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Biomedical subjects

W Oosterlinck

Publications and source records attributed to W Oosterlinck.

At least 91 records · Page 5Linked to original sources
PubMed1986

Screening of chelating agents for chemolysis.

The solubility of calcium oxalate monohydrate and calcium hydroxyapatite was calculated as a function of pH in the presence of different chelating agents and was compared with the solubilities in EDTA- or CDTA-containing solutions. An analysis of the solubility curves for 19 chelating agents showed that 5 of the complexing agents considered result in a high solubility for calcium phosphate and oxalate at pH 8 or higher. For these complexing agents the solubility curves of struvite were also calculated. EGTA and HEDTA showed rather low solubilities for struvite due to their low tendency to form complexes with magnesium. On the basis of the calculated solubility curves, the expected litholytic effectiveness for the inorganic kidney stone compounds could be classified in the following decreasing order: CDTA approximately equal to EDTA approximately equal to EGTA greater than EEDTA greater than DTPA greater than UDA approximately equal to HEDTA. With the exception of EGTA and HEDTA for struvite stones, solutions based on these compounds show high solubilities for all the inorganic kidney stone compounds at a solution pH of 8 or higher and therefore have good prospects as litholytic agents.

Chelating Agents↗
PubMed1986

Antireflux in adults: a long-term follow-up.

The long-term results after antireflux operation in 47 adults are presented. Reflux was eliminated in all but 3 cases. Preoperatively most patients complained of urinary tract infection with or without fever, but sometimes investigation for hypertension or urolithiasis also led to the diagnosis. Postoperatively 70% of the patients are free of symptoms and infection. Renal scarring in pyelonephritic patients seems to stop after intervention. In all patients with a normal preoperative creatinine level, this level stays normal after the intervention. However, in 6 of 7 patients with a creatinine level of greater than 1.5 mg% before operation, the intervention could not stop the evolution toward terminal renal failure.

Adolescent↗
PubMed1986

Clinical follow-up.

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Carcinoma in Situ↗
PubMed1985

Captopril: a protective agent in renal warm ischemia in rats.

Captopril, an angiotensin-converting enzyme inhibitor, was used as a protective agent before and after 90 min of renal warm ischemia in rats. At a dose of 1 mg/kg, it was able to lower the postoperative serum creatinine values significantly (from 6.3 to 2.5 mg% on the 2nd postoperative day) in unilaterally nephrectomized animals. Increasing the dose to 4 and 8 mg/kg or combining captopril with hypertonic mannitol (10 ml/kg of a 15% aqueous solution) did not improve these figures significantly. The same magnitude of protection was obtained when captopril was given either before or just after the ischemia. In terms of mortality the differences among unprotected and protected groups were very important: only 6 of 24 unprotected animals survived the 5th postoperative day while 42 of 44 protected animals survived.

Animals↗
PubMed1985

Solubility of inorganic kidney stone components in the presence of acid-base sensitive complexing agents.

Computation methods used to calculate the solubilities of the main inorganic kidney stone components in the absence or presence of acid-base-sensitive complexants as a function of pH are described. The solubilities of whewellite, brushite, whitlockite, octocalcium phosphate, hydroxyapatite and struvite were calculated in the presence of ethylenediaminetetraacetate (EDTA), trans-cyclohexane-1,2-diaminetetraacetate (CDTA), citrate, tripolyphosphate and alpha-hydroxyisobutyrate. The results explain why kidney irrigations with citrate give extremely variable results. The calculated solubility curves show that only EDTA and CDTA solutions with a pH of 8 or higher will have good litholytic properties for all compounds concerned. The computation methods presented in this paper can be used to calculate the solubility of a large number of salts. These salts may contain non-acid-base-sensitive cations capable of forming complexes, acid-base-sensitive anions, hydroxyl ions, hydrogen ions or other acid-base-sensitive cations (e.g. NH4+), and the solubilities can be calculated in the presence or absence of acid-base-sensitive complexing agents.

Calcium Oxalate↗
PubMed1985

[Balanopreputial hypospadias].

Magpi's technique is described. It is an excellent procedure for the cure of the majority of cases of coronal or just subcoronal hypospadias, but its use is contra-indicated in the presence of a very large meatus, a thin, transparent, distal urethra, or a deeply grooved glans. In these cases, other techniques are required.

Follow-Up Studies↗
PubMed1984

Ciramadol, a new potent analgesic, used intravenously in renal colic.

In an open investigation, ciramadol, a partial agonist of opioid, was found to be a potent analgesic when 20 mg was given intravenously to 30 patients experiencing severe pain of renal colic. Total pain relief was obtained in 9 patients, while very good pain relief was obtained in 17 others. However, severe pain was experienced again in 7 of them after 1 to 2 hours. Vomiting and nausea occurred in 9 patients, and dizziness was present in 7 patients. The haemodynamic equilibrium was not changed by the analgesic.

Adult↗
PubMed1984

Preliminary pharmacokinetics of intravenous ciramadol in humans.

Plasma concentrations of ciramadol were measured after intravenous administration of 30 mg in 8 healthy volunteers. A high-performance liquid chromatographic method with U.V.-detection for simultaneous determination of the substance and of its desmethyl metabolite was developed. The disposition of the drug in these volunteers could be described by a two-compartment open model. Distribution volume was on average 561, elimination half-life 3.85 hours and mean body clearance 154 ml/min. Desmethylciramadol was not detected in the plasma.

Adult↗
PubMed1983

Early adjuvant adriamycin in superficial bladder carcinoma.

A multicenter study was performed in 110 patients with superficial transitional cell carcinoma of the bladder. Adriamycin (50 mg/50 ml) was administered intravesically within 24 h after transurethral resection of TA-T1 (O-A) bladder tumors. Instillation was repeated twice during the first week, then weekly during the first month and afterwards monthly for 1 year. The tolerance was evaluated in these 110 patients, and 29 patients presented with local side-effects. In 24 of these patients chemical cystitis was severe enough for them to drop out of the study. No systemic side-effects were observed. Recurrence was studied in 82 evaluable patients after 1 year of follow-up and in 72 patients followed for 2-3 years (mean 32 months). Of the 82 patients studied after 1 year, 23 had primary and 59 recurrent disease. Of the 82 evaluable patients, 50 did not show any recurrence after 1 year (61%), while 32 presented with one or more recurrences (39%). Of these recurrences, 27 were T1 tumors while five progressed to more highly invasive lesions. In patients that were free of recurrence during the first year, 80% remained tumor-free during the 2- to 3-year follow-up period. Of the patients developing one or more recurrences during the first year, only 50% presented with further recurrence once the instillations were stopped. The beneficial effect of Adriamycin appears obvious and might be related to the drug itself, the early and repeated instillations after TUR, or both.

Carcinoma, Transitional Cell↗
PubMed1983

The use of the bladder wash-out test in patients with spinal cord lesions who have urinary tract infection.

In 42 patients with a spinal cord lesion and chronic urinary tract infection the bladder wash-out test was performed to locate the site of infection. The test was easy to perform and no complications occurred. The test could not be performed in only one patient. Differentiation between upper and lower urinary tract infection was possible in 36 patients (43 tests). By using the test, precise treatment was possible for 23 patients, of whom 17 were cured.

Adolescent↗
PubMed1983

Evaluation of 99mTc-dimercaptosuccinic acid renal uptake as an index of individual kidney function after acute ureteral obstruction and desobstruction. An experimental study in rats.

The evolution of the 99mTc-dimercaptosuccinic acid (DMSA) renal uptake is followed after ligation of the right ureter in rats. The DMSA uptake falls rapidly from 35% before ligation to 13% after 24 h, and decreases further to 1.5% after 31 days. The ligated ureter was desobstructed after 10, 17, 24 and 31 days, respectively, DMSA uptake was controlled 4, 11 and 18 days after desobstruction. In the first group, deobstruction after 10 days, the DMSA uptake rose from 7 to 15%, while in the fourth group it rose from 1.5 to 2%. It is concluded that DMSA uptake provides a reliable index for renal function after acute urinary tract obstruction in rats. If the DMSA uptake has fallen below 4% very little renal function can be expected to be regained, whereas above 4% the function can improve considerably.

Acute Disease↗