Search PubMed⌕ Search

Biomedical subjects

W Raab

Publications and source records attributed to W Raab.

At least 55 records · Page 3Linked to original sources
PubMed1981

Glucose-6-phosphatase dehydrogenase activity in rat urine. Changes following kidney damage (short report).

In rat urine, G-6-PDH activity is regularly present. Following the administration of nephrotoxic substances (D-serine, tetrathionate), or after elicitation of vascular shock (hypoxic kidney damage), a statistically significant increase in urinary G-6-PDH activity occurs. The alterations in urinary G-6-PDH activity largely correspond to the changes in urinary AP activity which, in this study, was determined in all of the experiments.

Alkaline Phosphatase↗
PubMed1980

[Effect of imidazole derivatives on various numbers of microbes to determine microbial sensitivity].

Imidazole derivatives with antifungal activity were investigated in their effects on concentrated and diluted suspensions of Saccharomyces cerevisiae, Candida albicans, and Staphylococcus aureus haemolyticus. Against Candida albicans, activity of the imidazol derivatives was higher in diluted suspensions than in concentrated suspensions: this fact proves the presence of a microbe-count sensitivity. Against Saccharomyces cerevisiae and Staphylococcus aureus haemolyticus, no microbe-count sensitivity of clotrimazole, econazole nitrate, ketoconazole, or N-148/76 could be detected by Warburg assay on resting microbes.

Candida albicans↗
PubMed1980

[Interactions between amphotericin B and hydroxytetracycline].

By means of the Warburg assay (manometric technique), investigations were performed to elucidate interactions between amphotericin B, a polyene antifungal antibiotic, and hydroxytetracycline. Those two compounds were combined in clinical therapy. On resting yeasts and bacteria, interactions could be ruled out. On the contrary, on both types of microbes a significant increase in antimicrobial actions could be seen in the presence of the second substance. The antimycetic activity of amphotericin B was significantly increased in the presence of hydroxytetracycline (in five-fold concentrations). The antibacterial activity of hydroxytetracycline was significantly higher in the presence of amphotericin B (same concentrations). The clinical implication of these results is briefly discussed.

Amphotericin B↗
PubMed1980

[Effect of long-wave ultraviolet light (UV-A) and medium-wave ultraviolet rays (UV-B) on human skin. Critical comparison].

When discussing the effects of ultraviolet radiation on human skin, one should carefully distinguish between the long wave ultraviolet light (UV-A) and the short wave radiations (UV-B and UV-C). Ultraviolet A induces immediate pigmentation but, if high energies are applied, a permanent pigmentation is elicited. This type of ultraviolet A-induced pigmentation has been called "spontaneous" pigmentation as no erythematous reaction is necessary to induce or accelerate melanine formation. Ultraviolet B provokes erythema and consecutive pigmentation. Upon chronic exposure, ultraviolet B causes the wellknown actinic damage of the skin and even provokes carcinoma. With exposures to the sunlight (global radiation), one should be most careful. The public must be informed extensively about the dangers of excessive sunbaths. The use of artificial "suns" with spectra between 260 and 400 nm is limited as it may cause the same type of damage as the global radiation. An exact schedule for use of artificial lamps is strongly recommended. After one cycle of exposures, an interruption is necessary until the next cycle of irradiations may start. Upon continual use for tanning of the skin, artificial lamps may provoke irreversible damage of the skin. Radiation sources with emission spectra of wavelengths between 315 and 400 nm exclusively are well suited for the induction of skin pigmentation (cosmetic use). Potent radiation such as UVASUN systems provoke a "pleasant" permanent pigmentation after exposures for less than one hour. The use of ultraviolet A (UV-A) does not carry any risk for the human skin.

Amino Acids↗
PubMed1980

Nephrotoxicity of drugs, evaluated by renal enzyme excretion studies.

Via various pathways, urinary enzymatic activities are changed by drugs. Nephrotoxic effects may be determined by such investigations. Numerous experimental series have formed the basis for the clinical application of this method. The pertinent data collected with analgesics and antibiotics, alone or in combinations, are discussed in this paper. The data from the literature were compared with personal investigations, in animals as well as in man. It is concluded that - under certain precautions - the nephrotoxicity of drugs can be evaluated by renal enzyme excretion studies.

Analgesics↗
PubMed1980

[Increase in alkaline phosphatase activity in small intestine mucosa in high fat diets].

The activity of alkaline phosphatase in small intestine mucosa was increased by about 40% in rats adapted to a high fat diet in comparison to high-carbohydrate-adapted animals. As high fat-feeding leads to an increase in the intestine's capacity to absorb fat, this finding is consistent with the hypothesis that alkaline phosphatase in the small intestine epithelium plays a role in fat absorption.

Alkaline Phosphatase↗
PubMed1979

Investigations on the action of cefazedone and gentamicin, alone and combined, on renal enzyme excretion in rats.

Administration of (6R, 7 R)-7-(2-[3,5-dichloro-4-oxo-1(4 H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl)-8-oxo-5-thia-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid (cefazedone, Refosporen) in a dose of 1000 mg/kg led to a statistically significant rise of the alkaline phosphatase activity in rat urine. The excretion of leucinaminopeptidase activity was not significantly affected. The enzyme activity in the animals' urine was raised by the administration of 100 mg/kg of gentamicin. Combined administration of the two antibiotics in the doses mentioned did not lead to any additive action. The established increases in activity were in the same range as after the administration of only one of the antibiotics.

Alkaline Phosphatase↗
PubMed1978

D-penicillamine and enzymatic activities.

The influence of incubation with D-penicillamine on pure enzyme preparations and on enzymatic activities of serum and skin homogenates was investigated. Three of the nine enzymatic activities studied underwent significant changes. Such effects of D-penicillamine must be taken into consideration if therapeutic or unwanted actions of this drug are to be fully understood; they are elicited by concentrations reached under conditions used for human therapy.

3',5'-Cyclic-AMP Phosphodiesterases↗
PubMed1978

[Allergy and anaphylaxis].

Acute undesirable drug reactions following the application of one of the modern amiglycoside antibiotics only occur in some exceptional cases. Those compounds reveal low sensitizing capacity, in contrast to streptomycin. Following topical applications, allergies of delayed type have been recorded, especially in the case of neomycin, a widely used topical antibiotic. Aminoglycosides exhibit anaphylactoid activity; they cause a degranulation of mast cells. Via this mechanism, histamine reactions are provoked. Such "anaphylactoid" reactions are clinically indistinguishable from true allergic (anaphylactic) phenomena and repeatedly have been erroneously interpreted. For allergological test series as well as for the correct interpretation of acute unwanted drug effects it is important to consider the anaphylactoid activity of the aminoglycosides.

Aminoglycosides↗