[Syndrome of short intestine].
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Biomedical subjects
Publications and source records attributed to W Heine.
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The special procedures and techniques to develop poly-associated gnotobiotic animals in order to start large SPF colonies of small laboratory animals are discussed.
Lactose and protein absorption from breast milk and a cow's milk preparation enriched up to 7% of lactose were studied in two infants with an artificial anus applied in the ascending colon region. The concentrations of protein, lactose, glucose and galactose were measured in the fistula stools. In addition, the stools were analysed microbiologically. There were relatively high concentrations of lactose and its decomposition products and low concentrations of protein and aminonitrogen in the fistula stools when breast milk was fed. When the cow's milk formula was applied, only traces of lactose but high amounts of protein were measured. The microbiological findings are in agreement with the hypothesis that the bacterial flora of the large intestine is influenced by the lactose and protein concentrations in the intestinal content which reach the large intestine.
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This is a report on clinical and biochemical metabolic investigations performed on 8 infant and 5 adult surgical patients treated with continous infusions of "Alvesin neu". This amino acid solution produced by the "VEB Berlin-Chemie" differs from Alvesin in that it adapts the essential amino acid pattern of the whole-egg protein amino acid relation. Furthermore, the pattern of non-essential amino acids was completed in comparison to "Alvesin". All infusions of "Alvesin neu" were well tolerated. Side effects did not occur. In the course of the infusion the alpha-amino nitrogen level of blood increased slowly. Serum levels of alanine, valine, phenylalanine and methionine analyzed through the column-chromatographic method were found to be slightly or moderately increased. Proline- and glutamic acid concentrations of serum were within the normal range. Elevated levels of glycine--as observed during "Alvesin" infusion in several cases--did not occur. The mean urinary loss of alpha-amino nitrogen was 14% in the infant and 17% in the adult patients group respectively. The daily total nitrogen retention rate in the infant group was +0,390 +/- 0,72 g on an average; the corresponding value in the adult group was -5,46 +/- 5,99 g N/day.
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