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Biomedical subjects

W Hung

Publications and source records attributed to W Hung.

At least 19 recordsLinked to original sources
PubMed1992

Solitary thyroid nodules in 71 children and adolescents.

Seventy-one children and adolescents with a solitary nodule of the thyroid gland were seen over a 27-year period and all had their nodules removed surgically. All of the patients had preoperative thyroid scintiscans, 55 of which showed a cold nodule. The most common cause of solitary thyroid nodules was follicular adenoma. Fourteen of the 55 cold nodules were malignant (25.5%) while no malignancies were present in warm or hot nodules. Available diagnostic methods for attempting differentiation of benign from malignant solitary nodules are reviewed and recommendations to their clinical management as derived from our experience are presented.

Adolescent↗
PubMed1992

The primary empty-sella syndrome and diabetes insipidus in a child.

The empty-sella syndrome is uncommon in pediatric patients. Hypothalamic-pituitary dysfunction is common in these patients but involvement of the posterior pituitary gland is very rare. We report a seven-year-old girl with empty-sella syndrome who first developed arginine-vasopressin deficient diabetes insipidus and then anterior pituitary gland deficiency. The empty-sella syndrome should be included among the causes of arginine-vasopressin deficient diabetes insipidus in pediatric patients.

Child↗
PubMed1991

Sonography in neonatal congenital adrenal hyperplasia.

Adrenal gland size was evaluated in six infants with congenital adrenal hyperplasia. All of the infants had a severe deficiency of the 21-hydroxylase enzyme resulting in the salt-losing form of congenital adrenal hyperplasia. The adrenal measurements were compared with those of 40 consecutive age-matched, asymptomatic infants. Mean adrenal length was 14.4 mm and width was 1.9 mm in asymptomatic infants, whereas in infants with congenital adrenal hyperplasia mean adrenal length was 23.7 mm and width was 5.3 mm. Although infants with congenital adrenal hyperplasia may have normal-sized adrenal glands, mean length measurements of 20 mm or greater and mean width measurements of 4 mm or greater suggest the diagnosis.

Adrenal Glands↗
PubMed1979

Hyperreninemia and secondary hyperaldosteronism in pheochromocytomas.

Foremost in the differential diagnosis of hypertension is the identification of surgically correctable lesions. Increased plasma renin activity in a hypertensive patient suggests the presence of a renovascular or renal etiology. We have recently seen two adolescent patients whose hyperreninemia was cuased by a pheochromocytoma. Secondary hyperaldosteronism was an associated finding.

Adolescent↗
PubMed1979

The effects of stimulant medication on the growth of hyperkinetic children.

This article reviews the literature on possible growth-suppressing effects of stimulant medications in the long-term treatment of children with the hyperkinetic behavior syndrome. The evidence clearly indicates a temporary retardation in the rate of growth in weight and suggests a temporary slowing of growth in stature, but no effect on adult stature or weight. This temporary effect on growth is present during the first few years of treatment and seems related to drug dosage and to the presence or absence of drug holidays. These conclusions related specifically to treatment during the prepubertal period; little is known of the growth-related effects of treatment extending through pubescence.

Adolescent↗
PubMed1978

Hemodialysis and thyroid functions in children.

Evaluation of thyroid functions in 16 children receiving maintenance hemodialysis for a mean duration of 17 months showed that the serum T3, T4 and TSH were below normal concentrations for age. However, the measurements of these variables before and after the dialysis procedure did not show any significant changes. The possibility that the chronic uremia may give rise to abnormal TSH secretion and low T3, T4 concentrations is not tested in this study.

Adolescent↗
PubMed1978

Hyperthyroidism in juvenile diabetes mellitus.

Three cases of hyperthyroidism occurring in juvenile patients with diabetes mellitus are presented. The presence of hyperthyroidism should be suspected in patients with diabetes mellitus when goiters develop and when there is unexplained weight loss, tachycardia, tremors, unexplained increases in insulin requirement, or instability of the diabetes with a tendency toward development of ketosis and/or ketoacidosis.

Body Weight↗
PubMed1977

Calcitonin therapy of children with osteogenesis imperfecta.

Two children, ages 13 2/12 and 6 6/12 years, with osteogenesis imperfecta were treated with salmon calcitonin. During the course of therapy the older child developed calcitonin dose-related hypomagnesemia on two occasions. The younger child, coincident with otitis media and vomiting, developed hypomagnesemia, hypophosphatemia, hyponatremia, and hypokalemia. Since rib biopsies obtained before and after one year of treatment with salmon calcitonin failed to demonstrate any histologic changes, therapy was discontinued because of the induced metabolic consequences of calcitonin therapy.

Adolescent↗
PubMed1976

Impaired glucose, insulin, and adenosine 3',5'-monophosphate responses to glucagon in growth hormone deficient children.

The glucose, insulin, and adenosine 3',5'-monophosphate (cyclic AMP) responses to intravenous glucagon were found to be impaired in growth hormone deficient children. The delta plasma glucose response in 22 normal children was 54.5 mg/dl compared to 38.4 mg/dl in the 11 growth hormone deficient children; t = 2.74, P less than 0.02. For serum insulin, the comparative values were 65.3 muU/ml (n = 20) vs. 29.8 muU/ml (n = 11); t = 3.03, P less than 0.01. For urinary cyclic AMP, the comparative values were 0.46 mumol/m2 (n = 22) vs. 0.18 mumol/m2 (n = 10); t = 2.48, P less than 0.02. Growth hormone therapy resulted in a significant improvement in the glucose, insulin, and cyclic AMP responses to intravenous glucagon in the growth hormone deficient group of children.

Adolescent↗
PubMed1976

Nerve conduction velocity determinations in juvenile diabetes: continuing study of 190 patients.

Few prospective studies on the concomitant finding of neuropathy in juvenile diabetics exist. An ongoing study of motor and sensory nerve conduction determinations in 190 diabetic children, with sequential studies in 108 of them over an eight-year period, is the subject of this report. The incidence of neuropathy in our sample population under five years of age is neglible. In the children over five years of age, 8% had abnormal nerve conduction velocity (NCV) of the peroneal nerve, 4.5% had abnormal median motor and sensory NCV on initial study. In the sequential studies of the children over five years of age, the percentage of abnormal NCV rose from 14% to 48% as the duration of diabetes increased from one year to more than five years. It is the older juvenile diabetics with the longest duration of diabetes who would appear to have the highest incidence of neuropathy.

Adolescent↗