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Biomedical subjects

W Reinhardt

Publications and source records attributed to W Reinhardt.

90 records · Page 5Linked to original sources

Embedding trees in the rationals.

An example is presented of a simple algebraic statement whose truth cannot be decided within the framework of ordinary mathematics, i.e., the statement is independent of the usual axiomatizations of set theory. The statement asserts that every tree-like ordering of power equal to or less than the first uncountable cardinal can be embedded homomorphically into the rationals.

Journal Article↗

The use of recombinant human TSH in a patient with metastatic follicular carcinoma and insufficient endogenous TSH production.

We present a case of a patient suffering from metastatic differentiated thyroid carcinoma (DTC) and insufficient endogenous TSH production suspicious of secondary hypothyroidism. The use of recombinant human TSH (rhTSH) enabled us to administer a therapeutic activity of radioactive iodine (RAI) under maximal TSH-stimulation, achieving a marked decrease in thyroglobulin accompanied by a clinical improvement.

Adenocarcinoma, Follicular↗

Skeletal immaturity, IGF-I and IGFBP-3 serum concentrations in Legg-Calvé-Perthes disease (skeletal immaturity, IGF-I and IGFBP-3 in LCPD).

BACKGROUND: Skeletal immaturity is a major feature in Legg-Calvé-Perthes disease (LCPD). Evaluation of growth hormone concentration, somatomedin activity, or insulin-like growth factor I (IGF-I) concentration revealed inconsistent results. Recently, IGF-binding protein 3 (IGFBP-3) was found normal in relation to chronological age in LCPD patients. PATIENTS: In this study IGF-I and IGFBP-3 were measured in the serum of 23 children with unilateral LCPD and in 23 sex and age matched controls. METHODS: IGF-I and IGFBP-3 were measured with radioimmunoassays, using an IGF binding site-blocked assay for IGF-I. The results were related to the chronological age in all and to the bone age in 19 of the patients. RESULTS: Bone age was retarded in 16 of 19 patients with a delay of one year or more in twelve children (mean 14.75, range 2-35 months). Chronological age and bone age related IGF-I and IGFBP-3 serum concentrations were predominantly within the normal ranges and did not differ significantly from the matched controls. IGF-I and IGFBP-3 serum levels showed a high correlation, which was similar in LCPD (r = 0.7; p < 0.0001) and in the control group (r = 0.8; p < 0.0001). CONCLUSIONS: Our data confirm that most children with LCPD are skeletally immature. However, IGF-I measured with IGF-II-blocked IGFBP binding sites, and IGFBP-3 serum concentrations analysed with respect to bone age show no evidence for a disturbance of the hypothalamo-pituitary-somatomedin axis in these children.

Age Determination by Skeleton↗

[Influence of non-diabetic pregnancy on fructosamine and HbA1c concentration].

HbAIc and fructosamine concentrations were measured in the course of 177 nondiabetic pregnancies and compared with the corresponding values of 24 nondiabetic nonpregnant women. In all three trimesters HbAIc and fructosamine were significantly lower than the corresponding values in the nonpregnant women; HbAIc: 1st trimester 4.77 +/- 0.62%, 2nd trimester 4.38 +/- 0.59%, 3rd trimester 4.33 +/- 0.49%, p < 0.01; fructosamine 1st trimester 2.13 +/- 0.17 mmol/l, 2nd trimester 2.02 +/- 0.15 mmol/l, 3rd trimester 1.90 +/- 0.15 mmol/l, p < 0.01; nonpregnant women: HbAIc 5.13 +/- 0.41%, fructosamine 2.53 +/- 0.17 mmol/l. However, if the fructosamine is correlated to the respective total protein concentration a constant value results for the course of pregnancy. The changes in the HbAIc and fructosamine concentrations in pregnancy should be taken into account when treating pregnant diabetics.

Adult↗