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Biomedical subjects

W Jeske

Publications and source records attributed to W Jeske.

At least 109 records · Page 6Linked to original sources
PubMed1987

The role of opiate, dopaminergic, and adrenergic systems in the hypothalamo-pituitary dysfunction in obesity.

UNLABELLED: In order to evaluate the role of opiate, dopaminergic and adrenergic systems in the mechanism of hypothalamo-pituitary disturbances in obesity, 9 obese women and 14 healthy women were investigated. Serum GH, LH, beta-endorphin and cortisol concentrations were measured after administration of clonidine, an alpha 2-adrenergic receptor agonist, and naloxone, an opiate antagonist. Additionally, PRL levels were measured after administration of the dopamine receptor blocker metoclopramide. An impaired GH response to clonidine and naloxone was found in obese women. However, a marked increase in beta-endorphin was observed in obese patients after clonidine administration. Naloxone did not cause any significant change in beta-endorphin release. Neither clonidine nor naloxone induced any change in LH release. Serum PRL concentrations in response to metoclopramide were significantly higher in obese patients than in healthy women. IN CONCLUSION: Disturbed activity in opiate, adrenergic, and dopaminergic systems may be of pathogenetic importance in a hypothalamo-pituitary dysfunction in obesity. The occurrence of hypothalamic amenorrhoea as well as the presence of abnormalities of the central nervous system regulation of GH, PRL, ACTH, cortisol, insulin and vasopressin output might point to a generalized hypothalamo-pituitary dysfunction in obesity.

Adolescent↗
PubMed1986

Plasma ACTH levels and beta-endorphin-like immunoreactivity following administration of luteinizing hormone-releasing hormone in Nelson's syndrome.

The effect of LH-RH (25 micrograms as a single i.v. bolus) on plasma corticotropin (ACTH) levels and beta-endorphin-like immunoreactivity was studied at 30 and 60 min in eight women with Nelson's syndrome. Plasma ACTH concentrations increased in three of them, while beta-endorphin-like immunoreactivity, measured in six cases, rose significantly at 30 min in all the patients under investigation. In the control group containing seven women with Nelson's syndrome, placebo (0.9% sodium chloride) administration did not induce any significant changes in ACTH concentrations or in beta-endorphin-like immunoreactivity. Our results suggest that a paradoxical stimulatory influence of LH-RH on pituitary Nelson's adenomas may play an important role in the adenoma hormonal activity and, perhaps, growth. Such an effect could be responsible for a rapid development of some pituitary neoplasms during pregnancy.

Adenoma↗
PubMed1986

[No age dependence of biochemical parameters in pregnancy].

The parameters AFP, progesterone, HPL, estriol, SP1 and beta-HCG were evaluated in the sera of 994 pregnant women. The women were in the 5th to 25th weeks of pregnancy. Evaluation was carried out by means of radioimmunoassay and radial immunodiffusion. In collecting the data, we wished to determine whether there was a relationship between the age of the pregnant woman and the changes in parameter values during the course of the pregnancy. With the exception of beta-HCG concentrations, no age dependency was observed. However, the beta-HCG/age interrelationship was minor and without practical consequence.

Adolescent↗