Biomedical subjects
W Hosemann
Publications and source records attributed to W Hosemann.
Left atrial myxoma presenting with synchronous carotid and femoral embolism.
Synchronous embolism of the right femoral and the left internal carotid arteries, occurring in a 39-year-old teacher upon physical effort, was found to be due to a left atrial myxoma. Clinical findings, electrocardiogram and chest radiographs had suggested myocarditis. The patient died of cerebral infarction. In cases of suspected myocarditis, left atrial myxoma has to be considered in the differential diagnosis. Histological examination is recommended of any material obtained by embolectomy.
[Histochemical characterization of Kupffer cells].
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Identification of G6PDH-active sinusoidal cells as Kupffer cells in the rat liver.
The aim of this study was to identify the G6PDH-active sinusoidal cells in the rat liver described by Rieder et al. (1978). Because of their number and distribution in the liver parenchyma, endothelial cells and pit cells could be excluded. Fat-storing cells were specifically marked by vital staining with vitamin A and identified by fluorescence microscopy. Kupffer cells could be detected after vital staining with carmine. Both staining methods allowed a subsequent incubation for the demonstration of G6PDH activity in the same unfixed cryostat section. Whereas more than 80% of the fluorescent particles were found outside the enzyme-positive cells, all G6PDH-active cells contained carmine particles. After counting the G6PDH-active cells, an estimation of 0.217 x 10(8) cells/g liver tissue was obtained. The results indicate that high G6PDH activity is common to all Kupffer cells, and is therefore a highly specific marker enzyme for this class of sinusoidal liver cells.
Epidemiology, pathophysiology of nasal polyposis, and spectrum of endonasal sinus surgery.
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Endonasal frontal sinusotomy in surgical management of chronic sinusitis: a critical evaluation.
Frontal sinusotomy was performed on 110 patients undergoing routine endoscopic endonasal ethmoidectomy and the minimum diameter of the frontal sinus neo-ostium was determined intraoperatively. A total of 82 patients could be subjected to follow-up and redetermination of the neo-ostium diameter 13 months later. A postoperative CT was scheduled in 62 cases. The average minimum diameter of the frontal sinus neo-ostium, measured intraoperatively, was 5.6 mm (0-11 mm). After completion of wound healing, 81% of the frontal sinuses could be explored by probing or even inspected by rigid endoscopy. The average minimum diameter of the neo-ostia determined postoperatively was 3.5 mm (0-11 mm). Patients exhibiting aspirin sensitivity or diffuse nasal polyposis showed a more pronounced scarred constriction of the frontal sinus access compared to other cases. Neo-ostia exceeding 5 mm intraoperatively were preserved with a considerably higher percentage than those with diameters of less than 5 mm. Radiologically, the fenestrated frontal sinuses frequently showed continued or even increasing mucosal congestion. No conclusive relationship was found to exist between such post-operative clouding and frontal sinus accessibility (endoscopy and/or probing) or patient complaints. The investigations confirm the safety and reliability of frontal sinusotomy in surgical management of chronic paranasal sinusitis. The mucosa of the frontal sinus often reacts to surgery in the form of persistent or even newly developing mucosal swelling to which a specific pathophysiological significance cannot always be attributed.
Video-endoscope versus endoscope for paranasal sinus surgery: influence on visual acuity and color discrimination.
Endoscopic and video-endoscopic visual acuity and color discrimination were investigated using a standard disk for testing visual acuity and a color discrimination test. A 1-chip-CCD-Camera (CCC) or 3-chip-CCD-Camera plus digital image processing (digivideo) on the endoscope and a 15 inch high resolution video monitor were used. Color discrimination was investigated by comparing the ability to sort colored disks of low chromatic saturation (desaturated Panel D-15 Test), ranging from yellow to red, under direct vision or via monitor using the same 1-CCC- and 3-CCC-system. Visual acuity deteriorated by 1.58 +/- 0.16 steps (+/- SEM) for the 1-CCC and 1.21 +/- 0.16 steps for the 3-CCC plus digivideo compared to vision through the endoscope (p < 0.001 and p < 0.001). Visual acuity was significantly better for the 3-CCC-video-endoscope compared to the 1-CCC-video-endoscope (p = 0.0045). The difference in color discrimination between the naked eye and the 1-CCC-monitor system was not significant. More mistakes were made with the 3-CCC-monitor system. The impairment of image quality with the video endoscope, which is experienced by many surgeons, is reflected in a marked loss of visual acuity in our experiments. Sharpness and contrast of the video-image are significantly enhanced by the 3-CCC plus digital image processing, compared to the 1-CCC. Color discrimination, however, was not impaired by the 1-CCC, indicating that color perception with the video-endoscope can be very good and may not contribute significantly to the loss of image quality.