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Biomedical subjects

W Hung

Publications and source records attributed to W Hung.

At least 37 records · Page 2Linked to original sources
PubMed1984

Growth hormone neurosecretory dysfunction. A treatable cause of short stature.

Pulsatile growth hormone (GH) secretion was assessed in a subgroup of short children to determine whether they had GH secretory abnormalities, and these results were compared with those of normal and GH-deficient children. This subgroup of children was defined as having GH neurosecretory dysfunction and met the following criteria: height, less than first percentile; growth velocity, 4 cm/yr or less; bone age, two or more years behind chronological age, normal findings from provocative GH tests (peak, greater than or equal to 10 ng/mL), low somatomedin-C level, and abnormal 24-hour GH secretory patterns. When compared with controls, both children with GH neurosecretory dysfunction and GH-deficient patients had a significant decrease in parameters relating to the total GH secretion during the 24-hour period. As with GH-deficient children, the group with GH neurosecretory dysfunction more than doubled their growth velocity after replacement therapy with exogenous human GH during the first year of treatment. As a result of these detailed studies on pulsatile GH secretion, we suggest that there is a spectrum of GH secretory abnormalities from absolute deficiency to an intermittent irregularity in GH secretion.

Adolescent↗
PubMed1984

The effects of sex steroids on ulnar growth during adolescence.

To investigate the relative effects of androgens and estrogens on long bone growth, we evaluated the 3-week ulnar growth velocities of 10 boys before and after the iv administration of testosterone (T; 15 mg/day), dihydrotestosterone (DHT; 7 mg/day), and estradiol (E2; 90 micrograms/day) for 4 days. Ulnar growth is a sensitive index of short term growth in children. Mean 3-week ulnar growth velocities increased from 0.49 +/- 0.11 (+/- SEM) to 1.09 +/- 0.14 mm/3 weeks after the T infusion (P less than 0.005), from 0.42 +/- 0.09 to 0.84 +/- 0.13 mm/3 weeks after the DHT infusion (P less than 0.02), and from 0.67 +/- 0.07 to 0.96 +/- 0.26 mm/3 weeks after the E2 infusion (P = NS). The mean T level was 2555 +/- 234 ng/dl during the T infusion. Mean E2 levels were 53 +/- 4 pg/ml during the T infusion and 102 +/- 7 pg/ml during the E2 infusion. Mean DHT levels were 73 +/- 7 ng/dl during the T infusion and 1115 +/- 124 ng/dl during the DHT infusion. Mean somatomedin-C levels increased to a similar degree during all infusions, but were significantly higher only during the E2 infusion (P less than 0.01). We conclude that T and DHT given for 4 days stimulated ulnar growth, while E2 at concentrations greater than those derived from T did not cause a significant increase in ulnar growth. None of the ulnar growth rates after T, DHT, or E2 treatment, however, differed significantly.

Adolescent↗
PubMed1983

L-glutamine D-fructose-6-P aminotransferase regulation by glucose-6-P and UDP-N-acetylglucosamine.

L-Glutamine D-Fructose-6-P aminotransferase regulates hexosamine synthesis. An affinity purified human fibroblast aminotransferase and specific radioisotope assays developed by us were used to show an independent inhibition of the aminotransferase by Glucose-6-P. More interestingly, at concentration of UDP-N-Acetylglucosamine and glucose-6-P where either sugar has no independent inhibitory effect, there is an allosteric and significant inhibition of the aminotransferase.

Allosteric Regulation↗
PubMed1982

Solitary thyroid nodules in children and adolescents.

Thirty-nine children and adolescents with a solitary nodule of the thyroid gland were seen over a 16-yr period and 35 had their nodules removed surgically. All of the patients had preoperative thyroid scintiscans, of which 27 showed a cold nodule. The most common cause of solitary thyroid nodules was follicular adenoma. Five of the 27 cold nodules were malignant (18.5%) while no malignancies were present in the warm or hot nodules. Available diagnostic methods of attempting differentiation of benign from malignant solitary nodules are reviewed and an approach to the clinical management of such nodules as derived from our experience is presented.

Adenoma↗
PubMed1980

Computerized tomography in the evaluation of isosexual precocity.

Clinical and laboratory observations were made in three children with isosexual precocity. None of the patients showed abnormalities in neurological or visual-field examinations although one patient had arrested hydrocephalus and a head circumference greater than the 98th percentile for her age and another patient had a history of seizures. Roentgenograms of the skull were normal in all patients. Cranial computerized tomography (CT) identified a lesion in each patient. We believe that craniel CT should be performed in any patient with isosexual precocity in whom a specific cause is not evident or in whom a cerebral cause is suggested even though the patient may be otherwise normal. Cranial CT is a safe, accurate, and noninvasive technique.

Brain Diseases↗
PubMed1979

Hyperreninemia and secondary hyperaldosteronism in pheochromocytomas.

Foremost in the differential diagnosis of hypertension is the identification of surgically correctable lesions. Increased plasma renin activity in a hypertensive patient suggests the presence of a renovascular or renal etiology. We have recently seen two adolescent patients whose hyperreninemia was cuased by a pheochromocytoma. Secondary hyperaldosteronism was an associated finding.

Adolescent↗
PubMed1979

The effects of stimulant medication on the growth of hyperkinetic children.

This article reviews the literature on possible growth-suppressing effects of stimulant medications in the long-term treatment of children with the hyperkinetic behavior syndrome. The evidence clearly indicates a temporary retardation in the rate of growth in weight and suggests a temporary slowing of growth in stature, but no effect on adult stature or weight. This temporary effect on growth is present during the first few years of treatment and seems related to drug dosage and to the presence or absence of drug holidays. These conclusions related specifically to treatment during the prepubertal period; little is known of the growth-related effects of treatment extending through pubescence.

Adolescent↗
PubMed1978

Hemodialysis and thyroid functions in children.

Evaluation of thyroid functions in 16 children receiving maintenance hemodialysis for a mean duration of 17 months showed that the serum T3, T4 and TSH were below normal concentrations for age. However, the measurements of these variables before and after the dialysis procedure did not show any significant changes. The possibility that the chronic uremia may give rise to abnormal TSH secretion and low T3, T4 concentrations is not tested in this study.

Adolescent↗
PubMed1978

Hyperthyroidism in juvenile diabetes mellitus.

Three cases of hyperthyroidism occurring in juvenile patients with diabetes mellitus are presented. The presence of hyperthyroidism should be suspected in patients with diabetes mellitus when goiters develop and when there is unexplained weight loss, tachycardia, tremors, unexplained increases in insulin requirement, or instability of the diabetes with a tendency toward development of ketosis and/or ketoacidosis.

Body Weight↗
PubMed1977

Calcitonin therapy of children with osteogenesis imperfecta.

Two children, ages 13 2/12 and 6 6/12 years, with osteogenesis imperfecta were treated with salmon calcitonin. During the course of therapy the older child developed calcitonin dose-related hypomagnesemia on two occasions. The younger child, coincident with otitis media and vomiting, developed hypomagnesemia, hypophosphatemia, hyponatremia, and hypokalemia. Since rib biopsies obtained before and after one year of treatment with salmon calcitonin failed to demonstrate any histologic changes, therapy was discontinued because of the induced metabolic consequences of calcitonin therapy.

Adolescent↗
PubMed1976

Impaired glucose, insulin, and adenosine 3',5'-monophosphate responses to glucagon in growth hormone deficient children.

The glucose, insulin, and adenosine 3',5'-monophosphate (cyclic AMP) responses to intravenous glucagon were found to be impaired in growth hormone deficient children. The delta plasma glucose response in 22 normal children was 54.5 mg/dl compared to 38.4 mg/dl in the 11 growth hormone deficient children; t = 2.74, P less than 0.02. For serum insulin, the comparative values were 65.3 muU/ml (n = 20) vs. 29.8 muU/ml (n = 11); t = 3.03, P less than 0.01. For urinary cyclic AMP, the comparative values were 0.46 mumol/m2 (n = 22) vs. 0.18 mumol/m2 (n = 10); t = 2.48, P less than 0.02. Growth hormone therapy resulted in a significant improvement in the glucose, insulin, and cyclic AMP responses to intravenous glucagon in the growth hormone deficient group of children.

Adolescent↗
PubMed1976

Nerve conduction velocity determinations in juvenile diabetes: continuing study of 190 patients.

Few prospective studies on the concomitant finding of neuropathy in juvenile diabetics exist. An ongoing study of motor and sensory nerve conduction determinations in 190 diabetic children, with sequential studies in 108 of them over an eight-year period, is the subject of this report. The incidence of neuropathy in our sample population under five years of age is neglible. In the children over five years of age, 8% had abnormal nerve conduction velocity (NCV) of the peroneal nerve, 4.5% had abnormal median motor and sensory NCV on initial study. In the sequential studies of the children over five years of age, the percentage of abnormal NCV rose from 14% to 48% as the duration of diabetes increased from one year to more than five years. It is the older juvenile diabetics with the longest duration of diabetes who would appear to have the highest incidence of neuropathy.

Adolescent↗