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Biomedical subjects

W Grimm

Publications and source records attributed to W Grimm.

At least 145 records · Page 8Linked to original sources
PubMed1979

[A comparative study of the reflective and apperceptive refractions (author's transl)].

Reflective (objective) refraction differs basically from apperceptive (subjective) refraction in that it excludes conscious seeing from the measuring procedure. As a result limits can be established for the subjective acceptability of refraction values with automatic or manual refractometers. In a comparative study of 50 cases the correction values obtained with the manual refractometer PR 50 (Rodenstock) and the automatic refractometers Dioptron (Coherent Radiation) and Auto-refractor 6600 (Acuity Systems) were compared with the results of conventional subjective refraction. Criterion for this comparison was the visual acuity achieved with the correction values. In 55% of the cases the same, in some cases even better visual acuity was achieved than with subjective refraction. In the other 45% a direct comparison of the reflective and the subjective refraction values shows which component (sphere, cylinder) of the refractometer correction value leads to a lower visual acuity.

Adult↗
PubMed1978

[Experimental studies on the effect of pyloroplasty on gastric emptying, serum gastrin and duodenogastric reflux in selective proximal vagotomy (SPV)].

The influence of selective proximal vagotomy (SPV) and of an additional pyloroplasty (Heineke-Mikulicz) on gastric emptying, acid and gastrin secretion, and duodenogastric reflux was examined experimentally. After SPV, gastric emptying of fluids and a solid meal was significantly faster than before surgery. An additional pyloroplasty did not influence gastric emptying time significantly. Gastrin secretion after stimulation with a protein-rich meal increased significantly after SPV and did not change much after pyloroplasty was added. It can be concluded that increased gastrin secretion after SPV is not a result of delayed emptying. Pentagastrin-stimulated acid secretion was reduced by 70% after SPV and after additional pyloroplasty as well. The results show that reduced acid secretion after SPV causes the rise in serum gastrin levels. After SPV no duodenogastric reflux occurred. An additional pyloroplasty led to a significant rise of bromsulphaleine used as a marker for bile in gastric aspirate. Obviously destruction of the pylorus leads to a loss of its antireflux function. This leads to an antral gastritis which after 3 months is of chronic-atrophic type. A stimulation of gastrin output by bile could not be demonstrated. It can be concluded that after SPV gastric emptying is not delayed. A pyloroplasty does not affect gastrin release and acid secretion. Drainage procedures together with SPV should be avoided to prevent duodenogastric reflux and antral gastritis.

Duodenal Diseases↗
PubMed1978

[Palliative radiotherapy with Strontium-89 in case of extended formation of skeleton metastases (author's transl)].

In order to allay pains or make them cease, fifteen patients with extended tumors and generalized formation of skeleton metastases were submitted in 1976 to an internal palliative radiotherapy. They received between 0.8 and 2.7 mCi of Sr-89, five patients were treated again after four to five months because the pains had reappeared. The results were relatively good. Two patients showed a prompt effect and were completely free of pains within 48 hours, three patients did not present any demonstrable effect. The analgetic effect remained from four days to four months. Due to the utilization of the pure beta emitter Sr-89, the radiation doses measured in the patients after the application are relatively small: after the application they amount at most to 0.5 mR/h in a distance of 1 m.

Adult↗
PubMed1977

The effect of nacom (L-dopa and L-carbidopa) on growth hormone secretion in 75 patients with short stature.

The stimulatory effect of Nacom (250 mg L-Dopa and 25 mg L-Carbidopa) on the HGH secretion was evaluated in 75 short stature patients. The number of blood samples was restricted to only three (0, 45 and 90 min). 63 patients reached adequate HGH concentrations after the ingestion of 1 tablet Nacom (84%). Somatotropin levels increased from 2.08 (Sx 0.28) to a maximal HGH value of 14.22 (Sx 0.87) ng/ml. When the stimulatory effect of Nacom was compared with the standard method of arginine infusion in children with normal stature the arginine test was not superior to the Nacom-test. The Nacom-test appears to be a simple and reliable screening method for HGH deficiency, particularly in outpatients.

Adolescent↗
PubMed1976

[HGH secretion after oral application of L-dopa and L-carbidopa (author's transl)].

The stimulatory effect of L-Dopa and L-Carbidopa (Nacom) on HGH secretion was determined in 12 children of normal height aged from 6 to 14 years. Each child received a standard dose of 250 mg L-Dopa and 25 mg L-Carbidopa p.o. HGH concentration in the serum was determined at standard intervals. All subjects showed a sufficient increase of HGH. The mean value was 19.6 ng/ml. According to the maximum values of the HGH concentration the sample can be divided into two groups; the first group reached the highest values after 20--40 min, the second one after 60--90 min. On evaluation of the curve of the mean values it appears that 2 blood samples taken 40 and 90 min after the ingestion of L-Dopa and L-Carbidopa are sufficient in order to exclude HGH deficiency. The theoretical background for HGH secretion after stimulation by L-Dopa and L-Carbidopa is discussed.

Administration, Oral↗
PubMed1975

[Sequential scintigraphy of four different 99mTc human albumen preparations used for lung scanning].

The biological behaviour of four 99mTc-marked human albumen preparations, prepared by different methods, were studied by serial scintigraphy and excretion measurements. Three preparations consisted of particles of irregular albumen macroaggregates, the fourth was in the form of spherical albumen particles (microspheres). Forty-five patients with various pulmonary abnormalities were examined. The following parameters were used for comparison: half-life of pulmonary activity, changes in activity in liver and spleen as a measure for the formation of Tc-containing particle fragments, uptake in the thyroid and stomach and urinary excretion as an indication of the stability of the nucleid fixation. Despite marked differences in their biological behaviour, all four substances provide comparable information and lack of toxicity and are suitable for lung scintigraphy. Because of the rapid initial decline in activity in the lung, microspheres are more suitable for use with a gamma camera, whereas the other three preparations, in view of their long persistence in the lung can be conveniently used for the slower examinations with a conventional scanner.

Colloids↗
PubMed1975

[The distribution of Sn2+ after application as a complex (author's transl)].

On animal experiments was shown that Sn2+ after i.v. application with 113Sn as radioactiv indicator was deposited in the skeleton. Experiments were done with citrat-, tartrat-, pyrophosphat-, phosphat- and Sn2+/HCl-complexes. The importance of the results for the use of Sn2+-solutions in Nuclear Medicine for men are discussed.

Animals↗
PubMed1975

[99mTc-iron complex for demonstrating reflux without the use of a catheter (author's transl)].

99mTc-iron complex was used in 35 patients (20 adults and 15 children) in an investigation into ureteric reflux without using a catheter. The results were compared with the findings on micturating cysto-urethrography. Agreement in the findings was observed in 56 of the 69 kidneys examined. In only four kidneys, showing reflux radiologically, was this not observed on the isotope examination; in view of the low radiation dose, the catheter-free isotope method can be recommended as the most suitable investigation. The need for serial investigations or contrast allergies are important indications for using this method. The relatively high frequency with which reflux shown by the isotope method could not be confirmed radiologically (nine kidneys) indicates that the isotope is more sensitive than the radiological investigation.

Adolescent↗