Detecting changes that precede the overt symptoms of cancer and identifying measurable indices of such changes in persons exposed to occupational and environmental carcinogens constitutes one of the primary objectives of molecular epidemiology research. Biomarkers represent a valuable research tool that makes it possible to attain that objective. Suitably selected biomarker sets may provide information on the extent of exposure to carcinogenic agents (internal dose, biologically effective dose), detect early changes caused by those agents in the exposed organism, and identify individuals with a particularly high risk of cancer development. The tremendous progress in research on the mechanisms of cancer initiation and promotion has enabled the assessment of cancer risk in healthy individuals by examining specific results from determinations of suitably selected biomarkers. The finding that gene defects (gene mutations and changes of their expression) constitute the background of carcinogenesis has resulted in molecular biology becoming focused on detecting defective genes or proteins synthesized under control of the defective genes.

Biomarkers↗

PubMedDate not supplied

[Evaluation of phenazone oxidation rate in patients with cancer of the urinary tract].

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Aged↗

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[Lipid metabolism disorders in patients with chronic kidney failure].

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Arteriosclerosis↗

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[Tumor markers and their value in the prevention of occupational cancer].

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Antigens, Tumor-Associated, Carbohydrate↗

PubMedDate not supplied

[Phenotype of xenobiotic oxidation as a marker of sensitivity to respiratory tumors].

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Humans↗

PubMedDate not supplied

[Usefulness of determination of porphyrins and their precursors for the evaluation of disorders of heme synthesis in the liver after exposure to xenobiotics].

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Chemical and Drug Induced Liver Injury↗

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Changes in the molecular spectrum of dextran 40,000 in the blood serum of patients after bilateral nephrectomy and in healthy subjects.

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Adult↗

PubMedDate not supplied

Combined treatment with hemoperfusion and hemodialysis in patients with chronic uremia.

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Hemoperfusion↗

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Lipid composition of gastric jiuce in healthy men under conditions of maximum secretion following pentagastrin stimulation and during an intensified histamine test.

Lipid composition of gastric juice in healthy men under conditions of maximum secretion following pentagastrin stimulation and during an intensified histamine test. Acta Physiol. Pol., 1977, 28 (6): 511-514. The authors studied the changes in lipid concentration of gastric juice under conditions of basic secretion (15 subjects), maximum secretion after pentagastrin stimulation (12 subjects) and during intensified histamine test (15 subjects). It was found that gastric juice contains similar lipid components to the blood plasma, however, their concentrations significantly lower. After histamine stimulation and even more after pentagastrin stimulation, concentration of some lipid fractions increases. The increase in glyceride and cholesterol ester concentrations in the gastric juice under conditions of maximum secretion may be due to the increase of lipid components originating from the blood plasma.

Adult↗