Biomedical subjects

W Carol

Publications and source records attributed to W Carol.

At least 73 records · Page 4Linked to original sources

PubMed1975

[Use of the depot estrogen ethinylestradiol sulfate in the therapy of menopausal syndrome].

Ethinylestradiol sulfonate is a newly developed orally effective derivate of ethinylestradiol with depot properties produced by "Jenapharm"-GDR. This depot estrogen has been proved for its usefullness in treating menopausal syndrom. A modified Kupperman-index had been used to check the therapeutic results. The effects concerning the endometrium were examined in postmenopausal women that atrophic character of endometrium had been ensured before. Ethinylestradiol sulfonate was applicated in the following dosages: 0,015 mg/day; 0,25 mg/week; 0,5 mg/week; 1,0 mg/week; 3 mg/month. The treatment with 0,25 mg/week over a period of 4 up to 6 weeks proved to be possible and effective if we take into account the endometrial reaction and the danger of bleeding. After the removal of the uterus higher dosages can be given. Up to a dose of 1 mg/week there were not to be seen subjective side effects. Ethinylestradiol sulfonate was compared with other oral estrogens.

Aged↗

PubMed1975

[Demonstration of harmlessness of hormonal contraceptives for subsequent pregnancies].

A possible negative influence of anticonceptional steroids on various stages of reproduction is discussed. Theoretically an action of antifertility drugs on mutagenesis, the segmentation period, embryogenesis, foetogenesis or somatic and sexual development behaviour is conceivable. In accordance with the results reported by other authors, our own statistical data yield no increase in the frequency of infants with congenital malformations or with chromosomal anomalies. Nevertheless, careful prospective studies should be undertaken.

Abnormalities, Drug-Induced↗

PubMed1975

[Radioimmunologic studies on serum gonadotropic hormones during oral contraception].

In 10 women serum FSH- and LH-concentrations (radioimmunoassay) were measured daily throughout a complete cycle. 2 patients exhibited untreated biphasic menstrual cycles. 2 women were under the treatment of a combined estrogen - progestagen preparation, 1 woman was taking a sequential preparation, and 5 patients were treated with a weekly dose of a recently developed depot - estrogen (ethinylestradiolsulfonate). While the untreated women showed typical serum FSH-and LH-patterns characteristic of the biphasic menstrual cycle, patients on combined therapy were found to have a continuous low FSH- and LH-level except in the postmenstrual phase of the cycle, in which the values were slightly elevated. Serum-FSH-concentration in the woman on the sequential preparation remained constant throughout the treatment peroid, while serum LH-pattern showed multiple peaks. In the same manner, serum LH-patterns in women on the weekly depot- estrogen regimen were characterized by nearly regularly appearing LH-peaks, which seemed to be correlated with the estrogen intake. The cause and clinical significance of these findings are discussed.

Contraceptives, Oral↗

PubMed1975

[Position and significance of gynecologic laparoscopy].

Over the last 1 1/2 years diagnostic laparoscopy has been performed in 135 cases and laparoscopic tubal cauterization carried out in 15 patients. Indications and the diagnostic Value of the gynecological laparoscopy are discussed. In agreement with other authors, laparoscopy is found to have a definite place for the diagnosis of the following gynecological disorders and complaints: 1. Examination of fallopian tubes in cases of infertility, diagnosis of malformations of the genital organs and of grave functional disorders of the ovaries; 2. Possible ectopic pregnancy; 3. Differential diagnosis of pelvic mass; 4. Evaluation of chronic pelvic pain; 5. Differential diagnosis of acute diseases of pelvic and lower abdominal organs. Histological examinations of coagulated human fallopian tubes yielded information on the mechanism of action of this modern method of sterilization.

Diagnosis, Differential↗

PubMed1974