutic activities. Apart from the simple handling and the quickly obtained results, the external monitoring of the Bremsstrahlung permits quantitative evaluation of the degree of uptake and a simple control over the progress of therapy.

Autoradiography↗