Biomedical subjects
Publications and source records attributed to W Mohr.
In calf rib cartilage, about one half of total hyaluronate is soluble with guanidinium hydrochloride, the other half only after collagenase treatment. Evidence is presented for its pericellular and intracellular distribution.
Cartilage destruction in rheumatoid arthritis may be mediated by enzymes of the synovial fluid and by cells of the proliferating pannus tissue. Neutrophilic granulocytes are usually said to affect the cartilage via the synovial fluid, and their local occurrence in the pannus-cartilage border is denied. However, a morphological study on pannus tissue and cartilage by use of histochemistry and immunfluorescence (leucocytes antielastase) exhibited an accumulation of neutrophilic granulocytes in the immediate vicinity of the cartilage in destruction. This result is in contrast to the observation of most investigators reporting studies of the pannus cartilage junction. Experimental datas of the effect of elastase moreover indicate that this enzyme is capable to penetrate into the cartilage and to degrade proteoglycans. Therefore the results show that the occurrence of neutrophilic granulocytes at the pannus-cartilage border is an important phenomenon for understanding the progressive cartilage destruction and that elastase may be at least one enzyme responsible for the degradation of the cartilage matrix.
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The incorporation of 3H-proline into the hyaline articular cartilage of rats with and without adjuvant-induced arthritis was investigated 1 h after the intravenous injection of radioactive proline. In the control animals, silver grains were present predominantly over the chondrocytes at all times; on the 28th day the intensity of labeling was notably reduced. In the animals with adjuvant disease reduced radioactivity was observed in the cartilage of the arthritic joints from the 14th experimental day onwards. At all times, however, silver grains occurred over the chondrocytes, including those in the pannus-covered cartilage and in cartilage sequesters. It is concluded from the investigations that the arthritic process accompanying the development of pannus reduces collagen synthesis and that the pannus tissue ingrows vital cartilage.
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The screws and plates used in operative treatment of fractures cause moments of friction between the bone screw head and the bone plate hole during the tightening of the screws. This results in hidden damage to the grinding metal surfaces, with the danger of erosion corrosion and in a reduction in the screw force. By covering the screw heads with the lubricating sprays PTFE or graphite friction was significantly reduced, the screw force increased by 40% and extensive damage to the surfaces avoided. Lubricating sprays or their extracts, in fetal calf serum or in dimethylsulfoxide, were added to fibroblast cultures. Toxicity was manifest as changes in the synthesis of DNA, as measured by autoradiography. Sprays or spray extracts in fetal calf serum did not inhibit cell proliferation. In vivo experiments in rats reflected the in vitro results, there being no evidence that toxic substances were released from the sprays by physiological solvents: There was a lack of histopathological changes in the inner organs and a local encapsulation of implants which was essentially like that in a teflon control group.
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