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Biomedical subjects

W L Morison

Publications and source records attributed to W L Morison.

At least 109 records · Page 6Linked to original sources
PubMed1981

The influence of ultraviolet radiation on allergic contact dermatitis in the guinea-pig. II. Psoralen/UVA radiation.

Guinea-pigs were sensitized by percutaneous application of dinitrochlorobenzene and exposed to UVA (320-400 nm) radiation following systemic administration of methoxsalen. This treatment diminished the response to an elicitation dose of the hapten administered 14 days later within the site of irradiation. The site of elicitation of the allergic response had to be included in the field of exposure, an reduction of the allergic response was observed only when the exposure to radiation was commenced at the time of induction of contact allergy. Established contact skin sensitivity was not affected by radiation.

Animals↗
PubMed1981

In vivo effects of PUVA on lymphocytes function.

Whole-body exposure to erythemogenic doses of PUVA in normal volunteer subjects resulted in a decrease in the proportion of circulating sheep erythrocyte rosette-forming and surface membrane immunoglobulin-positive lymphocytes and an increase in the proportion of null cells. Doses of PUVA resulting in minimal or no erythema had similar but less marked effects on lymphocytes. The changes appeared 30 min after exposure, were maximal at 12-16 h and returned to pre-treatment levels by 72 h post-irradiation. The response of lymphocytes to stimulation with phytohaemagglutinin was unaffected. No alteration occurred in the absolute numbers of circulating lymphocytes or polymorphonuclear leukocytes.

Adult↗
PubMed1980

The influence of PUVA and UVB radiation on skin-graft survival in rabbits.

The survival time of full-thickness skin grafts in rabbits was prolonged by administration of methoxsalen and subsequent exposure of the donor and recipient graft sites to longwave ultraviolet radiation (UVA). Erythemogenic doses of radiation were required to prolong graft survival. Similar exposure to mid-ultraviolet radiation (UVB) did not significantly prolong the survival time to grafts.

Animals↗
PubMed1979

Dermatological and ocular examinations in rabbits chronically photosensitized with methoxsalen.

Four groups of female Dutch-belted rabbits (Oryctulagus cuniculus) were given methoxsalen (12 mg/kg) or placebo by oral intubation and 1 hr later were exposed to UVA for either 2 or 8 hr. This procedure was repeated 5 days each week for 18 mo. A fifth group received no drug and no UVA exposure. The skin of the animals given methoxsalen and UVA showed signs of acute and chronic phototoxicity. Multiple peripheral blood parameters of hepatic, renal and hematologic function were normal and were not different between groups. Complete ophthalmoscopic examinations were performed periodically. No cataracts were seen in any of the animals. This data provides the perspective that in one species the daily dose of methoxsalen and UVA required to induce chronic cutaneous photosensitization is lower than the daily dose required to induce cataracts. It is inadvisable to interpret this data as suggesting that no risk exists for patients being treated with oral methoxsalen photochemotherapy. The experimental evidence supporting photosensitization as a cause of cataracts and implicating a role of lens DNA in this cataractogenesis is reviewed. Because methoxsalen-UVA alterations of lens DNA or protein could lead to delayed onset of cataracts, and because of the serious nature and potential preventability of phototoxic lens opacification, appropriate protective eye wear is recommended for all patients receiving oral psoralen photochemotherapy.

Animals↗
PubMed1979

Transient impairment of peripheral blood lymphocyte function during PUVA therapy.

Three parameters of immune function--enumeration of circulating T and B lymphocytes and response of lymphocytes to graduated doses of phytohaemagglutinin (PHA)--were examined serially in eleven patients with psoriasis before, during, and after an intensive course of PUVA therapy. A trend was detected for the lymphocyte response to PHA to fall during the first week of treatment and then rise back towards the pre-treatment level. No alteration was found in the percentage or absolute numbers of circulating T and B lymphocytes. This study shows that routine PUVA therapy can induce an alteration in immune function but that this alteration is slight and short-lived.

Adult↗
PubMed1979

Comparison of PUVA and beta-carotene in the treatment of polymorphous light eruption.

Therapy with oral psoralen photochemotherapy (PUVA) and oral beta-carotene was compared in 29 patients with polymorphous light eruption. Complete remission occurred in 90% (9/10) of those treated with PUVA and in 32% (6/19) treated with beta-carotene. In the six patients who were treated in consecutive years with both modalities all had remissions with PUVA while only two had remissions with beta-carotene.

Administration, Oral↗
PubMed1979

In vivo effect of UV-B on lymphocyte function.

Whole-body exposure of normal subjects to erythemogenic doses of UV-B radiation results in a decrease in the proportion of circulating E-rosette-forming lymphocytes, an increase in the proportion of null cells and a decreased incorporation of tritiated thymidine into DNA of lymphocytes following stimulation by phytohaemagglutinin (PHA). These alterations are dose-dependent, appear soon after exposure, reach a maximum after 8-12 h, and are reversed by 48-72 h post exposure.

Adult↗
PubMed1979

Photoimmunology.

Explore the source record for details and available documents.

Allergy and Immunology↗
PubMed1979

Antinuclear antibodies and oral methoxsalen photochemotherapy (PUVA) for psoriasis.

In view of theoretical concern that psoralen ultraviolet A radiation (PUVA) therapy might induce a systemic lupus erythematosus-like syndrome, we studied serum antinuclear antibodies (ANAs) in patients with psoriasis who received PUVA and are participating in a five-year prospective study. At 14 centers, 1,023 patients had two or more ANA determinations. When first and last tests were compared, the incidence of positive tests for ANAs was not significantly different (P greater than .2). In addition, there was no apparent relationship between the frequency of PUVA treatments and the probability of a positive test. Over a two-year period, there is no evidence to indicate that PUVA therapy for psoriasis has resulted in a significantly higher number of positive tests for ANAs within our population.

Adolescent↗
PubMed1979

Reticular erythematous mucinosis syndrome. Report of two cases.

Two female patients had eruptions with the morphologic and histologic features of reticular erythematous mucinosis syndrome. However, both cases had features that differed from previous descriptions. In one case the eruption developed three to four weeks after a single erythemogenic sun exposure and faded after two to three weeks. The rash could be reproduced by exposure to ultraviolet B (UVB) or UVC radiation. In the other patient, the eruption involved the arms and face and spared the trunk, which is a more characteristic site of involvement; it was associated with a history of exacerbation following sun exposure, but the rash could not be reproduced on phototesting.

Adult↗
PubMed1979

Oral methoxsalen photochemotherapy of uncommon photodermatoses.

Three uncommon idiopathic photodermatoses, refractory to other treatment, responded to oral psoralen photochemotherapy. Tow females with photosensitivity in association with atopy, one female with persistent light reaction following a systemic drug-induced photosensitivity and an elderly male with actinic reticuloid were treated.

Administration, Oral↗
PubMed1978

Therapy of psoriasis by tar photosensitization.

For the first time since Goeckerman suggested the therapeutic potential of tar photosensitization of psoriatic skin, this mechanism has been shown to the effective in treating generalized psoriasis vulgaris. Long treatment times, need for special high-intensity sources, the presence of skin pain, and absence of information about long-term effects makes this treatment impractical at present.

Humans↗
PubMed1978

Controlled study of PUVA and adjunctive topical therapy in the management of psoriasis.

In a random study of 116 patients with psoriasis vulgaris, oral psoralen photochemotherapy (PUVA) used alone was compared to PUVA plus adjunctive topical therapy with tar, dithranol, or topical corticosteroids. PUVA plus topical corticosteroids produced more rapid clearing of psoriasis but despite maintenance therapy, the frequency of recurrences of the disease during the early phase of follow-up was significantly higher with that treatment, as compared to all other treatments. Dithranol plus PUVA also cleared psoriasis quicker than PUVA alone but patient acceptability for that regimen was low. The addition of tar to PUVA therapy appeared to have little influence on results.

Adult↗
PubMed1978

Oral methoxsalen photochemotherapy of recalcitrant dermatoses of the palms and soles.

PUVA therapy successfully cleared various dermatoses mainly confined to the palms and soles in 18 of 20 patients treated. The conditions treated were: plaque-type psoriasis, pustular psoriasis, endogenous eczema and persistent palmoplantar pustulosis. Seventeen patients were treated in a controlled study of PUVA therapy versus no treatment at all and in 16 of these patients the disease was cleared in the PUVA-treated areas while the untreated areas remained unchanged or deteriorated. Twelve of the 18 patients were maintained in a clear state by continued maintenance PUVA treatment over 6--31 months while 3 patients had a spontaneous remission and are free of disease off all treatment.

Adolescent↗