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Biomedical subjects

W Mann

Publications and source records attributed to W Mann.

At least 235 records · Page 13Linked to original sources
PubMed1979

[Effect of temperature on RNA synthesis in Escherichia coli CRT 266 (dna Bts) following infection with bacteriophage T3].

Infection of the temperature-sensitive E. coli CRT 266 (dnaBts) with T3-phages at the temperature of 30 degrees C and 35 degrees C, respectively, induced T3-specific RNA synthesis with a maximum rate at 7 min (30 degrees C) and 4.5 min (35 degrees C) after infection. At temperatures above 40 degrees C no T3-induced RNA synthesis could be observed. Infection of E. coli CR 34--45 (dnaB+) with T3 phages at 30 degrees C, 35 degrees C and at temperatures above 40 degrees C, however, produced T3-specific RNA synthesis. The maximum of T3-induced RNA synthesis could be observed between 7 min and 3 min depending on the temperature during infection. The inability to form T3-specific RNA after infection of E. coli CRT 266 at nonpermissive temperatures may be a cause for the absence of the formation of T3 phages and lysis of the host cells.

Chloramphenicol↗
PubMed1978

[How effective is the inferior meatal antrostomy in chronic maxillary sinusitis? (author's transl)].

44 inferior meatal antrostomies in 32 patients have been followed over a period of 2 years. Control of the results by means of sinuscopy, ultrasonography, x-ray's, biopsies and subjective as well as objective findings revealed good results in 89% of the patients. Closure of the fenestration occurred in 29,5% but had no bearing on the recurrency rate of sinusitis. Improvement was noticeable even after closure. Allergy did not play an important role. Mucociliary transport was evident through the window, permitting adequate ventilation and drainage.

Follow-Up Studies↗
PubMed1978

Bloody pericardial fluid. The value of blood gas measurements.

Clinically notable pericardial effusions developed in three patients with renal failure. Pericardiocentesis showed hemorrhagic fluid, the source of which was not apparent. Simultaneous determinations of PCO2, PO2, and pH values showed a substantial increase in PCO2 levels and decrease in PO2, pH, and bicarbonate levels in the pericardial compared with the intracardial aspirates. This was true when pericardial fluid PCO2, PO2, and pH values were compared with mixed venous samples. Determination of PO2, PCO2, pH, and bicarbonate values in pericardial aspirates may determine the source of the fluid.

Bicarbonates↗
PubMed1978

Relationship between tubal function, craniofacial morphology and disorder of deglutition.

26 children without hearing impairment have been examined by otolaryngologists and orthodontists. According to the tubal function test in a pressure chamber they were classifed into a group with good and poor tubal function. The E.N.T. examination was unconclusive for a possible relationship between rhinological findings, mode of breathing, sinusitis, size of tonsils, nasal airway resistance and tubal function. Adenoids proved to be a mechanical impairment for active tubal function as stated by many authors. The cephalometric analysis of lateral head films combined with a static and dynamic-functional evaluation of tongue posture revealed significant differences between children with good and poor tubal function. Subjects with a vertical craniofacial growth pattern seem to be predisposed for poor tubal function. Analysing static tongue posture in children with poor tubal function the tongue lies more retracted in a backward position. The back of the tongue is flattened in relation to the palatal arch. In children with good tubal function there is a much closer contact between the back of tongue and the hard palate. Subjects with poor tubal function have an increased incidence of abnormal deglutition combined with tongue-thrust, teeth-apart swallowing, lack of sealing off the anterior oral cavity and contraction of the circumoral musculature. In children with good tubal function one can find the somatic type of swallowing that means no contractions of the circumoral muscles, no tongue-thrust during deglutition but contact of the molars and contraction of the masseter muscle.

Airway Resistance↗
PubMed1978

Effect of timolol plus hydrochlorothiazide plus hydralazine on essential hypertension.

The effect on hypertension of hydrochlorothiazide 100 mg daily plus timolol 20-60 mg daily versus hydrochlorothiazide plus placebo and of hydrochlorothiazide plus timolol plus hydralazine 40-200 mg daily versus hydrochlorothiazide plus placebo plus hydralazine was evaluated in a double-blind, randomized, crossover study in 38 patients with hypertension. Hydrochlorothiazide plus timolol was more effective than hydrochlorothiazide plus placebo in lowering both supine and standing systolic and diastolic blood pressures. Hydrochlorothiazide plus timolol plus hydralazine was a very effective regimen in lowering both supine and standing systolic and diastolic blood pressure. The patients tolerated this regimen well with greater hypotensive activity and a lower incidence of side effects than on hydrochlorothiazide plus placebo plus hydralazine.

Adult↗
PubMed1978

[Effect of temperature on formation of lysozyme in E. coli CRT 266 (dnaB ts) after infection with bacteriophage T3].

Lysozyme formation induced by bacteriophage T3 was studied in the ts-mutant E. coli CRT 266 (dnaBts) and in the wild-type E. coli CR 34--45 (dnaB+) at different temperatures. It was found that lysozyme was formed in E. coli CRT 266, however, no lysozyme synthesis took place at 41.5 degrees C. These results indicate that the expression of the lysozyme gene is disturbed in the ts-mutant at 41.5 degrees C.

Coliphages↗
PubMed1978

[Presbycusis (author's transl)].

This study is base on 438 patients (age 45-99), 250 women and 188 men, divided into decades from 45 to 95 years. Mean hearing levels were measured at 63 up to 12000 Hz using the atlas pure-tone audiometer. Statistical analyses helped estimating the influence of various anamnestic datas on sensorineural hearing loss. 65 patients with diabetes had no hearing loss related to their disease. In 115 noise-exposed patients 'correction for noise' was 5 to 7 dB at 2000 and 4000 Hz. There was no difference in men and women at any frequency and any age group. 'Average presbycusis' in the literature today is too positive. Starting age 20, a linear progressive hearing loss for all frequencies ranging from 6 to 18 dB per decade can be detected, being less for the lower than for the higher frequencies.

Adult↗
PubMed1978

[Measurement of sinus secretions viscosity (author's transl)].

Viscosity studies of the paranasal sinus secretions reflect the recovery of the damaged secretory mucosa. Effectful treatment leads to an increase associated with a wider range between maximal and minimal viscosity. The type of microorganism is less important.

Humans↗
PubMed1978

[Surgical or conservative treatment in orbital complications of sinus inflammations (author's transl)].

47 patients with orbital complications resulting from acute sinusitis have been treated at the Freiburg ENT Department during the last seven years. Acute ethmoiditis predominated in children, while pansinusitis was more common in adults. Previous sinus surgery did not prevent orbital complications arising from the same sinus. Orbital involvement was classified into periostitis, subperiosteal abscess and orbital cellulitis. According to clinical findings, 44.7% of the patients were managed conservatively. Prognosis was best in periostitis, whereas consersative treatment was unsafe in orbital cellulits. Children usually respond well to appropriate antibiotic coverage but the occurrence of common upper respiratory or anaerobic pathogens should be kept in mind.

Adult↗
PubMed1978

[How good is the inferior meatal antrostomy in chronic maxillary sinusitis? (author's transl)].

44 inferior meatal antrostomies in 32 patients with chronic maxillary sinusitis were followed at two month intervals over a period of two years. Closure of the antrostomy occurred in 29.4% of the cases reported. Allergy was unimportant for the operative result, nor was an increased frequency of infections demonstrated following surgery. Subsequently, improvement of sinusitis was noticable, even after closure of the fenestration. In contrast to other reports in the literature, mucociliary drainage from the maxillary sinus to the nose occurs through the operatively placed fenestra.

Adult↗
PubMed1977

Liability of ultrasound in maxillary sinus disease.

For the first time liability of of ultrasonography in diagnosing paranasal sinus disease was controlled in 256 patients with acute maxillary sinusitis as compared to irrigation findings and in 150 patients with persistent maxillary sinus disease using x-rays, sinoscopy and sinumanometry as controls. Confidence in diagnosing the presence of discharge ranges up 90%. In cases of total opacity of the sinus, ultrasonography helps differentiating mucosal swelling, tumor and discharge.

Acute Disease↗
PubMed1977

[Effect of temperature on the transcription of T3 DNA b y T3-specific RNA polymerase in cell-free extracts of Escherichia coli CRT266].

Cell free extracts were prepared from E. coli CRT266 9 min after infection with T3 phages. RNA synthesis in these extracts is almost entirely due to T3 RNA polymerase. The inactivation of T3 RNA polymerase in these extracts proceeds rapidly at 42 degrees C. 90% of the activity is lost within 10 min at this temperature. Under conditions where the formation of a stable initiation complex with T3 DNA is possible, i.e., in the presence of GPT, APT, and UTP the T3 RNA polymerase becomes protected against heat inactivation losing only )0% of its activity during an exposure to 42 degrees C for 10 min. Studies on the time course of RNA synthesis have shown that reinitiation is still possible at 37 degrees C and 42 degrees C. At 44 degrees C, however, RNA synthesis stops abruptly after 3 min indicating that reinitiation does no longer take place. The elongation of already initiated T3 RNA chains is rather resistant to heat. At 44 degrees C the same elongation rates are observed as at 37 degrees C and 42 degrees C, respectively.

Cell-Free System↗
PubMed1977

Electrosurgical skin incision.

A controlled clinical study shows that there is little difference between skin incisions made with a scalpel or by electrosurgical instruments.

Adolescent↗