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Biomedical subjects

W Lierse

Publications and source records attributed to W Lierse.

At least 109 records · Page 6Linked to original sources
PubMed1975

[Vulnerability of early postnatal differention processes of the retina and the teratogenic effect of cyclophosphamide (Endoxan)].

During the postnatal period, cyclophosphamide produces in the retina of rats and mice rosettes containing malformed photoreceptor cells arranged in half-circle formations. The rosettes form only after injections given during the first 4 days post partum and only in the receptor layer which contains desmosomes. After this period, the retina becomes resistant to rosette formation. Cytological changes occur in the form of intense nuclear invaginations and membrane whorls, which may be regarded as compensatory processes.

Age Factors↗
PubMed1975

[Postnatal growth inhibition in the rat retina after actinomycin D adminstration].

The effects of actinomycin D on the development of the rats retina were observed. At the day of birth the inner neurons and the inner cells of the bipolar layer are vulnerable. The pale degeneration of these neurons accompanied by a dilatation of the endoplasmatic reticulum and the dark degeneration accompanied by a pycnosis and a shrinkage of the cytoplasm persist during the first 11 days after birth. The same alterations are to be seen in bipolar cells on day 11 after birth. The transient disorganisation of the inner layers could effect the ramification because the stratum reticulare internum is smaller as in untreated animals.

Animals↗
PubMed1975

[The postnatal reaction of the albino rat pigment epithelium after administration of chloroquindiphosphate].

The development of pigment granules has been studied in 0...5 day old normal albino-rats and after a single injection of chloroquinediphosphat. During the postnatal time the pigment epithelial cell changes structurally. The basal region of the epithelium containes lipoidvacuoles and later on glycogen. The apical region form long skin projections that enclose the developing inner segments of photoreceptor cells. The pigment granules develop normally until the stage of melanin deposition. The lamellated premelanosomes are equipped by helical structures. The development of premelanosomes are not disturbed, by chloroquinediphosphate blocking the protein synthesis in the cell. The drug produce lamellated vacuoles inside the cell arising from the ergastoplasm. Also the extracellular space is enlarged. A significant increase or decrease in the number of phagosomes in the pigment epithelial cells after administration of the drug does not occur as compared to the cells of untreated animals.

Albinism↗
PubMed1975

[Ultrastructural reaction of the multipotential glia in the cerebellum of the rat after treatment with 6-aminonicotinamide].

6-Aminonicotinamide (6-AN), an antimetabolite of nicotinamide, damages the astrocytes and oligodendrocytes through a blockade of the pentose phosphate pathway. Both types of glia cells become hydropic. A third type of glia cell, described by VAUGHN and PETERS, the multipotential glia, is affected to a lesser extent. These cells phagocytize and form pseudopodia after treatment with 6-AN. Thus the multipotential glia cells are 'marked' by the action of 6-AN, since they are obviously less dependent on the pentose phosphate pathway in the carbohydrate metabolism.

6-Aminonicotinamide↗