Peripheral blood leucocytes and mononuclear cell subpopulations in testicular tumour patients - a preliminary study.
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Biomedical subjects
Publications and source records attributed to W Duncan.
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Aryl-hydrocarbon-hydroxylase (A.H.H.) inducibility has been studied in the peripheral-blood lymphocytes of patients with squamous-cell lung cancer, of patients with cancer at other sites, and of controls matched for age, sex, social class, and smoking habits. The proportion of high inducers was significantly greater among patients with lung cancer (but not patients with other cancers) than among controls, which suggests that, besides smoking, a constitutional factor may be involved in the pathogenesis of lung cancer.
Bipedal lymphography and intravenous urography were carried out in 44 patients in an attempt to define the role of these procedures in the assessment of the patient with carcinoma of the bladder. Evidence of lymphatic involvement, even though unsupported by histological proof and a major abnormality on urography, conferred a worse prognosis than if these examinations were thought to be normal. Implications for therapy are considered.
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A suite of Fortran programs for carrying out the various dose computational aspects of radiotherapy has been developed on an enhanced RAD8 computing system. The hardward configuration of the computer is described and the main features of the programs in the suite are discussed. The include: (a) beam data input systems for use with linear accelerators and cobalt units; (b) static and rotational teletherapy planning, with computer optimization in the static planning; (c) irregular field calculations with isodose visualization; (d) interstitial calculations including routines which will reconstruct a radium needle implant in three dimensions in addition to presenting the isodose distribution in any desired plane. The problems of implementing the programs on another computer system are discussed.
The age-correlated survival rates for 982 women treated for localised breast cancer were analysed retrospectively. Analysis by size of the primary cancer showed that those with smaller cancers had a significantly higher survival rate and a significantly reduced probability of dying of cancer. Cured groups of patients were identified for all but those with the smallest tumours--2.0 cm in diameter or smaller. A long period of follow-up (to 25 years) is necessary to establish the presence of a large cured group in such cases.
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