Search PubMed⌕ Search

Biomedical subjects

W Grote

Publications and source records attributed to W Grote.

At least 145 records · Page 8Linked to original sources
PubMed1976

[Experimental studies to the teratogen effects of virus-induced fever (author's transl)].

Fever was induced in pregnant rabbits at the 9th day of gestation by injection of a heat inactivated virus which had not lost its pyrogenic activity. The mother rabbits were killed on the 29th day of pregnancy, the fetuses taken out and the uteri examined for resorptions. The fetuses were inspected for organ malformations macroscopically and for skeleten malformations microscopically. The results were compared with those of control animals. The rise of temperature up to a maximum 2,1 degrees C above normal temperature resulted in no higher resorption and malformation rate.

Animals↗
PubMed1976

Metabolic research in monozygotic twins with diabetes mellitus: progress report.

An intravenous and oral glucose tolerance test and an intravenous tolbutamide test have been performed in 11 MZ twin pairs, discordant for diabetes mellitus. Blood sugar, immunoreactive insulin, and free fatty acids were determined. The research aimed at finding out whether prediabetic subjects may show any characteristic parameter which could be suggestive of the hereditary disposition. Three MZ twins of juvenile diabetics showed a normal blood glucose, immunoreactive insulin, and free fatty acids during the glucose and tolbutamide loads within a maximum of 10 years observation.

Adolescent↗
PubMed1975

The relation between intracrainal pressure, mean arterial pressure and cerebral blood flow in patients with severe head injury.

UNLABELLED: In patients with severe head injuries ICP, MAP and CBF were measured continuously. In most patients there was a positive vasopressor response to increasing ICP, but the ICP/MAP ratio varied considerably in individual cases. CBF was diminished either by increasing ICP or by decreasing MAP. This effect was more marked with ICP above 40 mm Hg or MAP below 110 mm Hg. In terminal stages there was often a negative MAP/ICP ratio accompanied by massive cerebral hyperaemia. Key words: Severe head injury--intracranial pressure--mean arterial pressure--cerebral blood flow--cerebral perfusion pressure--critical limit of ICP and CBF. ABBREVIATIONS: ICP equals intracranial pressure (mm Hg); CBF, Flow equals cerebral blood flow (ml/min); MAP equals mean arterial pressure (mm Hg); CPP equals cerebral perfusion pressure (mm Hg) (difference between MAP and ICP); BP equals blood pressure.

Blood Pressure↗
PubMed1975

[Complications of anterior cervical fusion operations].

The authors describe the technique of operation and then report about 15 intra- and post-operative complications in 360 anterior cervical fusions in 307 patients who suffered from cervical disc lesions. The complication rate was 4.16%. Apart from one case of complete but clinically reasonably well compensated recurrent paresis, all complications healed without permanent deficit. The differential diagnosis, prophylaxis and therapy of these specific operative complications are discussed.

Adolescent↗
PubMed1975

New possibilities of controlled hypotension in neurosurgery.

The position of controlled hypotension in neurosurgery is reviewed including both the new and old techniques and the drugs used. A special emphasis is placed on our use of sodium Nitroprusside which allows short lived, but very significant lowering of the blood pressure. Using this technique it was possbile in three cases where rebleeding of the aneurysm occurred at operation and in a further six cases of considerable arterial haemorrhage, to, "dry" the field of operation i.e. reduce the bleeding to such an extent that satisfactory orientation and quick and accurate handling of the emergency could be achieved.

Adult↗
PubMed1975

Diagnosis and treatment of bilateral traumatic carotid-cavernous sinus fistulae.

The authors report the diagnosis and successful treatment of a case of traumatic bilateral carotid-cavernous sinus fistula. Direct tamponade of the fistula with a Fogarty catheter and ligation of all cervical carotid vessels was carried out on the left side following ligation on the right side of the common carotid, the internal carotid extra- and intracranially, and of the external carotid artery. The pre-requisite for this procedure was the development of a functional collateral circulation via the posterior communicating arteries from the basilar system. The 18 months follow-up report and the rare reports in the world literature on the operative techniques and the results of treatment of similar cases are discussed.

Adult↗
PubMed1975

[Long-Term Results of Surgical Treatment of Spinal Tumours in Children and Adolescents].

Catamneses of children up to the age of 16, operated on spinal tumours, are reported. Spinal tumours of this age account for about 15% of the total (all ages). There are about 50% intradural and 50% extradural tumours. The most frequent extradural tumours are sarcomas, followed by lipomas and dysontogenetic tumours like teratomas. Intradural tumours consist of intramedullary and extramedullary ones, about 50% each. Intramedullary tumours are gliomas, extramedullary ones may be neurinomas, meningeomas and vascular tumours. Time from onset of first diffuse symptoms up to clinical diagnosis depends on growth tendency of the tumour as well as on its localization. Hence, case history in cases of intramedullary gliomas usually covers two years, of sarcomas only a couple of months. In half of the cases, pain was the first symptom, followed by disturbed motor function. In more than 50% of the cases, complete restoration or significant improvement could be achieved by surgery. In the remaining half, there was either no change or even deterioration of the disturbed function. It seems justified to replace the former pessimistic attitude towards therapy of spinal tumours in childhood by a discret optimism. If in addition other spinal diseases like disk herniation are taken into account, prognosis is even more favourable.

Adolescent↗
PubMed1975

[Animal experiments on the "dysionic genesis of intrauterine malformations"].

Pregnant rabbits were injected 12 mg 4-chloro-5-sulfamoyl-N-furfuryl-anthranilic acid (furosemide)/kg body weight from the first to the tenth day of pregnancy (o.p.). The serum concentrations of sodium, potassium and calcium were determined on the 1st, 9th and 14th day o.p. The mother rabbits were killed on the 29th day of o.p., their foetuses were removed and the mucous membrane of the uterus was inspected for resorption sites. The foetuses were examined, the skeletons were stained and studied under the microscope. The results of the treated rabbits were compared with those of the control rabbits. The sodium, potassium and calcium concentrations of the treated rabbits were not lowered significantly. The haematocrite did not change during or after the treatment. The mothers gained weight continuously. The rates of resorption and malformation of the treated group were slightly raised.

Abnormalities, Drug-Induced↗