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Biomedical subjects

W Marget

Publications and source records attributed to W Marget.

At least 55 records · Page 3Linked to original sources
PubMed1978

The influence of maternal immunoglobulin-G-antibodies on indirect haemagglutination in newborns.

High antibody titers against Escherichia coli were found in 100 randomly selected pregnant women by means of indirect haemagglutination (IHA). After birth, sera from the umbilical vein of the newborns were also tested. It was found that the indirect haemagglutination titers of the children were strongly influenced by the IgG which had been transferred via the placenta. Twenty-two sera of newborns showed an increased IHA-titer against E. coli, but only seven children displayed specific IgM antibodies, determined by indirect immunofluorescence. After chromatographic separation of the sera into IgG and IgM fractions, it was demonstrated that isolated antibodies of the IgG type alone can produce increased IHA titers. The assumption that the indirect haemagglutination is determined almost exclusively by antibodies of the IgG type is unfounded. Therefore, indirect haemagglutination is not suitable as a screening-test for newborns.

Antibodies, Bacterial↗
PubMed1978

[Recognition of bacterial infections in newborns by measuring specific antibody-titres (author's transl)].

Antibodies were measured in 172 unselected neonates against mixed polyvalent antigens derived from E. COLI, Klebsiella, Ps. aeruginosa and Proteus spp. respectively, using a modification of the indirect haemagglutination technique according to Neter. 120 of these neonates with no evidence of infection served as controls. 6 out of 8 children with proven E. coli septicaemia had either raised titres or significant rises in titre. Five further neonates with septicaemia, four due to Klebsiella and one to Pseudomonas, had pathologically raised titres as well. 8 out of 12 neonates with clinically suspected septicaemia in whom no pathogen was isolated from the blood or cerebrospinal fluid had raised antibody titres. Following premature rupture of the membranes 2 out of 3 neonates who subsequently developed proven E. coli septicaemia had raised antibody titres against E. coli even on the first day of life. These results suggest that the measurement of antibody titres can be a valuable aid to the diagnosis of neonatal septicaemia.

Antibodies, Bacterial↗
PubMed1977

[Evaluation of diagnostic parameters in chronic recurrent urinary tract infections in children. IV. The isotopic renogram (author's transl)].

The results of isotopic renograms (ING) (n = 73) and renal concentration capacity tests (n = 65) performed at the same time before and during therapy of recurrences have been compared. In 43 children with chronic urinary tract infections. ING done prior to chemotherapy showed pathologic findings in 65% of children with bacteriuria. A significant correlation between normal and pathologic findings of ING and renal concentration capacity tests has been found. Impaired (normal) renal concentration capacity lead to pathologic (normal) ING in 74% of cases. 94% of children with a pathologic ING either had bacteriuria children with pyelonephritis (n = 19) the ING was pathologic, whereas in all children with cystitis (n = 8) it was normal. During therapy the ING became normal before the impaired renal concentration capacity returned to normal.

Adolescent↗
PubMed1976

[Course and prognosis of acute bacterial meningitis in infancy in relation to age and individual disposition (author's transl)].

Bacterial meningitis should in principle be easily accessible to chemotherapy. The results of treatment cannot, however, be regarded at all optimistically although in recent years the therapy has brought an improvement in prognosis. Astonishingly, the therapeutic recommendations in common use even today are already 20 years old, so that the more favorable treatment results must be attributed to an earlier and more accurate diagnosis. The neurological damage following survival of meningitis is considerable, in particular, capacity to remember and powers of concentration remain impaired. Examination of these patients before school and observation during their schooldays is therefore essential.

Acute Disease↗
PubMed1976

[Adenosine deaminase deficiency in primary immunodeficiencies (author's transl)].

The occurrence of severe combined immunodeficiency (SCID) with adenosine deaminase (ADA) deficiency in erythrocytes has been reported in 14 patients. Enzyme deficiency may result in early depression of the lymphatic system. ADA is detectable in different tissues by photometric and electrophoretic methods. The gene locus for ADA has been localised on chromosome 20. Studies on the enzyme defect in different forms of primary immunodeficiencies led to the description of a well defined nosological entity. New aspects can be expected in the fields of pathogenesis, prenatal diagnosis, genetic councelling, and possibly therapeutic trials.

Adenosine Deaminase↗
PubMed1976

[Lipid A antibody titers in Crohn's disease (author's transl)].

Lipid A antibody titers and O antibody titers against E. coli were determined in 18 patients with Crohn's disease, 28 patients with ulcerative colitis, 24 patients with acute enteritis and in 68 healthy adults. The patients with Crohn's disease showed a statistically significant elevation of the lipid A antibody titers and of the O antibody titers against E. coli compared with each of the three other groups investigated. The results could be indicative of bacterial involvement in the pathogenesis of Crohn's disease. The determination of lipid A antibody titers may be useful for the differential diagnosis between Crohn's disease and ulcerative colitis.

Adult↗
PubMed1976

[Lipid A antibody titers and O antibody titers in Crohn's disease, ulcerative colitis and acute enteritis (author's transl)].

In 18 patients with Crohn's disease, 28 patients with ulcerative colitis, 24 patients with acute enteritis and in 68 healthy adults lipid A antibody titers were determined by the passive hemolysis test. In addition O antibody titers to polyvalent Escherichia coli, Klebsiella, Proteus and Pseudomonas aeruginosa antigens were measured by indirect hemagglutination. The patients with Crohn's disease showed a statistically significant elevation of the lipid A antibody titers compared with each of the three other groups investigated. The O antibody titers for the four polyvalent antigens were higher in the patients with Crohn's disease than in the other groups. The results indicate that Enterobacteriaceae are involved in the pathogenesis of Crohn's disease. Thus, long-term treatment with wide spectrum antibiotics seems to be justified. The determination of lipid A antibody titers may be useful in differentiating between Crohn's disease and ulcerative colitis on diagnosis.

Antibodies, Bacterial↗
PubMed1976

[Endangering hospital patients to infection by therapeutic measures (author's transl)].

About 5% of all patients fall ill with anosocomial infection, i.e. one acquired in hospital. Among the principal causes of this are therapeutic measures which lead to an increased exposure of patients to organisms (soiled artificial respiration equipment, venous catheters, urinary catheters etc.) and to a raised disposition in the patients due to reduction of endogenous defense (cytostatic therapy, corticoids irradiation, operations etc.). Cross infections are largely transmitted on the hands of doctors and nursing personnel. The detection, prevention and control of hospial infections by specially trained personnel (hospital infection officers, specialist hygiene nurses, hospital hygiene committees) is absolutely necessary and justified for economic reasons alone.

Adult↗
PubMed1976

Is the pathogenesis of Crohn's disease similar to that juvenile recurrent pyelonephritis? A study of lipid A antibody titers in Crohn's disease, ulcerative colitis and acute enteritis.

In 18 patients with Crohn's disease, 28 patients with ulcerative colitis, 24 patients with enteritis and in 68 healthy adults lipid A antibody titers were determined by the passive hemolysis test. In addition, 0 antibody titers to polyvalent E. coli, Klebisella, Proteus, and Ps. aeruginosa antigens were measured by indirect hemagglutination. The patients with Crohn's disease showed a statistically significant elevation of the lipid A antibody titers compared with each of the three other groups investigated. The 0 antibody titers for the four polyvalent antigens were also higher in the patients with Crohn's disease than in the other groups. The results indicate that Enterobacteriaceae are involved in the pathogenesis of Crohn's disease. Thus long-term treatment with wide spectrum antibiotics seems to be justified. The determination of lipid A antibody titers may be a useful diagnostic tool in differentiating between Crohn's disease and ulcerative colitis.

Acute Disease↗
PubMed1976

Use of Amikacin in a hospital for children: microbiological and clinical studies.

Trends in relative susceptibility of clinical isolates, mostly from newborns with nosocomial infections, to the aminoglycosides in use in a hospital for children are described and related to practical therapeutic aspects. Currently, amikacin is the most effective of the available antibiotics against many gram-negative bacterial species, and its administration appears to be as complicated as that of other aminoglycosides. With 5 mug/ml taken as the cut-off point for susceptibility in vitro, 90% of 211 clinical isolates (Pseudomonas aeruginosa, Escherichia coli, Klebsiella, Serratia, and other species) could be considered sensitive to amikacin; the respective figures for sensitivity to sisomicin, gentamicin, and tobramycin were 80.5%, 66%, and 70%. Cross-resistance of microorganisms to amikacin and gentamicin, sisomicin, or tobramycin has not been demonstrated. Treatment with amikacin was successful in 13 of 15 children (premature and normal newborns with primarily septicemia); death of two patients was attributable to the underlying disease. For neonatal infections we recommend 12 mg of amikacin/kg per day; determination of the minimal inhibitory concentration for the causative pathogen and monitoring of serum concentrations are desirable.

Amikacin↗