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Biomedical subjects

W Cendrowski

Publications and source records attributed to W Cendrowski.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

A case of multiple sclerosis associated with defective neuromuscular transmission.

A 38-year-old woman developed relapsing disseminated sclerosis associated with myasthenic syndrome. The cerebrospinal fluid showed 12 lymphocytes per 1 mul and paretic colloidal curve. The serum contained antibody against smooth muscle antigen (titre 1 : 10) but no antibody against nuclear antigen or VDRL antigen. Repetitive stimulation of the right ulnar nerve at 35 c/sec. demonstrated typical decrements between 70 and 72%. The prostigmine test showed significant diminishing of decrements. The possible immunopathological mechanism of myasthenic syndrome in multiple sclerosis was briefly discussed.

Adult↗
PubMedDate not supplied

[Nuchal-paretic sign in multiple sclerosis].

A 43-year-old patient with clinically established diagnosis of multiple sclerosis had the nuchal-paretic sign. Neck flexion caused reversible deterioration of gait and increased the weakness of the right lower extremity. Although the sign is not pathognomonic for multiple sclerosis it is a peculiar pyramidal sign suggesting demyelination especially in the cervical part of the spine. Mechanical stretching of the demyelination plaques in the cervical spine reduces probably the density of the action current generated at the nodes of the demyelinated fibres.

Adult↗
PubMedDate not supplied

[Lipid peroxides in the sera of patients with multiple sclerosis].

Serum lipid peroxides (LPX) were determined in 24 patients with multiple sclerosis and in 30 healthy controls. Patients with relapses or chronic progression had significantly higher serum LPX level than healthy controls: mean 3.09 +/- 0.15 nmol/ml versus 2.30 nmol/ml, p less than 0.01. Relapsing-remitting patients showed slightly higher LPX level than slowly progressive patients. It is supposed that lipid peroxides are unspecific mediators of the inflammatory reaction in multiple sclerosis.

Adult↗
PubMedDate not supplied

[The risk of multiple sclerosis development in patients with idiopathic optic neuritis: prognosis and other problems].

The percentage of patients with idiopathic optic neuritis (ION) developing multiple sclerosis (MS) was higher in young females who had recurrent ION, especially during 4 years since the first inflammatory attack. Clinical features of ION had no prognostic value. Patients with ION developed also more frequently MS if paraclinical findings showed the occurrence of DR2, DR3, DQw1 and/or DPw4, increased CSF IgG index, CSF oligoclonal IgG, asymptomatic lesions in NMR brain images, and subclinical abnormalities in visual, brainstem auditory, somatosensory evoked potentials. The author discusses the problem whether high risk patients with ION should be given antiviral and immunomodulatory drugs which could prevent or delay the clinical onset of MS.

Adult↗
PubMedDate not supplied

[Symptomatology of infrequent visual disturbances in multiple sclerosis patients].

Two cases of clinically certain multiple sclerosis were observed in whom rather infrequently occurring symptoms of damage to the visual pathways were noted. In one case during right-sided optic neuritis cyanopsia developed, followed after five months by left-sided alternatively darkening and lightening of vision. In another case with bilateral retrobulbar optic neuritis attacks of fading-out vision appeared when the patient fixed an object. Two years later the patient had episodes of chloropsia.

Adolescent↗
PubMedDate not supplied

[Serum levels of lipid peroxides in alcoholics].

Serum lipid peroxidases (LPx) concentration was assayed in the following groups: 25 patients with diagnosis of acute alcohol intoxication, 20 patients during alcohol abstinence and 30 healthy control individuals. In 25 patients the assessments were carried out twice: before and on the 3-7 day of detoxification. The serum LPx had been significantly higher in all patients during the acute intoxication period (4.33 +/- 0.20 nmol/l; p less than 0.01). In 38% of them the LPx concentration was falling down after detoxication. There were no difference in LPx concentration between the group of abstinents and the healthy controls. The results point to dependence between clinical state of alcoholics and serum LPx level.

Adult↗
PubMedDate not supplied

[Gamma globulin subfractions and immunoglobulin G in the cerebrospinal fluid of patients with multiple sclerosis, subacute sclerosing panencephalitis and other diseases of the nervous system].

CSF samples were obtained from 22 patients with multiple sclerosis, 14 patients with subacute sclerosis panencephalitis, and 10 with neuroses or headaches. Most samples were investigated simultaneously by a sensitive method of electrophoresis in polyacrylamide gel (PE) and radial immunodiffusion (RID). The absolute IgG concentration was in multiple sclerosis 6.8 +/- 3.3 mg/100 ml, and in SSPE 21.4 +/- 16.8 mg/100 ml and it was higher than in control subjects (p less than 0.01). In 84% of MS patients the Bauer index (IgG: total protein) was raised, 72% had relatively raised subfractions gamma 2-gamma 3 in PE, 64% had higher absolute concentration of GG (0.045 g/l or more) and 63% had increased proportion of one of gammaglobulin subfractions (over 4%). Of positive diagnostic importance was a rise of the IgG: total protein index, since 7 patients with SM (31%) with normal per cent gammaglobulin level (less than or equal to 13%) had an evident rise of this index. Raised value of the index IgG: total protein (greater than or equal to 10%) was observed also in 100% of SSPE cases, while in 92% the proportional value of one of gamma globulin subfractions was increased (over 4%), in 92% the subfractions gamma 3-gamma 4 were increased, in 85-86% of patients the relative (over 13%) and absolute (0.045 g/l or more) levels of gammaglobulins were increased. The index beta/gamma in MS and SSPE was 0.85 and 0.57 respectively, and was significantly lower than in patients with headaches. The authors discuss the diagnostic value of these findings.

Epilepsy↗
PubMedDate not supplied

Multiple sclerosis and diseases of autoimmune or related origin.

Medical records of three series of clinically probable multiple sclerosis (MS), consisting of 54, 180 and 51 patients, were screened for past or present coexisted disorders in which autoimmune mechanisms are believed to play a role. The comparison showed that idiopathic optic neuritis and chronic retinitis juxtapapillaris were significantly more frequent among MS patients than in control populations. One case of severe periphlebitis retinae and another one of myasthenia gravis-like syndrome were also encountered in MS population but lacked comparable control groups. This is consistent with data suggesting that MS was associated so far with four autoimmune disorders. They either possibly shared with MS common etiopathogenesis (idiopathic optic neuritis, peripheral demyelinating neuropathy), formed extending component of the perivenous inflammatory process (periphlebitis retinae) or belonged to the HLA linkage group (hypocomplementaemia C3).

Adult↗
PubMedDate not supplied

[Dyslexia of digits and numbers in multiple sclerosis].

In a 32-year-old man with remitting-progressive multiple sclerosis a right-side hemiparesis and alexia of digits of numbers developed during an exacerbation. While reading aloud the patient changed digits, left them out or transposed. No changes were observed in reading of letters, words and no agraphia was present. Alexia persisted for about one month. The location of alexia in the occipital lobe and its association pathways with the left parietal lobe are discussed.

Adult↗
PubMedDate not supplied

[Dantrium in the treatment of increased muscle tonus in patients with multiple sclerosis].

In 19 patients with multiple sclerosis and 1 with subacute sclerosing panencephalitis the mean increase in muscle tonus was found to be 3.1 (range 1--4 according to Burke-Ashwort). In 10 controls with multiple sclerosis the mean spasticity was 2.4. Dantrium was given in doses up to 800 mg for 14--16 days and it caused a greater reduction of spasticity than placebo (p less than 0.05). In 12 patients (60%) varying degrees of muscle tonus reduction was observed. In 11 patients the efect of Dantrium was compared with that of other drugs (Clonazepam, Tetradiazepam, Carisoprodol and Lyoresal). In 6 cases Dantrium was a more effective drug than other muscle relaxants and in 5 cases no difference was observed or other drugs were superior to Dantrium.

Adult↗