Biomedical subjects

W Michels

Publications and source records attributed to W Michels.

66 records · Page 4Linked to original sources

PubMedDate not supplied

[Pharmacokinetics of cefotaxime during late pregnancy].

Examining serum level values and urinary concentrations taken from nonpregnant control persons and pregnant women suffering from urinary tract infections (UTI) during the third trimenon, the pharmacokinetic dates after single application of 1 g cefotaxime have been evaluated. We used a computer program based on the two-compartment model. It is shown that during pregnancy complicated by UTI the elimination half-life will be prolonged, the distribution volumes and clearance values will be increased. The results discussed with the dates given by literature allow us to state that it is not necessary to change dosage and application interval of cefotaxime during pregnancy.

Adult↗

PubMedDate not supplied

[Pharmacokinetic studies of cefotiam in late pregnancy].

Examining blood level values and urinary concentrations taken from pregnant women during the third trimester and nonpregnant female volunteers, the pharmacokinetic dates of cefotiam (a second generation's cephalosporin) have been evaluated. We used a computer program of an open two-compartment model for intravenous injection. We found an increase of some pharmacokinetic parameters (elimination half-life, distribution volume, clearance) during pregnancy. Because the serum levels were yet effective and nearly equal 6 hours after intravenous injection we state that it is not necessary to change the dosage and the application interval of cefotiam during pregnancy.

Adult↗

PubMedDate not supplied

[Methodologic problems and initial results of synchronous CTG computer-assisted registration of fetal movements by ultrasound].

Aim of the studies is the registration of latent criteria of hypoxia in fetuses with intrauterin growth retardation diagnosed by ultrasonography. Under standardized conditions, 19 pregnant women with hypotrophic and 20 with eutrophic fetuses were examined between weeks 36 and 40 of gestation. Concomitantly, fetal body and respiratory movements as well as the antenatal phonocardiotocogram were registered. The following apparatuses were used (fig. 1): ultrasound unit "sono Diagnost R" from Philips, FRG; six-channel recorder "6 NEK 401" from VEB Kombinat Messgerätewerk Zwönitz, GDR; lab-oriented computer "K 1520", VEB Kombinat Robotron Dresden, GDR; fetal monitor "MT 810" (with autocorrelation) from Toitu Co., LTD, Tokyo, Japan; There were close correlations between fetal body movements and accelerations in the cardiogram. The duration of the fetal body movements influenced the duration as well as the amplitude of the corresponding accelerations. A. comparison between the two groups examined reveals that these medium term changes in the heart rate were less marked in the hypotrophic fetuses than in the control group. The differences between the two groups were statistically significant (fig. 2, 3, 4, 5). Fetal respiratory movements influence the range of beat-to-beat-variability in the cardiogram. In the group of hypotrophic fetuses this range increased significantly by 1.4 bpm during one segments of respiratory movement. For the group of eutrophic fetuses the increase in the range of beat-to-beat-variability was 1.8 bpm. We did not find a significant difference between both groups.(ABSTRACT TRUNCATED AT 250 WORDS)

Female↗

PubMedDate not supplied

[Fetal movement and heart acceleration behavior in eutrophic and hypotrophic fetuses in the 36th to 40th week of pregnancy].

By means of combined ultrasonic and cardiographic monitoring, the movement and acceleration behaviours of 44 eutrophic fetuses were compared to those of 19 fetuses with body weights between the 6th and 10th weight percentiles according to Kyank and to 21 fetuses with body weight not greater than the 5th weight percentile. The eutrophic fetuses moved more frequently and--related to 10 minutes examination time--over longer total periods than did the fetuses with intrauterine growth retardation. The longest mean duration of isolated fetal movement, however, was observed in the hypotrophic fetuses. With regard to fetal resting and activity stages, the highest percentage (10%) of fetal resting stages was found in the fetuses less than or equal to the 5th weight percentile. 93% of all accelerations in fetal heart rate obviously resulted from fetal movements, duration and amplitude of the accelerations depending on the duration of fetal movements. The degree of heart rate responses to fetal movements was different in the three groups examined. Standard weight fetuses responded most intensively. The percentage of fetal movements resulting in accelerations was highest (76%) in the group of the eutrophic fetuses as well. The mean duration of acceleration was most marked in the group of fetuses less than or equal to the 5th weight percentile (32.8 sec) and so was the mean acceleration amplitude in the normotrophic fetuses (19.7 bpm). Decelerations following accelerations in fetal heart rate did not differ in the three groups examined with regard to their number, amplitude and duration.

Female↗

PubMedDate not supplied

[Parturient studies of the cardiotocogram score and transcutaneous oxygen pressure in hypotrophic and eutrophic fetuses].

Semiquantitative and quantitative principles of cardiotocogram evaluation are necessary for the evaluation of subacute and chronic oxygen deficiency in fetuses. By means of tcPO2 measurement it is possible to check these evaluation principles for their relation with fetal oxygen pressure. From 59 tcPO2 cardiotocograms, a total of 99 30-minute-intervals were analysed. 27% of the fetuses showed growth retardation (below the tenth weight percentile according to Kyank). Fetal oxygen pressure was statistically significantly (alpha less than 0.05) correlated with changes in the CTG score according to Hammacher. In the group with hypoxemic oxygen pressure (below 11 mmHg/1.47 kPa) the correlation was particularly high, and the CTG score of 5 points was significantly poorer than the 3 points in the nonhypoxemic control group. Our investigations essentially confirm the grading of the CTG score by Hammacher. Hypotrophic fetuses showed a significantly poorer CTG score, and their oxygen pressure of 12.9 mmHg (1.7 kPa) was significantly below that of the control group (15.4 mmHg/2.1 kPa).

Blood Gas Monitoring, Transcutaneous↗

PubMedDate not supplied

[Classification of subpartal fetal heart rate oscillations by tcpO2 measurement].

There is no uniform opinion on the clinical value of FHR variability. It is possible to study connections between FHR variability and fetal oxygen tension by means of tcpO2 measurement. 856 episodes from 64 tcpO2 CTGs with more than 2 300 single characteristics were used for analysis. 31% of the fetuses examined exhibited signs of intrauterine growth retardation. The frequency of variability revealed a statistically significant correlation with oxygen tension (p less than 0,001). In hypotrophic fetuses the amplitude of variability was significantly correlated with oxygen tension (p less than 0,001). Silent and narrowly undulatory oscillations reached the significantly lowest oxygen tension values of 11,8 mmHg (1,6 kPa) and 15,2 mmHg (2,03 kPa), respectively, as compared to 20,5 mmHg (2,73 kPa) and 24,2 mmHg (3,23 kPa) for undulatory and saltatory oscillations, respectively. The control group of eutrophic fetuses revealed an inversely proportional, statistically significant behaviour of the amplitude of variability and fetal oxygen tension (p less than 0,001). Classification by means of tcpO2 limits (less than or equal to 11 mmHg = hypoxemic and greater than or equal to 12 mmHg = non hypoxemic) confirmed the traditional classification of the amplitude of variability in fetal growth retardation.

Female↗

PubMedDate not supplied

[Comparison of transcutaneous oxygen pressure measurement with computer automatic CTG analysis sub partu].

514 labors from 20 tcpO2-cardiotocograms with about 10 000 events were computerized. By means of tcpO2-measurement we found a higher correlation between the fetal condition basing on a discriminant function (DF) than to the quantitative solitary parameters (residual-bradycardia, fetal heart frequency, dip area, lag time and bradycardia-index). The boundary ranges from the quantitative CTG-interpretation: "normal", "praepathological" (warning signs) and "pathological" (hypoxie signs) were confirmed for practice. The tcpO2-curve basing on quantitative analysis of their parameters (base line, slope of pO2 referring to labors and the delay time) is good adapted for examination of solitary CTG-parameters in relation to clinical practice.

Computers↗

PubMedDate not supplied

[Significance of tcPO2 limit values in classification of cardiotocograms].

The continuous transcutaneous measurement of oxygen pressure has got an important method for the improvement of CTG-changes. A quantitative evaluation of the tcPO2-curve allows a better prediction of hypoxemia and acidosis with help of the CTG. Precondition is the examination of bound-values from the tcPO2-parameters: Baseline of oxygen pressure (PB), decrease of oxygen pressure (PD) and its delay time (DL). For this purpose we used 1 027 contraction patterns from 48 tcPO2-CTGs with 12 000 single parameter-values. It seems, that 11-12 mmHg (1,47-1,6 kPa) is a significant bound. CTG-pattern with PB greater than or equal to 15 mmHg (2 kPa) are not connected with hypoxemia and PB-values less than or equal to 10 mmHg (1,33 kPa) show the hypoxemic image of the CTG. The contraction-related decrease of oxygen pressure (PD) and its delay time (DL) are useful for estimation of the importance of variable decelerations. PD less than 2 or 3 mmHg (0,27-0,4 kPa) and DL higher than 46 seconds allow a classification of variable decelerations to the not hypoxemic type. PD equal to or greater than 5 mmHg (0,67 kPa) and DL between 40 and 20 seconds are suspicious for the hypoxemic type. These investigations are the supposition for a computer-aided classification of CTG-pattern with bound-values of the tcPO2-curve.

Female↗

PubMedDate not supplied

[Early and late morbidity of underweight (LBW) newborn infants following breech presentation in relation to the mode of delivery].

The influence of type of delivery on neonatal mortality, frequency of disturbances in adaptation to extrauterine life, and incidence of deviations in psychomotoric development was examined retrospectively in 126 low birthweight infants born in breech presentation. 65 infants were born by cesarean section, 61 by vaginal delivery. The control group involves 270 low birthweight infants born spontaneously in vertex presentation. In the weight categories of 1500 to 2500 g neonatal mortality, frequency of pathologic Apgar-scores, acidosis morbidity, incidence of severe respiratory distress, and percentage of psychomotoric handicaps were found to be lower in infants born by cesarean section compared to vaginally born newborns. However, only some of the differences between both groups were statistically significant. In newborn infants weighing less than 1500 g at birth an improved outcome after abdominal delivery could not be demonstrated.

Acidosis↗

PubMedDate not supplied

[Morbidity of term and low-birth weight infants born in breech presentation by vaginal or abdominal delivery].

182 children born in breech presentation were investigated at the age of 5 to 6 years with regard to late morbidity after vaginal delivery and caesarean section. From case historical data, development in early childhood was assessed comparing the criteria of walking, speaking and "dryness". An attempt was made to find a relation between neonatal data and late morbidity. 156 children (85,7%) had a birthweight of not less than 2 500 g. 26 children (14,3%) were preterm and/or small for date. 80 term babies and 8 preterm and/or small for date babies were delivered by caesarean section. The birth weight of the preterm and/or small for date babies was 2 212,5 +/- 286,5 g for those delivered by caesarean section and 2 070,5 +/- 312,0 g for those delivered vaginally. The investigation program consisted of the following items: A. Assessment of intellectual development by means of the Raven-test, B. Examination of total and minute motor activity by means of the Rostock- Oseretzky -scale, C. Assessment of concentration abilities according to Koch- Pleissner . Statistically significant advantages in all items investigated were found in the group of term as well as preterm and/or small for date babies delivered by caesarean section. Except for intellectual development, analogous results were found for term delivered babies. Concerning development in early childhood, as reflected in walking, speaking and "dryness", there were no statistically significant differences between children delivered vaginally and those delivered by caesarean section. No relation could be found between neonatal data (Apgar-score, pH-value in the umbilical artery) and late morbidity. Problems of birth management are discussed.

Apgar Score↗

PubMedDate not supplied

Effect of 5'-terminated (2'-5')-oligoadenylates on cap degrading activities in rat liver nuclei.

(2'-5')-oligoadenylates bearing a 5'-terminal triphosphate or a 5'GTP-group inhibit the activity of a dinucleoside triphosphatase in rat liver nuclei thereby protecting mRNA against 5'-exonucleolytic degradation. (2'-5')-oligoadenylates, on the other hand, were known to enhance the activity of an endoribonuclease, RNaseF. Thus a synergistic effect may be assumed in vivo, i.e. cellular metabolism seems to be protected twice in virus-infected cells.

Adenine Nucleotides↗

PubMedDate not supplied

[Computerized analysis of intrapartum cardiotocograms].

307 monitored labors were investigated by means of a discrimination function (DF) in relation to qualitative CTG-parameters. In this connection we could confirm on the one hand well defined qualitative CTG-criteria in their clinical importance by computation corresponding to "normal", "prepathological" (warning-signs) and "pathological" (signs of hypoxia). On the other hand we could demonstrate the exactly recognition of qualitative CTG-parameters in attendance of computation. The boundary ranges of discrimination function resulting from the automatic CTG-analysis respecting fetal condition turned out to be reproduced and clinically reliable. The prediction with regard to neonatal parameters (pHNA, APGAR-score 5 minutes after delivery) is justifying the employment of present soft ware in clinical practice.

Acidosis↗