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Biomedical subjects

W Lange

Publications and source records attributed to W Lange.

At least 217 records · Page 12Linked to original sources
PubMed1976

[Influence of electronic monitoring of the fetus on the frequency of surgery and on the status of the newborn infant].

In the years from 1971 to 1974 the rate of fetal monitoring of high risk deliveries rose from 3.0% to 23.7%. In this time our clinic become a center of high risk pregnancies (reproductive failure and prematurity). By this way we could not show a decrease of the perinatal and intranatal mortality. The increase of caesarean sections from 3.0% (1968) to 6.0% (1974) was caused by the increasing of high risk patients. Fetal monitoring is not a cause for rising of operative frequency. By means of fetal monitoring the Apgar score of the newborns from mothers with severe diseases is not significant worse than from newborns of mothers with more easy diseases.

Apgar Score↗
PubMed1975

[Demonstration of hepatitis B (surface) antigen. A comparison of different serological methods (author's transl)].

Four third generation tests for the demonstration of hepatitis B (surface) antigen were assessed (Hepamosticon test from Organon-Teknika, Auscell test, Ausria I 125 test and Ausria II 125 test from Abbott) and the results compared with those of immunodiffusion and counter-current electrophoresis (1st and 2nd generation). The results show that the Ausria II 125 test comes very close to the ideal of an optimal test for demonstrating hepatitis B (surface) antigen (HBs antigen). It is clearly superior to both other tests from Abbott and in particular to the Hepanosticon test and the tests of the 1st and 2nd generation. The Ausria I 125 test can be considered as a precursor of the Ausria II 125 test and is less satisfactory as regards sensitivity and practicability and approximately equally good as regards specificity. It should not be considered in the choice of a sensitive test for demonstrating HBs antigen as it has been replaced by the Ausria II 125 test. The Auscell test resembles the Ausria I 125 test as regards sensitivity, its specificity is considerably lower. There are also definite disadvantages in the practicability. The Hepanosticon test is considerably less sensitive than the three tests from Abbott while it is easy to carry out. Its specificity is worse than that of radio-immunoassay and better than that of the Auscell test. In any case it is necessary to test the specificity in all passive haemagglutination tests. Due to poor sensitivity use of both tests of 1st and 2nd generations must be discouraged.

Electrophoresis↗
PubMed1975

Cell number and cell density in the cerebellar cortex of man and some other mammals.

The number of cells per unit volume was determined in the cerebellar cortex of man and 19 other mammals. The cell density (i.e. the number of cells per unit volume) decreases from mammals with a low brain weight to those with a higher brain weight. This decrease in the number of cells is found to be proportional for all three layers of the cerebellar cortex. In addition, the ratio of Purkinje cells to granule cells was determined. In contrast to the decrease of all cell types with increasing brain weight, this ratio varies remarkably among the mammals and is not correlated with brain weight. In man, this ratio is 1:2991, while it is lower in all other mammals investigated. These differences in the ratio of Purkinje cells to granule cells and the decrease in cell density with increasing brain weight are discussed in relation to brain evolution.

Animals↗
PubMed1975

[Antibodies against hepatitis B (surface) antigen in patients with hepatitis and other groups of epidemiologic interest (author's transl)].

Sera of patients with hepatitis A and B and of patients in a hemodialysis unit as well as sera of drug addicts were examined for the presence of antibodies against hepatitis B (surface) antigen (HBsAg) employing the Ausab test - a new radioimmunoassay. In 79.3% of the hepatitis B patients the occurrence of antibodies against HBsAg (anti-HBsAg) was noted after the HBsAg had disappeared. In hepatitis A patients anti-HBsAg could be detected in 15.5% (adults) and in 4.6% (children) respectively. These antibodies persisted over an observation period up to 15 months and were not connected with the apparent illness at the time of the examination. These results are rather an indication of the frequency of antibodies against HBsAg in the normal population. In two patients with hepatitis A a delayed antibody reaction similar to that seen in hepatitis B patients was observed though HBsAg could not be detected (Ausria 125 test). It is assumed that these patients suffered from hepatitis B which on the basis of the negative HBsAg status was diagnosed as hepatitis A. According to that observation not all cases of HBsAg negative hepatitis are necessarily of type A but occasionally of type B not detectable by means of HBsAg assay at that time. Drug addicts without hepatitis at the time of investigation showed 50.8% anti-HBsAg, in 24.3% HBsAg was detected by means of the Ausria 125 test. In 19 drug addicts with positive antigen or antibody status a history of hepatitis was established. Patients of the hemodialysis unit were found to be HBsAg carriers in 9.2% and anti-HBsAg carriers in 53.5%. The data obtained from drug addicts and dialysis patients point to a high risk of infection in both groups and to a frequent contact with HBsAg (booster) in dialysis units. The combined application of sensitive tests for the detection of antigen and antibodies (radioimmunoassays) with regard to epidemiological and anamnestic studies is recomended.

Adult↗
PubMed1975

[Tolerance of condenser impulses in cattle].

Extensive testing of electric fence equipment on cattle confirmed the effectiveness of the current intensities laid down by Koeppen and Osypka. Condenser discharges within the grade I of current intensity were tested for safety and effectiveness using standard equipment ("Cerberus" type). These condenser discharges were much more effective than induction current impulses. The risk of accidents to human beings and animals, and veterinary and zootechnical applications of condenser impulses were discussed.

Animals↗
PubMed1975

Antigenic subgroups of hepatitis B (surface) antigen in Berlin (West) and their epidemiological aspects.

Sera of 334 hepatitis B patients and 118 sera of HBsAg carriers were tested for the distribution of the subgroups ad and ay by means of rheophoresis technique or solid phase radiommunoassay. The distribution of subgroups revealed a typical pattern. The ad-antigen determinant was more frequent in hepatitis B patients, blood donors and hemodialysis patients whereas the ay determinant was detected in drug users, guest workers and juveniles at a considerably higher percentage. The difference in distribution is discussed as an epidemiological phenomenon of hepatitis B virus, dependent on environmental factors characteristic for certain groups of the population. The routine testing for HGsAg subgroups is recommended as a valuable epidemiologic tool.

Adolescent↗
PubMed1974

[Functional cytology of bovine adenohypophysis and the effects of mestranol and chlormadinone acetate].

The synthetic oestrogen mestranol, given by mouth to young bulls, appeared to stimulate chromophobe cells of the anterior lobe of the pituitary, indicating stimulation of ACTH secretion. The mass of the pituitary was also increased by administration of 5 mg mestranol daily for 130 days. This hypertrophy was prevented by a single intramuscular injection of chlormadinone acetate. The anterior epithelium of the hypophyseal cavity reacted tooestrogen administration by increased secretory activity.

Acetates↗
PubMed1974

[Promotion of fattening in young bulls following the administration of mestranol].

Oral administration of 5 mg mestranol daily for 100 days to 70 German Black Peid bulls improved weight gain in 72% of the animals. Average additional increment ranged from 2 to 17%. During the first weeks of administration there was a weak and transient protein-anabolic action and improvement in digestion of crude protein. Appetite was slightly stimulated. Consumption of food and energy per unit of weight gain was improved; better growth led to higher slaughter weight. Treatment had no effect on meat to bone ratio, degree of fulness of the gastointestinal tract, or meat quality. Skeletal mineralization was improved by 10-30%, and there was a noticeable anabolic effect on mineral metabolism. After longer administration an antigonadotropic action became evident. Some veterinary indications for use in fattening cattle were derived from these effects. Further pharmacological and clinical investigation of this and more active anabolics seemed to be required.

Animals↗