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Biomedical subjects

W Lehmann

Publications and source records attributed to W Lehmann.

At least 145 records · Page 8Linked to original sources
PubMed1979

A rare electrophoretic enzyme variant of serum alkaline phosphatase in a group of Icelanders.

An electrophoretic isoenzyme variant of serum alkaline phosphatase was found in 10 out of 343 subjects belonging to an Icelandic population in Husavik and the Husavik region. 9 of the variant-positive subjects were women. The enzyme variant differs from normal isoenzymes in electrophoretic mobility, substrate specificity, and response to inhibitors. It could be demonstrated that nine of the subjects with the enzyme variant were related with each other.

Adult↗
PubMed1979

[Filling of the Circle of Willis in carotid angiography using halothane anesthesia].

A comparative study of 150 carotid angiographies carried out under local anaesthesia and the same number under halothane anaesthesia did not show any great deviation from the well-known filling rates of the counter-lateral carotid region and the ipsilateral A. cerebri posterior nor any striking differences in the two methods of anaesthesia which could convince of a favourable influence of halothane on the demonstration of the vessels. The causative factors of the filling of adjacent vascularisation regions can certainly only be explained from the complex co-action of physiological and any external factors in cerebral angiography.

Adolescent↗
PubMed1978

[Lymphatic metastasis of the neck. Pluridisciplinary approach--surgery].

The main features of tumoral pathology in the neck are metastatic lymph nodes of carcinomas having their origin in the upper respiratory and digestive tracts. Their prognosis will depend directly on the diagnostic approach and correct treatment. The place and modalities of surgery in the treatment of head and neck metastatic lymph nodes are discussed.

Biopsy↗
PubMed1978

[Kinetics of citric acid production in Candida lipolytica].

The kinetics of citrate and isocitrate accumulation by Candida lipolytica has been studied, with special emphasis of the carbon sources glucose and n-alkanes and the shifts from one carbon source to the other. The accumulation of the citric acids starts with the beginning of ideophase. Trophophase and ideophase behaviour is in parts different. Ideophase behaviour may be influenced by exogenic factors during growth. From the course of the curves for the citric acids two phases can be distinguished: The specific production rate of the first phase is higher than in the second phase (pi1 approximately 0.19 h-1; pi2 approximately 0.14 h-1). The influence of the carbon source on the course of the curves and the numeric value for the specific production rate is negligible. Alcane grown cells accumulate citric acids from added glucose and left-over n-alcanes simultaneously. When both substrates are added from the beginning only glucose is taken up for growth, for citric acid production both substances are utilized simultaneously. Glucose grown cells do not utilize alcanes for production of citric acids. Citric acids are accumulated only as long as glucose is available. Alcane uptake starts after addition of a nitrogen source.

Aerobiosis↗
PubMed1978

The effect of oxazepam on sleep in normal human volunteers.

The effects of 25 mg of oxazepam, a benzodiazepine with a short half-life and no active metabolites, were compared with placebo in two healthy volunteers in a single-blind polygraphically recorded sleep study. The experiment lasted for 24 nights and recordings were made for 11 nights. It was found that 25 mg oxazepam induced sleep faster than placebo, and that the subjects awoke less often during the treatment period. The total amount of REM-sleep was not affected. However, REM-sleep was shortened during the first part of the night and extended during the latter part of the night. Slow-wave sleep diminished differently in the two subjects, possibly due to interindividual differences in the rate of elimination of oxazepam. The effect on blood pressure was small, and the normal physiological difference between bedtime and morning blood pressure was preserved.

Adult↗
PubMed1978

[On secondary operations following submucous septum resection (author's transl)].

The submucous resection of septum by Killian is not appropriate as a primary correcting treatment, especially in case of traumatical septum deformities. Due do the loss of cartilage often form and function of the nose deteriorates in a typical way. These complaints demand an operative correction under complicated circumstances. Based on the patient clietele of the Univ.-HNO-Klinik Erlangen it is demonstrated how secondary operations with the special technique of displacement of the remaining cartilage a satisfying result finally can be achieved.

Congenital Abnormalities↗
PubMed1977

Raman spectroscopic investigation of the interaction of gramicidin A with dipalmitoyl phosphatidylcholine liposomes.

The interaction of gramicidin A with dipalmitoyl phosphatidylcholine liposomes is investigated by Laser-Raman spectroscopy. As revealed by the methylene C-H stretching mode the phase transition of the hydrocarbon chains near 40 degree C is eliminated in the presence of gramicidin A. Liposomes prepared from a mixture of lecithin and cholesterol seem to be unaffected by gramicidin A and show only the normal broadened phase transition.

Binding Sites↗
PubMed1977

Chalone-like inhibition of Ehrlich ascites cell proliferation in vitro by an ultrafiltrate obtained from the ascitic fluid.

An aqueous ultrafiltrate (10 000-50 000 dalton) prepared from the cell-free ascitic fluid of mice bearing Ehrlich ascites tumour (EAT) in the plateau phase of growth (12-16 days after transplantation) was investigated with regard to its inhibitory effects on the proliferation of EAT cells in a 24-hr suspension culture. The following results were obtained: (1) The in vitro proliferation of cells obtained from the plateau phase of in vivo growth was reversibly inhibited. (2) The dose-response curves show a plateau with a maximum inhibition of about 50%, which suggests that not all cells can be affected. (3) Young cells (4-6 days after transplantation) were not inhibited. (4) Preincubation of plateau phase cells in the culture medium before treatment abolishes the inhibitory effect of the ultrafiltrate. This effect of preincubation is dependent on time and serum concentration. It provides the possibility to differentiate between true "chalone-like" and cytotoxic effects. (5) the inhibitory properties of the ultrafiltrate are destroyed by heating or trypsin treatment. (6) Extracts prepared in the same way from ascitic fluid of mice bearing lymphocytic leukemia L1210 do not inhibit the proliferation of EAT cells. Corresponding extracts from ascitic fluid of mice bearing myelocytic leukemia YM were found to be inhibitory; however, the inhibitory effect was also found on preincubated cells and is therefore considered to be due to an unspecific cytotoxicity. In conclusion, evidence was obtained for a factor from the ascitic fluid of mice bearing EAT, which prevents EAT cells from entering the proliferating state.

Animals↗
PubMed1976

A clinical study on the ototoxic effects of tobramycin.

In a clinical, prospective, non-randomized study, tobramycin has shown its high antibacterial activity in Gram-negative bacillary infections. The incidence of ototoxic side effects was very low: none of 18 patients studied before, at the end and 9 months after completion of tobramycin therapy showed any change in pure tone audiograms. Five of these 18 patients had renal impairment: 3 of them developed subjective and objective evidence of vestibular dysfunction, as demonstrated by caloric vestibulometry. However, these bilateral vestibular lesions all proved to be reversible a few weeks after cessation of therapy. Despite the low incidence and the reversibility of the ototoxic side effects, it seems advisable to monitor patients on long-duration tobramycin therapy for signs of vestibular dysfunction, particularly in cases of renal insufficiency.

Aged↗
PubMed1976

[Treatment of disseminated oro-pharyngo-laryngeal epidermoid carcinomas with a combination of methotrexate and bleomycine in small doses].

In the previously published series of patients with generalized head and neck epidermoid carcinoma, a high dose combination of methotrexate (MTX) (0.4 mg/kg biw. i.v.) and bleomycin (BLM) (30 mg biw. iv) produced an objective remission rate of 60% with a median duration of 9 weeks. The disappointingly short duration of the remissions was tentatively related to the short period of treatment, which was limited to 5 weeks in order to keep the cumulative dosage of BLM below 300 mg. In the present study, covering 26 patients, a lower weekly dose was adopted (BLM 15 mg, MTX 0.6 mg/kg). 13 partial remissions were obtained with a median duration of 26 weeks; in 7 cases there was no evolution, in 6 cases progression of the tumor was registered, and there was one death from hematological toxicity. The major toxicity was leuko- and thrombopenia with one toxic death. Digestive and cutaneous side effects and fever were minor. There were 2 cases of major pulmonary toxicity, one of which was lethal. In conclusion, a combination of MTX and BLM at a relatively low dosage is active in disseminated head and neck carcinoma and appears to be compatible with longer maintenance of palliation in comparison with results obtained at a high dose level.

Bleomycin↗
PubMed1976

[Rhinoscleroma with sinuso-orbitary invasion].

The authors present the case of an 11-year-old child with a slowly progressive tumoral invasion resulting in bilateral nasal obstruction, massive facial deformation, and an exophthalmos of the left eye. There was no impairment of the child's general health. The histological investigation revealed the presence of Mikulicz' cells and von Frisch's bacilli. The resultant diagnosis was rhinoscleroma.

Child↗
PubMed1976

[Cervico-facial lesions caused by windshields of tempered glass].

The authors stress the dangers presented by windshield fragments of tempered glass to soft parts of the cervicofacial region, in cases of traffic accidents. With the aid of seven recent clinical observations, the difficulties in emergency surgical treatment, late complications due to the persistence of foreign bodies, and permanent facial mutilations are successively discussed.

Accidents, Traffic↗