Syntheses and anti-inflammatory and analgesic activities of hydroxamic acids and acid hydrazides.
Explore the source record for details and available documents.
Animals↗
Biomedical subjects
W Mori
Publications and source records attributed to W Mori.
Possibly unique subunit(s) of human ferritins responsible for tissue specificity.
The biochemical characteristics of human placental and hepatic ferritins were compared. By DEAE cellulose column chromatography, placental ferritin was found to contain more acidic isoferritins, while hepatic ferritin was richer in basic isoferritins. The electrofocusing patterns of subunits revealed that placental ferritin contained at least one unique subunit on the acidic side and might lack one subunit on the basic side as compared with hepatic ferritin. It is hypothesized that microheterogeneities, immunological as well as biochemical, existing between placental and hepatic ferritins cannot be explained merely in terms of different proportions of known acidic and basic subunits, but appear to have resulted from the existence of the unique acidic subunit of placental ferritin and possibly also a unique basic subunit of hepatic ferritin.
Chromatography, DEAE-Cellulose↗
Morphological behavior of carcinoma of the pancreas. 2. Argyrophil cells and Langerhans' islets in the carcinomatous tissues.
The incidence and the behavior of endocrine cells in carcinomatous tissues were studied in 84 autopsy cases and 10 surgical or autopsy cases of pancreatic carcinoma, by light and electron microscope, respectively. It was found that the islets persistently survived in the carcinomatous tissues. In large duct type carcinomas, the islets showed unique familiarity with the carcinomatous ducts, which may be interpreted as suggesting interactions between ductal cells and islet cells in pancreatic carcinogenesis. Aside from these survivor islet cells, carcinomas exhibited different degree and kind of differentiation to endocrine cells, depending upon their histological types. Namely, neoplastic argyrophil cells were found at the incidence of 82% (large duct type carcinoma), 39% (small duct), 43% (adenosquamous), and 18% (undifferentiated one). Moreover, argyrophil cells with their apexes stretching far to the neoplastic lumen were found only in large duct type carcinoma and cystadenocarcinoma. In three cases of carcinoid or oat cell type carcinoma, argyrophil cells were diffusely scattered and irregular in shape. These findings further justify the classification, reported in the previous article. The differentiation to endocrine cells was confirmed also by electron microscope.
Adenocarcinoma↗
Novel inclusion body in hepatitis-related liver cirrhosis.
Luxol fast blue (LFB) was found to stain inclusion bodies in liver tissue which was considered to have been infected by hepatitis virus. There were two types of inclusion bodies, which were quite similar in morphology but showed somewhat different stainability by several dyes. One was confirmed to be hepatitis B surface antigen (HBsAg), but the other was definitely not, as far as can be determined by the best present-day immunological and histological techniques. The latter was found less commonly in the liver of unselected, consecutive autopsy cases (which included some cases of hepatitis), rather commonly in cirrhotic liver without any trace of hepatitis B virus infection, and with extremely high incidence in liver carrying HBsAg. Electron microscopic examination of the liver with inclusion bodies of this type disclosed unfamiliar structures which resembled virus-like particles at the same area as LFB positivity. The significance of the novel inclusion body revealed by LFB stain in the liver is not clear at present. However, it could be interpreted as a morphological manifestation of non-A non-B hepatitis virus infection, if there are two types of human hepatitis viruses, B and non-A non-B, which are very closely related intrinsically or produce some common product(s) in infected hepatic cells.
Hepatitis B Surface Antigens↗
Morphological behavior of carcinoma of the pancreas. 1. Histological classification and electron microscopical observation.
A total of 84 autopsied and 10 operative pancreatic carcinoma cases were studied to investigate their morphological behavior, by light and electron microscopies. The autopsied materials were classified into 70 duct cell carcinomas, 11 undifferentiated carcinomas including 2 giant cell carcinomas simulating giant cell tumor of bone, and 3 endocrine cell carcinomas which might be called carcinoid or oat cell carcinoma. No acinar cell carcinoma was found. Duct cell carcinomas were further subclassified into 37 large and 24 small duct-forming adenocarcinomas, 8 adenosquamous carcinomas, and 1 cystadenocarcinoma. The majority of undifferentiated carcinomas were considered to be of ductal or ductular cell origin. Rare tumors, such as cystadenocarcinoma, giant cell carcinoma, and endocrine cell carcinoma, were shown as case presentations. Electron microscopic features of duct cell carcinoma and its related findings were also presented. These studies should be pursued, because it may be important clinically and disclose, in the future, possible differences in etiology or effective therapeutic agents among the categories, although the classification, made from a viewpoint of histogenesis, did not reflect prognostic differences at the present.
Adenocarcinoma↗
Summary of United States--Japan Cooperative Seminar on Human Hepatocarcinogenesis, January 20-22, 1983, in Honolulu, Hawaii.
Explore the source record for details and available documents.
Carcinoma, Hepatocellular↗
Statistical study on fulminant liver disease in Japan.
Autopsy cases of fulminant liver disease, a pathological group of hepatic lesions which correspond to the clinical entity of fulminant hepatic failure, were collected from the 'Annual of the Pathological Autopsy Cases in Japan' (1969-1978) and analyzed. The total number of cases reviewed in this paper was 239,414, among which 1,000 (0.42%) were considered to match the above category of hepatic disease. Further analysis was carried out on these 1,000 cases, and the results were as follows. Clinical and pathoanatomical diagnoses which had actually been given in these cases covered a wide range. The incidence showed no chronological change or geographical variation in Japan. The age of patients was distributed widely, and there was no sex difference in incidence. Concerning the occupation or background of patients, a considerable number were medical and paramedical personnel. The liver weight was less than normal in most cases, but there were some exceptional cases in which the liver was found to be hypertrophied. As complications many kinds of lesions were found in various organs of the body; hemorrhage, acute inflammation, and necrosis of various viscera were noticed in many cases.
Adolescent↗
Morphological lesions of the pancreatic ducts. Significance of pyloric gland metaplasia in carcinogenesis of exocrine and endocrine pancreas.
Morphological lesions of the pancreatic ducts were studied in 113 control autopsy cases, and 84 cases of primary pancreatic carcinoma. The lesions were classified into pyloric gland metaplasia, focal pseudo-proliferation, goblet cell metaplasia, squamous metaplasia, and atypical proliferation. Diabetes mellitus or glycosuria, alcohol intake, and smoking do not seem to have any close associations with these lesions or pancreatic carcinoma. Pyloric-gland and squamous metaplasias were found at nearly comparable incidences both in control and carcinoma cases, but marked atypical proliferations, which were indistinguishable from carcinoma in situ or intraductal spreading of carcinoma, were more frequently observed in the carcinoma cases. Pyloric gland metaplasia was the most common among the various lesions, and considered to represent nonspecific change of the pancreatic duct. However, it was suggested that some of the metaplastic lesions might be transformed into atypical proliferations and further into carcinoma in situ. The expected latent period from the appearance of in situ lesion to overt pancreatic carcinoma may be a clue to early diagnosis and effective surgical treatment, but possible multiplicity of carcinoma in situ or intraductal spreading of carcinoma even at its early stage will burden further problems on its treatment. On rare occasions, argyrophil cells were found in the pyloric gland metaplasia, and its significance was discussed in relation to the genesis of Zollinger-Ellison tumor.
Adult↗
Pituitary-adrenal axis in pinealoma.
Autopsy series of 19 patients with pineal and anterior third ventricle (suprasellar) tumors were analyzed with regard to shift in pituitary-adrenal axis. Germinomas formed the most common subgroup in this series (79%). Metastatic tumor growth in the pituitary gland caused adrenal atrophy in 4 cases. Some patients with pineal neoplasms had larger adrenals in weight compared with age- and sex-matched controls of Japanese. In three patients with sexual precocity, adrenal weight was larger. It is concluded that clinical importance exists in anterior pituitary insufficiency with adrenal atrophy, but hyperfunction of the hypophyseoadrenal system might occur during the course of the disease.
Adolescent↗
Pathology of liver cirrhosis and hepatocellular carcinoma. Recent studies by Japanese workers.
Recent studies by Japanese workers on the classification of liver cirrhosis, relationship between liver cirrhosis and hepatocellular carcinoma, and pathology of hepatocellular carcinoma were reviewed. It was found that many systems of classification of liver cirrhosis were in current use in different parts of the world and it was recommended to use the classification of types A, B, and C in this country. An interesting fact was that there was a difference in the frequency of hepatocellular carcinoma-association in liver cirrhosis but not in cirrhosis-association in hepatocellular carcinoma between Japan and western countries. Although there were some attempts to classify hepatocellular carcinoma grossly and histologically, we do not still have any universally accepted classification. On the other hand, introduction of enzyme- and immuno-histochemistry, electron microscopy and nonimmunogenic staining of Hepatitis B antigen seemed to be useful for the study on liver cirrhosis and hepatocellular carcinoma.
Carcinoma, Hepatocellular↗
[Ferritin and malignant tumors].
Explore the source record for details and available documents.
Female↗
The Shwartzman reaction: a review including clinical manifestations and proposal for a univisceral or single organ third type.
The Shwartzman reaction was first described more than 50 years ago and two types, the generalized and the localized, were established in the early 1930s. Studies were mostly related to experimental pathology or immunology, and its significance in clinical medicine was initially obscure though thought to be obstetrically relevant. It is thought that the generalized type has a relation to human disease and that disseminated intravascular coagulation in man is really the counterpart of the generalized Shwartzman reaction in animals. The localized type on the other hand does not have obvious practical clinical pathological significance and tumor necrosis may be the only real example which is commonly seen. Further studies on the Shwartzman reaction relevant to human pathology have, however, suggested that it could be applied to several diseases, the pathogenesis of which was still obscure. The significance seems, however, different from either the generalized or localized type of reaction and so a proposal of the incidence of a third type--'univisceral' or 'single organ' Shwartzman reaction is made. Acute liver necrosis, Waterhouse-Friderichsen's syndrome, haemolytic uraemic anemia, idiopathic pulmonary haemorrhage, acute pancreatitis, acute pituitary necrosis and pseudomembranous colitis all seem to have features suggesting that they could be clinical manifestations of this type of Shwartzman reaction with focal intravascular coagulation.
Adrenal Gland Diseases↗
Victoria blue-nuclear fast red stain for HBs antigen detection in paraffin section.
Hepatitis B surface antigen, in paraffin embedded sections, can be stained by victoria blue and recognized easily against the background, including the cytoplasm and nucleus, stained by nuclear fast red. This new staining method has many merits such as easy staining procedure, long stability of dye solution, negative stainability of ordinary bile pigment, etc., and seems to be quite useful for routine as well as research works in hepatology.
Hepatitis B Surface Antigens↗
Acute hepatic cell necrosis experimentally produced by viral agents in rabbits.
Acute and extensive hepatic cell necrosis was produced experimentally in rabbits by means of the Shwartzman mechanism using adeno- and hepatitis B viruses. The change that occurred in the liver was quite severe, namely, areas of hemorrhagic necrosis of various sizes in gross appearance and lytic-coagulative necrosis with hemorrhage and leukocyte-mononuclear cell infiltration histologically. Thrombi formation was noted in and around the necrotic areas, and it was not unusual to see necrosis of an entire lobe. This seems to be a model, to some extent, for human fulminant hepatitis caused by hepatitis virus infection, and suggested that some nonspecific reaction such as intravascular clotting may also play an important role in causing or complicating acute, severe, and extensive necrosis of the liver in human cases. Heparin administration very effectively prevented such hepatic necrosis, which supports the view that the change we observed in the liver was really the Schwartzman reaction; further, it is reminiscent of the fact that heparin administration is sometimes effective in fulminant hepatitis treatment if given at te appropriate stage of the disease.
Acute Disease↗
[Measurement of ferritin by GammaDab Ferritin RIA Kit (author's transl)].
Explore the source record for details and available documents.
Female↗
Pineal synaptic ribbons in blinded rats.
To study the effects of bilateral ophthalmectomy on the circadian rhythm of the pineal gland, the number of the synaptic ribbons and ribbon fields in the pineal gland of female rats were determined by electron microscopy. In a preliminary experiment, the pineal gland was taken from rats at 15 days, and 1, 2, 3, 4, and 6 months after bilateral ophthalmectomy. It was found that the numbers of both synaptic ribbons and ribbon fields decreased markedly and reached a minimum at 1 month postoperatively, but recovered completely after 4 months. In the main experiment, the number of these intracellular elements was counted in both control and enucleated animals killed at 4 h intervals between 02:00 h and 22:00 h at either 1 month or 6 months after operation. All animals were kept under a lighting regimen of 12 h of illumination (06:00 to 18:00) and 12 h of darkness (18:00 to 06:00). After 1 month, a remarkable decrease in the number of both the synaptic ribbons and ribbon fields was again noted but the circadian rhythm still remained. Complete quantitative and qualitative recovery in the circadian rhythm was obtained 6 months later.
Animals↗
Formation of purple hemocyanin upon addition of ethyleneglycol to Sepioteuthis lessoniana oxyhemocyanin.
We report the formation of purple hemocyanin upon addition of ethyleneglycol to a solution of Sepioteuthis lessoniana oxyhemocyanin in 0.05 M Tris-HCl buffer (pH 7.5). Spectroscopic studies on the purple hemocyanin indicate that this transformation between the normal blue state and the purple state of oxyhemocyanin is essentially a reversible one. The purple hemocyanin exhibits esr signals that correspond to about one-fifth of the total copper obtained. The results suggest that ethyleneglycol causes a moderate and reversible deformation of the active site of the oxyhemocyanin.
Animals↗