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Biomedical subjects

W Carol

Publications and source records attributed to W Carol.

At least 55 records · Page 3Linked to original sources
PubMed1979

[Experience with the anti-androgen cyproterone acetate in the management of hirsutism].

Use of the antiandrogen cyproterone acetate in the treatment of hirsutism.--25 women with hirsutism or hypertrichosis faciei were subject to a "reverse sequential therapy" with cyproterone acetate (Hammerstein's regimen) for 1 to 3 years. In 8 patients, a limited, in 14 patients a satisfactory and in one woman a good result could be recorded. Cycle irregularities and subjective side effects were within a tolerable range. Studies of the hair pattern in 15 patients revealed a higher telogen rate as well as increased diameters of the hair stalks, compared with controls, in the temporal region of the head. These alterations disappeared in the course of the treatment. In the parietal region of the head no significant differences of the hair pattern were found in comparison with the controls and during application of the steroids.

Cyproterone↗
PubMed1979

[Hormonal contraception (author's transl)].

Hormonal contraceptives will continue to be used for some time to come as the safest means by which to prevent pregnancy. This is the background against which an account is given of the forms of hormonal contraception, their safety, selection of preparations, prescription for young people, side-effects, contra-indication to prescription, and indication for discontinuation.--In the context of side-effects, particular reference is made to the effects of steroids upon fat, carbohydrate, and protein metabolism, the cardiovascular system, and early pregnancy.

Cardiovascular Diseases↗
PubMed1978

Influence of hormonal contraceptives on the pituitary response to LH/FSH-releasing hormone.

In the pre-ovulatory phase the absolute and relative LH increase was much greater than during the luteal phase and less pronounced in the early follicular phase of the normal cycle. FSH release was affected only during the pre-ovulatory period, where a retarded, 3- or 4-fold increase compared to basal levels was recorded. In the women taking oral contraceptives of the conventional type the first LH-RH test showed gonadotropin responses similar to those obtained during the luteal phase of the controls. The second test brought a significantly lower LH response, suggesting an increasing exogenous steroid inhibition at the pituitary level in the course of the therapeutic cycle. This inhibition seems to be reversed during the monthly tablet-free interval. A particularly small and retarded gonadotropin response was observed in patients taking Deposiston. These results are discussed as to their clinical significance.

Female↗
PubMed1978

[The menstrual cycle in adolescents].

Data concerning onset and development of menstrual function were received by questionnaire from 740 girls attending the 10th classes of all schools in the city and the county of Jena. Menarche occurred at a mean age of 13 years and 3 months. with a standard deviation of 9.6 months. 6 girls (0,8%) had not yet observed their first bleeding at the time of the investigation. In the group of pupils studied the cycle function became regular at a mean age of 13.7 years including a standard range of 1.2 years. 396 girls observed regular bleeding intervals from the beginning of their menstrual function. 185 after a one year period of irregularity. The normal length of the menstrual bleeding ranging from 3 to 7 days was observed by 89.4% of the girls within the last 12 months prior to the investigation, a regular strength of the bleeding was reported by 82.4% of the adolescents. 39.4% of the girls affirmed the occurrence of primary dysmenorrhoea. For this reason 10 pupils regularly missed the school lessons, while 124 adolescents felt unable to take part on their lessons occasionally. Among the indications leading to gynecological examination or treatment hormonal contraception in 17 cases and artificial abortion in 4 cases are particularly worth mentioning.

Adolescent↗
PubMed1978

[Experiences with clomiphene therapy of endocrine sterility].

Two hundred seventy-three infertile women with disturbances of the menstrual cycle were treated with clomiphene citrate a level of 50 or 100 mg daily for 5 days, or even--in cases of therapeutic failure--of 150 or 200 mg daily. According to the experiences of other authors the results indicate that conception can be obtained in a rate between 35 and 40%. The frequent occurence of additional factors diminishing fertility, however, reduces this relatively favorable pregnancy rate to a level of 30% under the conditions of practice. Patients with ovulatory failures, secondary amenorrhoe associated with sufficient endogenic estrogen secretion, and luteal insufficiencies respond most favorably to clomiphene citrate. If the preovulatory cervical mucus reaction is missed, the additional application of an estrogen preparation, in cases of repeated luteal phase defects the combination of clomiphene with HCG is recommended.

Amenorrhea↗
PubMed1978

[Laurence-Moon-Bardet-Biedl syndrome and endometrial carcinoma].

Report on a classical Laurence-Moon-Bardet-Biedl-syndrome (LMBB-Syndrome). After a 9 (to 10) year-period of irregular bleedings caused by proved monophasic menstrual cycles and Stein-Leventhal-syndrome an endometrial adenocarcinoma arose in the 23 old patient. The possible carcinogenesis by virtue of an extraglandular oestrogen-(oestron-) production is discussed. The frequently observed nephropathy is often a decisive factor in morbidity and letyality of the LMBB-syndrome.

Adenocarcinoma↗
PubMed1978

[Effect of oral contraceptives on the psyche and on sexuality].

The problem of whether or not oral contraceptives affect the psychic function of the female is still controversal. The purpose of the present investigation was to study the occurrence of psychic and sexual effects in women taking either Ovosiston (mestranol 0,08 mg + chlormadinone acetate 2, 0 mg) or Non-Ovlon (ethinylestradiol 0,05 mg + norethisterone acetate 1,0 mg). 186 somatically healthy women were subject to two interviews, immediately before the start of therapy and six months after it. Most of the patients recorded distinctly alterations of their mood, their initiative, their elemental desires such as appetite, sleep, need of warmth, and their sexual behaviour. 73 of them noted a change in their emotional pattern, which was positive in 34 and negative in 39 cases. 99 women reported changes in their elemental desires. 136 patients exhibited alterations of their sexual behaviour, which were assessed as an improvement or impairment in 108 and 28 cases, respectively. There is a statistically significant correlation between the impairment of sexual function and the incidence of other untoward side effects. On the other hand, negative suggestion by poor experience of other women on by the influence of mass media seems to play a minor role in producing changes of sexual behaviour. There is, however, a clearcut relationship between negative suggestion and the incidence of unfavourable emotional alterations. The findings are discussed with reference to their clinical significance.

Adult↗
PubMed1977

[Long-term effect of hormonal contraceptives on the behavior of serum lipids].

In order to check the long-term effects of oral contraceptives used in the GDR on certain serum-lipid-fractions, triglycerides, phospholipids, total and free cholesterol, and beta-lipoproteins were determined in four groups of 15 women each, taking the contraceptive preparations Ovosiston, Nonovlon, Gravistat, and Deposiston. Determinations were carried out before and following 3, 6, 12, and 18 month of drug administration. Statistically significant increases of triglycerides occurred under the combined preparations, of phospholipids under Ovosiston and Deposiston and of the beta-lipoproteins under Ovosiston and Gravistat. Total cholesterol showed a slight decrease under all preparations tested. At present the prognostic significance of these slight alterations of serum-lipid-concentrations cannot be estimated completely.

Adult↗
PubMed1977

[Structure and ultrastructure of the endometrium with the depot contraceptive Depositon].

Endometrium was investigated histologically in 55 fertile women and by electron-microscope in 6 women under the influence of Deposiston (Jenapharm), a sequential contraceptive containing a long acting oestrogen--ethinyloestradiolsulfonate. The drug was administered orally in 1 mg doses on the 5., 12. and 19. day of each cycle. To achieve proper withdrawal bleeding a single oral dose of 10 mg norethisteronacetate was given on the 26. day of the cycle. Whereas Sequenz- Ovosiston (Jenapharm), a "classical" sequential preparation causes only insignificant variations from the physiological endometrium of fertile women, Deposiston developes irregularly proliferated patterns in more than 50% of the patients, due to differences of the elimination rate of ethinyloestradiolsulfonate. The degree of proliferation covers a wide range from a slightly proliferated endometrium to changes similar to hyperplasia of the endometrium with cystically enlarged glands. The secretory transformation takes place 2 or 3 days following the progestogen application. In 2 of the cases a secretory pattern could be found several days before the intake of the progestogen. This indicates break-through-ovulations.

Adult↗
PubMed1977

[Determination and assessment of the estrogen proliferation dosage on the human endometrium].

The term, 'proliferation dosage' of an estrogen is defined differently in the gynecologic literature. In this article the authors were concerned critically with the methods of its determination. They came to the conclusion that under standardized conditions sufficiently sure and reproducible results can be received in postmenopausal women. 7 short acting and 3 long acting estrogens, some of which are clinically unknown substances, were examined using the following definition of proliferation dosage: 'Proliferation dosage is the amount of an estrogen which induces the signs of the late proliferation phase after being administered daily in the course of 10 to 14 days to postmenopausal women with atrophic endometrium.' In order to investigate the proliferating properties of 3 depot estrogens a modified test procedure was performed, derived from animal experiments' results and the planned clinical mode of application.

Age Factors↗
PubMed1976

[The neurovegatative reaction-situation in climacteric. Modification of blood pressure regulation by estrogens].

48 women complaining of climacteric disorders were treated with an estrogen preparation for 1 year. Before an intervalls of 2 month during the treatment period studies of the Kupperman index, the vaginal karyopcnotic index and 3 neurovegatative (hemodynamic) tests were carried out: The orthostase-test according to Schellong, the cold-pressor-test according to Hines and Brown, the Pholedrin (Veritol-)test. During estrogen substitution the following alterations could be stated: A significant decrease of systolic and diastolic blood pressure values, a tendency of adjusting the systolic blood pressure values after standing up to the values in rest (Schellong-test I), a shortening of the interval needed to establish stable values of blood pressure and heart frequency, a tendency to reduce the increase of blood pressure in the cold pressor test, and a significant amplification of the increase of blood pressure and blood pressure amplitude in the Pholedrin test. These results are believed to indicate an alteration of vegetative reactivity in the parasympathicomimetic direction. Estrogens seem to exert a favourable influence on the mechanism of blood pressure regulation.

Adult↗
PubMed1975

[Vaginal cytological studies on the new delayed-action estrogen-ethinylestradiol sulfonate].

The colpocytologic efficacy of a new estrogen - ethinylestradiolsulfonate - has been studied in postmenopausal and fertile women. According to the depot character of the compound, ranging between ethinylestradiol and quinestrol, it exhibits a high and prolonged proliferative effect on the atropich vaginal epithelia. The weekly application of 1 mg of the substance in a contraceptive regimen causes a high grade of maturation with considerable individual differences. A single dose of 1 mg ethinylestradiolsulfonate quickly influences conditions of estrogen difficiency in the vaginal epithelia.

Contraceptives, Oral↗