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Biomedical subjects

W Permanetter

Publications and source records attributed to W Permanetter.

At least 37 records · Page 2Linked to original sources
PubMed1990

Diagnostic significance of carcinoembryonic antigen in the differential diagnosis of malignant mesothelioma.

The histologic and cytologic distinction of malignant mesothelioma from carcinomas metastatic to the pleura or peritoneum is often problematic. For this reason immunologic methods are being increasingly used as diagnostic adjuncts. This review summarizes 40 studies on the expression of carcinoembryonic antigen in mesotheliomas and in lung and other carcinomas involving the pleura or peritoneum. Carcinoembryonic antigen was identified immunohistochemically in 11% of mesotheliomas and in 84% of carcinomas examined and immunocytochemically (in serous effusions) in 4% and 58%, respectively. In serum and in pleural or ascitic fluid, significantly elevated levels of carcinoembryonic antigen are commonly associated with (lung) carcinomas but rarely with mesotheliomas. Thus, together with identification of the antigen in serum, pleural fluid, or ascitic fluid, immunohistochemical and immunocytochemical techniques for detecting carcinoembryonic antigen provide a valuable aid for distinguishing malignant mesothelioma from metastatic carcinomas.

Biomarkers, Tumor↗
PubMed1989

MR imaging of the breast with Gd-DTPA: use and limitations.

Between August 1985 and November 1987, 150 patients with 167 biopsy-proved lesions were examined with magnetic resonance (MR) imaging enhanced with gadolinium diethylenetriaminepentaacetic acid, mammography, and palpation. Of these patients, 113 with 123 lesions were also examined with ultrasound. Enhancement above 300 normalized units (NU) on MR images was considered significant; between 250 and 300 NU, borderline; and below 250, nonsignificant. All 27 fibroadenomas and 70 of 71 carcinomas showed significant enhancement; one carcinoma showed borderline enhancement. Nonproliferative dysplasia showed nonsignificant enhancement in 15 of 16 cases and significant enhancement in one, whereas proliferative dysplasia showed usually diffuse enhancement varying from nonsignificant (five of 30 cases) to borderline (five of 30 cases) to significant (20 of 30 cases). In the nonblind evaluation of the modalities, MR imaging compared favorably. When limitations of the technique were considered, MR imaging seemed beneficial as a supplement in selected, diagnostically difficult cases.

Adenofibroma↗
PubMed1989

[The value of computerized tomography in detecting and localizing lung metastases].

25 patients with an extrathoracic malignant tumor and radiologically proven lung nodules had a thoracic CT preoperatively. 111 nodules were confirmed by surgery (median: 10 mm). Histopathological examination revealed 104 metastases or sterilised metastases and 7 benign nodules. CT detected 97% of the nodules. Localisation of the nodules according to different lobes or segments was correct in 97% of nodules. CT is a very sufficient method for the detection and localisation of lung metastases.

Adolescent↗
PubMed1989

[Computer-assisted tissue analysis for cancer detection in breast ultrasound--significance of reference values].

Due to the inhomogeneous and very variable structure of healthy tissue of the female breast it is often very difficult to detect a carcinoma via computer-aided sonography. The present study based on preoperative measurements in 29 woman patients with carcinoma of the breast aimed at finding out to what extent it would be possible to circumvent this problem by means of additional reference measurements in healthy tissue. For this purpose, relative image parameters were determined besides absolute ones from measurements in tumorous and healthy reference tissue. These relative image parameters are much more suitable for subsequent decision analysis on account of their narrower range of variation. The results obtained in this manner could be improved further by additional optimization or extension (such as analysis of other combinations of parameters, by enlarging the field of measurement and hence the data available per tissue sample, use of higher or even different ultrasound frequencies).

Adipose Tissue↗
PubMed1988

[Recurrence of Wilm's tumor following a 9-year disease-free interval].

We report the case of a 25-year old female patient, who presented with intrapulmonary metastases of a Wilms' tumor nine and a half year after initial therapy of a stage I tumor with surgery, local radiation and combined chemotherapy. In general, relapses of Wilms' tumor occur within two year after nephrectomy. Recurrences after more than 7 years are very rare. A relapse of a Wilms' tumor in an adult patient after more than 9 years is not yet published. We treated our patient according to the therapeutic procedure, which is recommended by the National Wilms' Tumor Study as curative treatment of relapses in childhood: complete resection of pulmonary metastases, irradiation of the whole lunge and repeatingly combined chemotherapy with actinomycin D and vincristin. The patient is doing well without evidence of tumor 13 months after thoractomy. A short review of the literature is given.

Adolescent↗
PubMed1988

Pharmacokinetics of methotrexate during regional hyperthermia in a pig model.

In the pig model, regional hyperthermia in the gluteus was combined with the infusion of 150 mg MTX over a period of 100-120 min. The pharmacokinetic data reveal that this approach is capable of simulating the situation that is necessary and achievable in medium-dose MTX therapy of human tumours. Under MTX infusion, serum levels in the region of 10(-5) M are attained. As an expression of a renal and hepatic MTX excretion, high levels of MTX are found both in the urine and in the bile. Especially high concentrations of MTX are found in the liver and kidney tissue. In the normothermic and hyperthermic muscle, very low MTX levels are found. The pharmacokinetic data obtained show that the selected model is suitable for the future investigation of the effect of regional hyperthermia and MTX on transplanted tumours.

Animals↗
PubMed1988

[Percutaneous biopsy technic. Aspiration fine needle and cutting biopsy cannula in an experimental comparison].

Guided percutaneous biopsy for cytological or histological diagnosis is well tried. Various types of needles and calibres are available. Only few studies have been performed comparing different needle configurations. Fine needles and cutting needles were evaluated quantitatively and qualitatively in an experimental study obtaining specimens of resected tumours. Weight measurement and preservation of the material were analysed. Material for cytological diagnosis was obtained with all types of needles. Increasing needle size resulted in higher yield of diagnostic tissue. Small-bore cutting needles having an acute bevel angle provide better results in soft or semiliquid tissue. It is not necessary to increase the needle size over 18 gauge.

Biopsy, Needle↗
PubMed1988

[Transthoracic excisional biopsy of focal pulmonary lesions].

The results of percutaneous, fluoroscopically-guided cutting biopsies of focal pulmonary lesions in 126 patients were evaluated retrospectively. In 90% of malignant lesions an exact diagnosis could be made from the material obtained. In 40% of the malignant lesions, histological examination was possible, in addition to cytology. In 87% of these, there was agreement between histology and cytology. Of the cases coming to surgery, 84% of the biopsies proved correct. Specificity was 100%. Multiple punctures were necessary in only 13%. Significant complications occurred in 5%. The cutting biopsy technique has the advantage of producing more biopsy material suitable for histology.

Biopsy, Needle↗
PubMed1988

Tumour associated antigens in diagnosis of serous effusions.

The use of tumour associated antigens in the diagnosis of serous effusions was studied in 76 patients with benign and 200 patients with malignant disease. Tissue polypeptide antigen (TPA), alpha fetoprotein, and CA 125 were found to be of little value. At cut off points of 3 ng/ml, 10 U/ml, and 30 U/ml, respectively, carcinoembryonic antigen (CEA), biliary glycoprotein I (BGP I), and CA 19-9 discriminated between benign and malignant serous effusions with a sensitivity of between 24% and 67%. The immunocytochemical staining for these markers resulted in malignant cells being detected in 18% to 33% of cases. Various combinations of conventional cytological examination, effusion fluid tumour marker determination, and immunocytochemical analysis identified malignant cells in serous effusions in up to 72% of cases; conventional cytology alone detected tumour cells in only 30%.

Antigens, CD↗
PubMed1988

[Dynamic contrast medium studies with flash sequences in nuclear magnetic resonance tomography of the breast].

In this study the dynamic contrast behavior after Gd-DTPA of different breast tissues and tumors has been investigated with a series of T1-weighted FLASH-sequences during the first 5 minutes after the application of Gd-DTPA. The results of these dynamic FLASH-measurements have been compared to the results of the SE-sequences 6-10 and 11-15 minutes after Gd-DTPA in 40 patients with 54 different breast tissues. It could be shown that in a number of cases a better differentiation (e.g. DD between carcinomas and proliferative dysplasia) was possible on FLASH-scans early after contrast medium than on the late SE-scans. Only the distinction between non-proliferative and proliferative dysplasia was better on the late SE-scans. Evaluation of the enhancement dynamics may be helpful in some cases as an additional information. Further investigations are necessary to confirm these findings and to assess their value.

Breast↗
PubMed1988

[Fine-needle and incisional biopsy technics in the percutaneous puncture of abdominal space-occupying lesions].

Cutting needles for guided percutaneous biopsy of abdominal tumors have been introduced in recent years and provide better results than fine-needle aspiration. A total of 292 biopsies in 273 patients were evaluated retrospectively. The diagnostic accuracy was 83.4% with cutting needles and 54.4% for fine-needle aspiration. The sensitivity in detection of malignancy was 86.8% and 88.6%, respectively. The location of the lesion to be biopsied determined whether CT or US was used for guidance. US control was used in biopsies of the upper abdomen; CT was preferred for guidance in the retroperitoneal space and in the pelvis. The caliber of the cutting needles in transperitoneal or transintestinal biopsy was limited to 19 gauge. The complication risk using cutting needles up to 18 gauge is no higher than for fine-needle aspiration biopsy if suitable access routes are selected.

Abdominal Neoplasms↗
PubMed1987

[Recurrent menstruation-associated pneumothorax--catamenial pneumothorax].

The case of a 28-year old patient with a rare complication of an extensive endometriosis externa is described. A spontaneous pneumothorax occurred on 3 occasions corresponding each time with the start of the menstrual period. The various hypotheses on the aetiology and treatment of this rare condition are reviewed. To date only 65 patients with this interesting clinical entity have been recorded.

Adult↗
PubMed1987

[Sonographic diagnosis of fetal liver cysts].

The authors report on prenatal ultrasonic diagnosis of foetal liver cysts with a massively thickened and cystic placenta in the twenty-third week of pregnancy. Karyotyping and serological examination of foetal blood samples of the umbilical vein gave normal results. The liver cysts were tapped twice subsequently, because they displaced other foetal abdominal and thoracic organs. In the thirty-fifth week of pregnancy the foetus died due to malnutrition resulting from the changes of the placenta, the origin of which remained unclear.

Adult↗
PubMed1987

Influence of postdiabetic onset time and immunosuppressive treatment on islet grafts in the spontaneous diabetic BB/W rat.

1000 islets from one donor, isolated with a modified neutral red method, were intraportally transplanted from BB/Wistar or Lewis (RT1) donors to short- and long-term diabetic BB/Wistar recipients. Recipients received immunosuppression with cyclosporine i.m.--either postoperative 4 X 25 mg/kg body weight or pre- and postoperative 3 X 10 mg and 4 X 25 mg/kg body weight. Graft survival in short-term diabetic recipients was significantly shorter than in long-term diabetics, whether they were immunosuppressed or not. Especially in recent onset recipients, the additional preoperative immunosuppression with cyclosporine provided longer graft survival than postoperative cyclosporine alone. Histological examinations of islet grafts showed eosinophilic cells in all transplanted islets, in both functioning and clinically rejected grafts of allogenic and "pseudoisogenic" transplanted recipients. a coincidence of eosinophilic cells with the reenactment of the original autoimmune disease in islet grafts seems possible.

Animals↗