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Biomedical subjects

W Klug

Publications and source records attributed to W Klug.

At least 37 records · Page 2Linked to original sources

[Surgery of proctologic diseases in the polyclinic].

The incidence of proctological diseases is on a rising trend, and some of them require surgical treatment. Outpatient handling is indicated, following thorough diagnosis, and in common practice worldwide. The surgical specialist, in command of pain-killing methods, is in a position to apply surgical treatment on a outpatient basis. Careful attention has to be given, in this context, to the anal complex and anal sanitation. Perianal thrombosis, incarcerated prolapsed haemorrhoids, acute anal fissure, and, with some reservation, periproctic abscess are situations in which acute action is recommended, while elective interventions seem to be indicated for chronic anal fissure, cryptitis, few anal fistulae, and perianal changes of the skin, but with limitations on the haemorrhoidal problem.

Abscess↗

Scintigraphic control of bone-fracture healing under ultrasonic stimulation: an animal experimental study.

In a model of closed lower-leg fracture in rabbits and of secondary bone-fracture healing, scintigraphic control until biological healing was performed. Biological fracture healing was assumed for a region of interest (ROI)-activity ratio close to 1.0. After application of 99mTc-HEDP, 151 examinations were performed. ROI activity increased significantly until day 14 p.i. and reached the maximum value (Q = 6.44) on day 14 postfracture. Sixty-one lower leg fractures were treated by ultrasound from days 14-28 postfracture. These stimulated fractures were biologically healed on day 168 postfracture. The fractures that were not treated by ultrasound could not be detected by scanning after day 203 postfracture.

Animals↗

[Animal experimental scintigraphic observations of the course of secondary fracture healing without and with ultrasound stimulation].

The scintigraphic course observation until the biologic fracture healing took place on the fracture model of the closed lower leg fracture with secondary fracture healing in rabbit. 151 scintigraphic investigations were carried out by means of 99mTc HEDP. The ROI activity quotient increased significantly on the 14th day after the fracture up to the maximum value Q = 6.44. 61 fractures of the lower leg were treated by ultrasound from the 14th to the 28th day after the fracture. These stimulated fractures showed a biologic healing on the 168th day already. The fractures treated without ultrasound could not be proved any more scintigraphically after the 203rd day after the fracture.

Animals↗

[Anal fissure].

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Acute Disease↗

[Angiographic demonstration of the medullary space and callus vessels during secondary bone fracture healing; animal experiments].

The artery nutritia ruptured in a closed transverse fracture of the tibia in 86% during the fracture trauma. Because blood vessels go through between the periost and the metaphysial medullary space it does not come to an ischemia in the medullary space of the distal fragment. The periosteal and paraosseous revascularisation increased with the extension of the fragment shifting. The artery nutritia is recombinated spontaneously in the complete cross section after 10 weeks. A good demonstration of the callus vessels is attainable by lumbar aortography with barium sulphate.

Angiography↗

[Levels of alkaline phosphatase, quantity and trace elements in the serum and compact bone in the rabbit].

One can find only little information about the quantitative analysis of quantity elements and trace elements in animal bone compact substance and blood serum. The authors analysed potassium, sodium, phosphorus, calcium, iron, copper, zinc, and the alkaline phosphatase in the blood serum and in the compact substance of the tibial shaft of the rabbit. The collection and the preparation of blood serum and bone for the analytic investigation and the analysis methods were shown. The concentration of the inorganic elements were determined in mol/l and the content were calculated on 1 g dry bone substance.

Alkaline Phosphatase↗

[Quantity and trace elements in callus in secondary fracture healing; animal experiment study].

The quantitative analysis of quantity elements and trace elements in the callus tissue of tibial fractures was carried out in 120 adult rabbits during the secondary bone fracture healing. The processing of the callus and the analysis methods of the inorganic elements were demonstrated. The trace elements copper and zinc are available much more compared with the quantity elements in the callus tissue during the acidotic early phase of the fracture healing. Copper and zinc are necessary for synthesis of the bone substance and the enzymes. The phosphorus concentration increased in a three-phasic way in the callus during the fracture healing. Phosphorus is prematurely enriched in the callus quantitatively stronger than calcium.

Animals↗

[Experimental phantoms for studying diagnostic and therapeutic procedures of the rectosigmoid and upper colon].

The authors represent lifelike exercise models for the training without patient of diagnostic and therapeutic interventions in the rectosigmoid and in the colon. The two models are used for the practical training of the rectosigmoidoscopy with the rigid rectoscope and the coloscopy with the fibre-optical examination technique. In the excorporated animal rectum may be performed polypectomies by means of removal of the loop, exploratory excisions from the intestinal wall as well as electro-surgical and cryosurgical interventions. The experiences got up to now in training classes are described.

Animals↗