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Biomedical subjects

W Grimm

Publications and source records attributed to W Grimm.

At least 163 records · Page 9Linked to original sources
PubMedDate not supplied

[Mediastinal teratocarcinoma and hypophyseal stalk germinoma in a patient with Klinefelter syndrome].

A 8 1/2 year old boy is reported, who was admitted because of rapid growth and premature development of pubic hair. Pseudopubertas praecox was diagnosed, caused by a beta-HCG producing mediastinal teratocarcinoma. The patient also had a pituitary germinoma. His karyotype was 47, XXY. While the association of Klinefelter's syndrome and breast cancer is well known, only recently an increased incidence of mediastinal germ cell tumors in this syndrome has been established, which again is demonstrated in this case report.

Adolescent↗
PubMedDate not supplied

[Treatment of marked gynecomastia in puberty with tamoxifen].

Based on the good results of another author 10 boys with marked pubertal gynecomastia were treated with the antioestrogen Tamoxifen (Nolvadex) at a dose of 20-40 mg/d orally for 2-12 months. In most cases the gynecomastia decreased totally, only two patients experienced palpable subareolar glandular tissue at the end of therapy. Side effects were not noted. During therapy levels of estradiol and testosteron increased, with a more pronounced elevation of estradiol. Basal values of LH and FSH remained nearly unchanged, but LH showed an increased response to LH-RH, which could be explained by the antioestrogenic effect of Tamoxifen at the hypothalamic level. The reduction of breast size in spite of increased estradiol levels on the other hand, suggests that the mean therapeutic effect of tamoxifen is through estrogen receptor blockade of breast tissue.

Adolescent↗