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Biomedical subjects

W Jaeger

Publications and source records attributed to W Jaeger.

At least 91 records · Page 5Linked to original sources
PubMed1980

Posterior polymorphous dystrophy of the cornea (Schlichting). An unusual clinical variant.

Three members of a family with dominant inherited endothelial dystrophy of the cornea are described. The father showed only subclinical disease with subtle endothelial blisters like those found in Schlichting's dystrophy. His daughter and grandson, however, both suffered from a peculiar, prominent, ring-shaped clouding of the cornea which progressed to severe edema, necessitating keratoplasty. Light, transmission, and scanning electron microscopy revealed an epithelial transformation of the endothelium. While the anterior banded part of Descemet's membrane was well-formed in the central cornea, it was missing in the periphery. This corresponded with the ring-shaped opacity and indicated a very early transformation of the endothelium in this area. We believe that this pedigree represents an unusual clinical variant of posterior polymorphous dystrophy of the cornea.

Adult↗
PubMed1979

[X-linked night-blindness: clinical and electrophysiological investigations including de-ERG in two families (author's transl)].

Patients from two families with X-linked recessive nyctalopia and myopia were investigated. The functional tests included clinical examinations (visual acuity, color sense, visual fields, dark adaptation) and electrophysiological examinations (ac coupled ERG, dc-coupled ERG, EOG). The dc-coupled ERG registrations were done without general anesthesia. In one case, a comparison with results obtained in 1967 was possible. There was no evidence of increase in functional impairment. On the basis of the electrophysiological results, the nature and localization of the defect causing nyctalopia are discussed. The postreceptoral retinal structures appear not to be involved exclusively.

Adult↗
PubMed1979

[Applications of novel stereomicroscopic spectacles in ophthalmic surgery (author's transl)].

The previous magnifying spectacles and telescopic spectacles designed on the principle of the Galilean telescope have a magnification of only 2.5 x to 3 x for good image quality. New magnifying systems from Zeiss based on the Kepler telescope principle offer 3 x to 8 x magnification and thus cover the range between magnifying spectacles and operation microscopes and even come into the latter range. The following versions are available for ocular surgery: 1. Mounted on headband. 2. Fastened to the frame in front of the lenses. 3. Cemented into drilled holes in the lenses with additional horizontal connection of the magnifying systems. 4. Cemented into drilled holes in the lenses without horizontal connection. These versions offer different advantages and are selected according to the particular field of application and the refraction of the surgeon. With these compact and easily transportable stereomicroscopic systems the surgeon has complete freedom of movement being able to select the most convenient position at any stage of the examination or operation. Further applications of such stereomicroscopic spectacles beyond the field of ophthalmic surgery are mentioned.

Eye Diseases↗
PubMed1978

Differential diagnosis of typical and atypical congenital achromatopsia. Analysis of a progressive foveal dystrophy and a nonprogressive oligo-cone trichromasy (general cone dysfunction without achromatopsia), both of which at first had been diagnosed as achromatopsia.

Report on two patients whose symptoms suggested the presence of congenital achromatopsia. In one case there was indeed total colour blindness, but a normal photopic ERG. Here, achromatopsia is the present stage in a process of slow functional decay of the central retina. Most probably the underlying disorder is progressive foveal dystrophy, a central form of cone dystrophy. In the other case there was a nonrecordable photopic ERG, but trichromatic colour vision. This appears to be another patient with oligo-cone trichromasy (general cone dysfunction without achromatopsia), as described by Van Lith.

Adult↗
PubMed1978

[Herpetiform bilateral epithelial corneal dystrophy caused by Tyrosinemia (Richner-Hanhart-Syndrome) (author's transl)].

Nutritional Tyrosinemia in animal experiments (Schweizer, Burns a. o.) caused an epithelial corneal dystrophy. The corresponding clinical picture is the Richner-Hanhart-Syndrome with herpetiform epithelial corneal dystrophy, palmo-plantar-keratosis and -- in some case -- a later developing oligophrenia. Goldsmith and coworkers suceeded to find out that all these symptoms are combined with tyrosinemia presumably caused ty one congenital enzyme defect. -- Personal clinical observations of such patients demonstrate that as well the corneal as the dermatological symptoms could be cured by diet, if the diagnosis is made in childhood. Corneal symptoms are still absent with a tyrosinemia as high as 10 mg%. Dietetic formula was found out to maintain this level, which is low enough to avoid the symptoms of Richner-Hanhart-Syndrome and certainly high enough to avoid symptoms of nutritional deficiency. One might expect that oligophrenia will not develop if this diet is used consequently. -- Since the first corneal symptoms develop already during the first years of life the ophthalmologist ought to know this etiology. The levels of tyrosinemia are so exorbitant (30--50 mg%) that the laboratory diagnosis is possible without any difficulty. If the diagnosis is only made in adult patients dietetic therapy is of limited value.

Age Factors↗
PubMed1977

[Arcus senilis].

Explore the source record for details and available documents.

Adult↗
PubMed1977

[Acquired colour-vision-deficiencies caused by side-effects of pharmacotherapy (author's transl)].

Acquired colour-vision deficiencies are an early indicator for drug-induced retinopathy as well as drug-induced retrobulbar neuritis. Koellner's rule, which says, that damage of the retina induces a tritan-defect, and damage of the optic nerve induce a red-green-defect is also valid for defects secondary to drug-toxicity. Pseudoisochromatic plates, anomaloscope and other tests (Panel D-15-test) have to be selected correspondingly to use them as screening-methods.

Antipsychotic Agents↗
PubMed1977

[The diagnostic value of corneal arcus as symptom of hyperlipoproteinemia (author's transl)].

In the normal population a physiologic arcus senilis develops in the 6th and the following decades. Hyperlipoproteinemia (type II a and type II b) however may be the cause of an earlier onset of a corneal arcus. 63 patients with hyperlipoproteinemia type II a and type II b were examined with slit-lamp. In more than 75% of these patients corneal arcus were found already in the 5th decade. Normal population of the same age in contrast shows an arcus corneae only in 25%. Prospective examinations of the Western Collaborative Group found out, that men, 39-49 years old, had with corneal arcus a significantly higher incidence of coronary heart disease, compared with those without arcus. The average annual incidence of symptomatic myocardial infarction was 6.8 per 1000 with arcus as compared to 3.2 per 1000 without. In the 6th decade however there was no more any difference between subjects with arcus and those without arcus. These results, together with the findings of our study, show that one ought to examine the blood-lipids, if by chance of the first refraction a fully developed arcus corneae is found.

Adult↗