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Biomedical subjects

W Lutzeyer

Publications and source records attributed to W Lutzeyer.

At least 37 records · Page 2Linked to original sources
PubMed1983

Quantitative analysis of glycosaminoglycans in urothelium and bladder wall of calf.

Glycosaminoglycans (GAG) were described by histochemical staining procedures in the normal urothelium of the urinary bladder; they are supposed to be involved in the antibacterial defense mechanism. Our quantitative analysis, however, demonstrated only heparan sulfate in the normal calf urothelium (less than 600 nmol/Gm d.wt.); only trace amounts of other GAG were to be analyzed. High concentrations of GAG were found in the submucosa and muscle layers as to be expected in mesoderm originating tissues. According to these results there were no GAG with the exception of heparan sulfate at the surface of the normal urothelium; therefore, glycoproteins detected in mumol/Gm d.wt. ranges are more likely to be involved in the antibacterial defense mechanism.

Animals↗
PubMed1982

[Wound infection and its treatment: urology].

The following aspects are important for prophylaxis and treatment of wound infections in the genitourinary system: wound infections are classified as clean, clean-contaminated, and contaminated-soiled. This classification is elucidated by clinical examples. A closed drainage system, well-controlled diversion of urine, and a sterile surgical dressing are principal points of prophylaxis. Systemic chemotherapy should not be given as a matter of routine. An infected wound must be treated following well-known surgical rules and needs adequate systemic chemotherapy. In an infected urinary tract a short pre-, per-, and postoperative antibiotic treatment is advisable. Under control of urine diversion and drainage, wound dressing should be done with antiseptic but not antibiotic solutions. Irrigations of the genitourinary system are ineffective. An adequate systemic chemotherapy is indicated only if there is danger to life by progression of infection.

Drainage↗
PubMed1982

Prognostic parameters in superficial bladder cancer: an analysis of 315 cases.

A retrospective study of 315 patients with superficial transitional cell carcinoma (stages Ta to T2) and an adequate followup of 3 years or longer is reported. Transurethral resection was done in 80 per cent of the patients and open excision or resection was done in 20 per cent for cure or control. We herein demonstrate that, in addition to grade and stage, multifocal tumor growth and whether the tumor is primary or recurrent influence the frequency of recurrences and tumor progression. The over-all recurrence rate after resection of stages Ta, T1 and T2 tumors within 3 years was 60 per cent. Recurrences after a primary tumor were noted in 45 per cent of the patients and were followed by a second recurrence in 84 per cent, with solitary tumors occurring in 46 and multifocal tumors in 73 per cent. Tumor progression was observed in 24 per cent of patients with solitary tumors, 44 per cent of those with multifocal tumors, 20 to 25 per cent of those with primary and recurrent stage Ta and primary stage T1 tumors, and 56 per cent of those with recurrent stage T1 tumors. Therefore, when therapy is planned stage, grade, multifocal tumor growth and whether the tumor is primary or recurrent should be considered. Stage Ta tumors can be treated sufficiently by transurethral resection even in the case of several recurrences. More aggressive therapy should be considered when multifocal or recurrent stage T1 or T2 tumors recur as invasive carcinomas.

Carcinoma, Transitional Cell↗
PubMed1982

[Value of screening for early detection of urological tumors (author's transl)].

Screening for early cancer detection is of value if (i) appropriate tests are available, (ii) the detected tumor can be treated, and (iii) the treatment improves the quality of life or the mortality rate of the patients. It is demonstrated whether carcinomas of the prostate and urinary tract, renal cell carcinoma, penile carcinoma and testicular tumors satisfy these conditions. Screening for early cancer detection may be indicated in prostatic and urinary tract carcinomas. The clinical examination should include the male genitalia. The indication for sonography of the kidneys to detect renal cell carcinomas is investigated at the moment. Instruction to perform self-examination of the testes should be given to all males older than 20 years.

Adenocarcinoma↗
PubMed1982

Pacemaker process of ureteral peristalsis in multicalyceal kidneys.

The mechanical activity of isolated strips from different areas of the pyeloureteral system was investigated in 10 pigs: calyx, renal pelvis, pyeloureteral junction and ureter. Additionally, electrical activity was measured in some pyeloureteral preparations using the sucrose-gap technique. Regular spontaneous activity with an average frequency of 9.5/min was recorded in calyceal strips, decreasing to 5.4/min in renal pelvis, 5.7/min in pyeloureteral preparations and to 1.2/min in ureteral preparations. The activity of renal pelvis, pyeloureteral and ureteral preparations was less regular, and bursts of fast activity (near 10/min) could be observed in all these preparations. The membrane potential of pyeloureteral strips showed spontaneous generator oscillations of about 10/min. Variations in the pattern of ureteral peristalsis are due to different coupling ratios of membrane potential oscillations to contractions. Adrenaline (10(-5) mol/l) increased the frequency of the oscillations and enhanced their manifestation in the mechanical recordings, whereas tetraethylammonium (5-20 mmol/l) only increased the coupling ratio. The following concept for the generation of ureteral peristalsis in multicalyceal kidneys is developed: several (primary) oscillators exist in the calyces; in the pyeloureteral junction a (secondary) pacemaker exists which has an intrinsic frequency similar to that of the calyceal pacemakers; both processes cooperate in the generation of ureteral peristalsis.

Animals↗
PubMed1982

Intravesical single and combination therapy in superficial bladder cancer. An experimental study.

In this animal experiment it was investigated if intravesical combination therapy is superior to single drug therapy to reduce the growth of N-butyl-N(4-hydroxybutyl)-nitrosamine (BBN)-induced bladder carcinomas in the rat. The evaluation of the histological data gave the following results: intravesical instillation of cytostatic drugs in concentrations similar to that used in man reduce the growth of BBN-induced tumors. The effectiveness of mitomycin C or adriamycin alone is similar to that of alternative administration of mitomycin C and adriamycin.

Animals↗
PubMed1982

[Topical chemoprophylaxis with adriamycin for superficial bladder carcinoma. Clinical and experimental aspects (author's transl)].

Topical instillation of adriamycin for treatment of superficial bladder carcinomas is of little value (complete response less than 40%) in comparison to transurethral resection. Instillation therapy may be indicated in carcinoma in situ (objective response about 70%). Value of topical chemoprophylaxis is not proven in prospective randomized clinical studies up to now. Chemical cystitis is described as local side effect in about 40%, systemic side effects are not expected. Effectiveness of instillation therapy in BBN-induced tumors in the rat can be shown 2 and 8 weeks but not 5 month after the last instillation. Instillation therapy leeds to severe dysplasia and epithelial proliferation in the normal rat mucosa. Up to now topical instillation therapy with adriamycin is indicated in carcinoma in situ (therapeutic) and in multiple, recurrent or poorly differentiated T1 carcinomas (prophylactic).

Administration, Topical↗
PubMed1981

[Clinical analysis of the indication for lymphangiography in urological tumor patients (author's transl)].

TNM classification of urological tumors was reviewed by the UICC in 1978 and should remain unchanged for ten years. Nevertheless the minimum requirements concerning the N-category may be discussed, especially since German urologist did not contribute to the draft of 1978. Lymphangiography should not be included in the minimum requirements to classify renal cell carcinomas, because therapy planning does not depend on regional lymph node metastases, and juxtaregional lymph nodes can not be visualized in general. In bladder- and prostatic carcinomas the staging operation should be included in the minimum requirements; metastases proven by histology should be marked within the TNM system. The minimum requirements should include computed tomography, ultrasound and lymphography. Biopsy, staging operation and lymphography should be considered in case of penile carcinoma.

Adenocarcinoma↗
PubMed1981

[Frequency of recurrences and tumor progression on superficial bladder carcinoma (author's transl)].

A retrospective study with an adequate follow-up of three years or longer of 315 superficial transitional cell carcinomas (Ta--T2) is reported. Patients had transurethral resection in 80% and open excision or resection in 20% for cure or control. It is demonstrated, that in addition to the grade and the stage of the tumor, multifocal tumor growth and whether it is a primary or recurrent tumor influence the frequency of recurrences and the tumor progression. The overall percentage of recurrences after resection of Ta, T1 and T2 tumors within three years is 60%. A primary tumor recurs in 45%, the first recurrence in 84%, solitary tumors in 46% and multifocal tumors in 73%. Tumor progression is observed in solitary tumors in 24%, in multifocal tumors in 44%, in primary and recurrent Ta and primary T1 tumors in 20 to 25%, in recurrent T1 tumors in 56%. Therefore, when planning therapy, stage, grade, multifocal tumor growth and whether it is a primary or recurrent tumor should be considered. Ta tumors can be treated sufficiently by transurethral resection, even in case of several recurrences; more aggressive therapy should be considered, when multifocal or recurrent T1 or T2 tumors recur again as invasive carcinomas.

Carcinoma, Transitional Cell↗