Biomedical subjects

W Jones

Publications and source records attributed to W Jones.

219 records · Page 13Linked to original sources

PubMedDate not supplied

Intraperitoneal therapy in the management of ovarian carcinoma.

The intraperitoneal administration of chemotherapeutic and biological agents as therapy of ovarian carcinoma is based on both theoretical considerations and experimental evaluations which suggest that tumor present in the cavity can be exposed to higher concentrations of certain antineoplastic drugs than can be accomplished if the agents are administered systemically. Recent clinical data have confirmed both the safety and pharmacokinetic advantage associated with this approach. Surgically defined responses have been observed in patients with small-volume residual refractory ovarian carcinoma treated with several single-agent and combination intraperitoneal therapeutic programs. While significant activity has been noted in this clinical setting, a clearly defined role for intraperitoneal treatment in the standard management of ovarian carcinoma remains to be determined.

Antineoplastic Agents↗

PubMedDate not supplied

Preventing mental disorders in the minority community.

Studies in community mental health have noted a disproportionate incidence of mental illness in minority populations. However, it is impossible to document its true extent without a proper data base. Most of our knowledge is based on reports from institutions and social service agencies--coroner's offices, police departments, and various treatment programs. The resulting distortion of the data makes it difficult to develop prevention policies and programs. Further, the politics incurred in implementing programs in minority communities suggest that there are political barriers to providing such services. This paper examines these critical political-social factors.

Humans↗

PubMedDate not supplied

Immunisation of macaques with SIV env recombinants: specificity of T cell and antibody responses and evaluation of protective efficacy.

Macaques were immunised with lentil lectin purified recombinant SIVmac (BK28) derived gp160 (rgp160) with or without live vaccinia (vac)-env (BK28) priming, followed by a final boost with solid matrix antibody antigen (SMAA)-gp160 (J5) complexes and challenged with the SIVmac molecularly cloned virus J5M. Rgp160 and vac-env plus gp160 induced strong Ab responses against the homologous virus. Live vac-env did not enhance or prolong the antibody response, however, T cell responses were stronger. Analysis of the specificity of the immune response demonstrated that sequence variation within SIVmac viruses can affect antibody and T cell recognition. A single booster immunisation with the heterologous SIVmac J5 env recombinant protein was not sufficient to protect against the molecularly cloned virus J5M. These findings further illustrate the difficulty of generating protective immunity with immunogens based on single sequence recombinants.

Amino Acid Sequence↗