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Biomedical subjects

W Hoffmann

Publications and source records attributed to W Hoffmann.

At least 289 records · Page 16Linked to original sources
PubMed1976

[Influence of a pressure agent on blood concentrations of glucose, lactate, pyruvate and free fatty acids (author's transl)].

In 34 unselected patients blood concentrations of glucose, lactate, pyruvate and free fatty acids (FFA) were determined after i.v. injection of a pressure agent containing theophylline esterified with norephedrine and theophylline esterified with norepinephrine (Akrinor) with and without beta-adrenergic blockade. After Akrinor a significant increase of FFA concentration of 32% is observed, which can be abolished by beta-receptor blocking agents. Our findings indicate that the Akrinor-induced lipolysis is mainly due to a direct sympathomimetic effect on the beta-receptors of adipose tissue. there are only slight effects on carbohydrate metabolism (decrease of pyruvate concentration, increase of lactate/pyruvate ratio) which are not influenced by beta-receptor blockade. According to our results there are important metabolic differences between Akrinor and the classical catecholamines.

Blood Glucose↗
PubMed1975

Aminopeptidases of Physarum polycephalum. Activity, isoenzyme pattern, and synthesis during differentiation.

In extracts from both growing and differentiating (spherulating) plasmodia of the true slime mold Physarum polycephalum, high aminopeptidase activities were found. The specificity of the aminopeptidases changed during differentiation with a higher relative activity towards hydrophobic NH2-terminal amino acids. This change in specificity was found to be the result of a shift in the isoenzyme spectrum during differentiation as was tested by isoelectric focusing in sucrose gradients. Three different classes of isoenzymes were found: one band which was present in both growing and differentiating cultures; two bands which were found only in growing cultures; and four bands which were detectable only in differentiating plasmodia. If cycloheximide was applied during the induction of differentiation, only one band, the one present in both types of plasmodia, was found in the isoelectric focusing. Density labeling experiments using deuterated amino acids revealed that the bands which are present in differentiated plasmodia only are synthesized de novo during this differentiation.

Aminopeptidases↗