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Biomedical subjects

W J Ryan

Publications and source records attributed to W J Ryan.

At least 37 records · Page 2Linked to original sources
PubMed1990

Effects of position changes on mixed venous oxygen saturation in patients after coronary revascularization.

The purpose of this study was to investigate the effects of position changes on mixed venous oxygen saturation (SvO2) and to describe the mechanisms responsible for SvO2 changes reported to occur with position changes. The study was done from 4 to 8 hours after surgery in 34 patients after coronary artery bypass grafting. Subjects were put through a series of six position changes, including head of bed elevations and right and left lateral decubitus with return to supine between each. Each position was maintained for 30 minutes. SvO2, arterial oxygen saturation (SaO2), and oxygen consumption (VO2) were measured before and after each position change. Overall mean subject data demonstrated a decrease in SvO2 with each of the lateral position changes. The SvO2 did not drop below 60% in these mean data, and this drop returned to baseline by 5 minutes. There were no significant changes in the mean data for VO2 or SaO2. No significant correlation was found in the mean data between SvO2 and VO2 or SvO2 and SaO2 measurements. Trends were demonstrated in five specific cases that suggested a correlation between changes in SvO2 and changes in VO2 and SaO2. In conclusion, this study demonstrated that subjects were able to tolerate position changes with no clinically significant changes in SvO2, SaO2, or VO2.

Aged↗
PubMed1989

The access of relevant information for solving problems.

Two issues were investigated concerning the retrieval of recently acquired relevant information for solving riddle problems. First, although earlier research indicated that problem solvers often fail to retrieve relevant information unless they are explicitly informed of its relevance, Bowden (1985) suggested that uninformed subjects would benefit greatly from additional problem-solving time. In two experiments, we found that uninformed subjects solved more problems than did subjects who did not receive the information, but a simple model attributed this difference to these uninformed subjects "catching on" to the information's relevance after solving some problems. Second, the retrieval characteristics were examined by varying the proportion of problems for which clues were given. Informed subjects given clues for only half of the problems benefited (though perhaps not fully) from being informed, without incurring any cost from being misdirected on the unclued problems. The discussion focuses on some ways in which accessing relevant information may affect problem solving.

Adult↗
PubMed1986

Effect of concurrent topical corticosteroid and NSAID therapy of experimental keratitis.

The ability of suprofen, a nonsteroidal anti-inflammatory drug, and prednisolone acetate, a corticosteroid, to suppress polymorphonuclear leukocyte invasion of the rabbit cornea during an experimental keratitis was evaluated following topical ophthalmic administration of either drug alone or both drugs concurrently. Suprofen therapy initiated immediately after induction of inflammation was ineffective. However, if suprofen therapy was begun 48 hr prior to the induction of inflammation, the drug was effective. In contrast, prednisolone acetate therapy begun after the induction of inflammation was effective; 48 hr of pretreatment with the corticosteroid produced a marked increase in its therapeutic effect. When administered according to the same regimen, concurrent therapy with suprofen and prednisolone acetate was significantly more effective than treatment with either drug alone. This result was obtained irrespective of whether concurrent therapy was initiated prior to or after the inflammatory event.

Administration, Topical↗
PubMed1986

Bioavailability and corneal anti-inflammatory effect of topical suprofen.

The bioavailability in rabbit cornea and aqueous humor of an ophthalmic formulation of suprofen, a nonsteroidal anti-inflammatory drug, was evaluated following topical administration of a single dose to the eye. The drug penetrated rapidly into the uninflamed cornea with intact epithelium; highest levels occurred during the first 30 to 45 min after instillation and decreased thereafter. The bioavailability of suprofen in cornea and aqueous humor following administration of a 1.0% concentration was twice that produced by a 0.5% concentration of the drug. Topical application of multiple doses of suprofen failed to suppress polymorphonuclear leukocyte invasion of the cornea if treatment was started after the induction of inflammation. Suprofen therapy initiated prior to the induction of corneal inflammation and maintained into the post-inflammation period did produce a significant (P less than 0.01) decrease in the numbers of PMNs that invaded the inflamed cornea. There was no significant difference (P greater than 0.05) in the corneal anti-inflammatory effect achieved by the 0.5% and 1.0% concentrations of suprofen when administered according to this regimen.

Animals↗
PubMed1985

Quantitation of herpes simplex virus in rabbit corneal epithelium.

The authors have developed an objective method for quantitation of herpes simplex virus in the corneal epithelium of rabbits. At appropriate times postinfection, full-thickness rabbit corneas were removed by trephination and subjected to one cycle of freezing and thawing. The corneal epithelium was then disrupted by sonication. The amount of infectious virus recovered from sonicated specimens was determined by an in vitro plaque assay, providing a measure of the quantity of virus present during the acute stage of herpetic keratitis. Using this technique, the authors found that the mean virus titer was reduced from 1.5 X 10(5) plaque forming units (pfu) per cornea in control rabbits to less than 200 pfu per cornea in rabbits treated topically for 2 days with 1% trifluridine. In contrast, instillation of 1% prednisolone acetate resulted in the persistence of higher levels of virus (275 pfu) than those observed in control rabbits (3 pfu) 4 days after the cessation of therapy.

Animals↗
PubMed1981

Route of antibiotic administration in bacterial keratitis.

The in vivo antibacterial effectiveness in the rabbit cornea of several antibiotics delivered by topical application, by periocular injection, and by intravenous (IV) inoculation was determined against Staphylococcus aureus and Pseudomonas aeruginosa. Topical instillation of antibiotic was highly effective in eliminating these organisms from the cornea. In contrast, despite a considerable increase in the quantity of antibiotic administered, we could demonstrate no statistically significant reduction in the number of viable staphylococcal or Pseudomonas organisms in the cornea when the antibiotic was given by periocular or by IV injection.

Administration, Topical↗
PubMed1981

Prolongation of anti-inflammatory effect of prednisolone acetate. Influence of formulation in high-viscosity gel.

Prednisolone acetate was formulated in a high-viscosity carboxypolymethylene gel at concentrations of 0.125% and 1.0%. The ability of these gel preparations to suppress inflammation in the cornea was assessed and compared with the antiinflammatory capabilities of conventional commercially available prednisolone acetate ophthalmic suspensions. When administered hourly, the gel formulations produced no greater anti-inflammatory effect than the conventional suspensions. However, the gel formulations were equal in effect to the suspensions and maintained their effects considerably longer than did the suspensions. When applied at intervals up to and including four hours, there was no falloff in effect; the gel demonstrated a level of anti-inflammatory effectiveness that could not be distinguished from hourly administration of the suspension.

Animals↗
PubMed1979

Cyclic AMP formation and release by cultured bone cells stimulated with prostaglandin E2.

PGE2 produced a marked and dose-related increase in cAMP content of cultured bone cells and in the release of cAMP into the incubation medium. The amount of cAMP released from the cells by PGE2 was proportional to the cellular concentration, and was dependent upon the time of incubation with PGE2. The cAMP levels released into the media increased slowly at a linear rate during a 60 min treatment with PGE2. This release was blocked by theophylline, probenecid, ouabain and dinitrophenol, suggesting that the release of cAMP was not a simple diffusive process and required energy. SC-19220 reduced the formation of cAMP more than the release, suggesting that the formation and the release may arise from separate events. Inability of D600 to inhibit PGE2-induced release of cAMP indicates that the release does not require calcium.

Animals↗