Search PubMed⌕ Search

Biomedical subjects

W Cendrowski

Publications and source records attributed to W Cendrowski.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

Elevated parainfluenza virus type 1 antibody in patients with subacute sclerosing panencephalitis.

Parainfluenza virus hemagglutination inhibition (HI) antibodies were determined 3 times in the sera of 9 patients with subacute sclerosiing panencephalitis (SSPE) and 20 healthy controls matched for age and place of residence. Serum antibody against parainfluenza virus type 1 was significantly elevated in SSPE patients as compared with controls, whereas antibodies against type 2 and 3 were found to be in normal ranges. Higher titres of parainfluenza virus type 1 antibody might depend on: (1) dual viral infection, (2) cross-reaction between antigens of SSPE virus and parainfluenza virus type 1, and (3) non-specific activation of latent virus type 1 genome. The latter explanation seems to be particularly interesting since the parainfluenza type 1 antibody titres remained constant despite the clinical progression. This finding is comparable to the elevated titres against Epstein-Barr virus of adenovirus which have been found occasionally in this disease.

Adolescent↗
PubMedDate not supplied

[Connection between severe perivenous retinitis with retinovitreal hemorrhage and disseminated sclerosis].

In a 49-year-old man with temporal pallor of the left optic nerve papilla and increasing spastic paraparesis and with slight lymphocytosis in the cerebrospinal fluid perivenous retinitis was diagnosed. The peripheral retinal veins were covered with characteristic white sheaths, focal formation of new blood vessels, retinal microscopic haemorrhages and residues after vitreal haemorrhage were found. The authors discuss the possibility of a connection between disseminated sclerosis and perivenous retinitis and their possible common aetiology.

Humans↗
PubMedDate not supplied

[Multiple sclerosis in the year 2000: advances in the treatment with interferon beta-1b].

The decline of millennium brings forward new challenges in therapeutic immunomodulation of relapsing-remittent multiple sclerosis (RR MS). Interferon beta-1b (Betaferon) belongs to expanding family of soluble cytokines which are capable to modify beneficially cellular immunity in RR MS. IFN beta-1b is indicated for young or middle-aged, ambulant patients with RR MS who have frequent relapses, "aggressive" brain lesions in magnetic resonance imaging and higher levels of pro-inflammatory cytokines. Betaferon reduced in people with RR MS mean annual rate and severity of relapses (34% and 49%) and lengthened median time to second relapse (to 295 days). IFN beta-1b also increased the number of relapse-free patients (31%). Although the drug diminishes weakly progression and activity (disability) it might improve slightly participation (handicap) and quality of life. The course of treatment, withdrawals from the trials, side-effects and the occurrence of neutralizing antibodies to IFN beta-1b are concisely described. Combination of IFN beta-1b with other immunotherapeutic drugs needs further clinical trials.

Acetaminophen↗
PubMedDate not supplied

[Micropsia in multiple sclerosis].

Micropsia is described in a case of remitting multiple sclerosis with left optic neuritis and spastic paraparesis. The damage to small axons in the optic nerve conducting spatial impulses from temporal and lower segments of retina might be responsible for the occurrence of transient micropsia.

Adult↗
PubMedDate not supplied

[Evaluation of cerebrospinal fluid proteins in patients with subacute sclerosing panencephalitis (SSPE)].

CSF proteins of 62 patients with SSPE aged 6 to 26 years were analysed by polyacrylamide gel electrophoresis. The total IgG concentration in the CSF was increased to 16.8 +/- 10 mg/dl and the IgG index was raised to from 2.7 +/- 0.5 to 3.6 +/- 3.0. All SSPE patients had pathological subfractions gamma 4 and gamma 5. The per cent proportion of the gamma 1 subfraction was raised only in the youngest patients. A tendency was observed for higher values of the prealbumin:albumin index and the prealbumin: transferrin index. The youngest SSPE patients had a tendency for greater total protein concentration, lower prealbumin concentration, and highest IgG index values (3.6 +/- 3.0). In early disease period a tendency was noted for higher concentration of total protein, higher total IgG level and higher IgG index. These results suggest that SSPE patients have a constant stimulation of B-cells and variable increase of blood-brain barrier permeability.

Adolescent↗