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Biomedical subjects

W C Marsch

Publications and source records attributed to W C Marsch.

At least 109 records · Page 6Linked to original sources
PubMed1985

Generalized racemose livedo with cerebrovascular lesions (Sneddon syndrome): an occlusive arteriolopathy due to proliferation and migration of medial smooth muscle cells.

We describe two cases of livedo racemosa generalisata with cerebrovascular defects (Sneddon syndrome). The histology is characterized by a proliferation and migration of medial smooth muscle cells in ascending arterioles of the upper subcutis and deep dermis. Migrating smooth muscle cells with a high content of intermediate filaments colonize the sub-endothelial intimal space, with subsequent narrowing of the vessel lumen. Since the discoloration of the skin is provoked by a reactive dilatation of venules, the biopsy should be performed in the adjacent normal-looking skin, taking in the upper subcutis.

Adult↗
PubMed1984

Epidermoid metaplasia in apocrine cystadenoma of the penis. An ultrastructural analysis.

Two cystadenomas occurring near the frenulum of the penis revealed a predominantly secretory pseudostratified columnar epithelium with PAS-reactive dome-shaped cytoplasmic protrusions at the luminal cellular parts. The content of secretory vacuoles was discharged into the cyst lumen by an exocytotic (eccrine) and ballooning type of extrusion. There were no indications of a real apocrine extrusion mechanism. No histogenetic derivation of these penile cystadenomas from apocrine sweat glands could be proved. An antennalike filamentous fuzzy coat on the luminal cytoplasmic membrane was most remarkable. Regionally, an epidermoid differentiation had developed. Morphologically, this process had begun just above the basal cell layer which had remained unchanged and led to the establishment of a stratified epithelium. Hyalin lamellarlike flattened cells at the luminal part displayed necrobiotic features and resembled periderm cells. There was no keratin pattern. Luminal cells of epidermoid differentiation still revealed a filamentous fuzzy coat which indicated that the undifferentiated cuboidal basal cells basically had a prospective secretory meaning and probably represented the target cells in the process of metaplasia.

Adult↗
PubMed1984

[Ultrastructure of eruptive capillary hemangioma (granuloma pyogenicum sive teleangiectaticum)].

Twelve lesions of so-called granuloma pyogenicum of the skin were examined by electron microscopy. The process is initially characterized by a solid proliferation of endothelial cells. The lumen is formed by a distention of the intercellular space and by invaginations of the cytoplasmic membrane. Even the walls of greatly ectatic vessels are only lined by endothelial cells, which is an indication for their capillary nature. Weibel-Palade bodies are rare. The basal lamina is born in the process of lumen formation and flattening of the endothelial cells. Cytoplasmic blebs on endothelial cell surfaces represent aqueous compartments. Their appearance probably results from a lack of energy supply due to an insufficient microcirculation. Exulceration of the epifocal epidermis is definitely a secondary event and leads to direct contact of the capillary vascular tissue with living and nonliving agents in the environment. This induces a strong acute inflammatory response, which results in fibrin exudation and emigration of neutrophilic granulocytes. The lesion is a benign vascular tumour. Therefore the term "eruptive capillary hemangioma" is justified.

Capillaries↗
PubMed1983

Cutaneous squamous cell carcinoma with unicellular mucoprotein accumulation.

The difficulty of differentiating an epithelial skin tumour with partial adenoid histological features from a metastasis of an internal adenocarcinoma is exemplified by a case report of an 83-year-old woman. Histological, histochemical and ultrastructural results led us to suppose that two different carcinomas with metastases were present: an adenocarcinoma of the colon and a 'unicellular muciparous squamous cell carcinoma of the skin'. The nosological proximity of the primary skin tumour to mucoepidermoid tumours and to sweat gland carcinoma of the ductular epithelium will be considered in more detail.

Adenocarcinoma, Papillary↗
PubMed1982

[Ultrastructure of "acrobullous dermatosis" induced by PUVA-therapy in psoriasis].

Report about a 44-year-old psoriatic female who developed recurrent bullous eruptions on her extremities during oral photochemotherapy. Ultrastructural analysis revealed an epidermolytic blister formation due to cytolytic alteration of infranuclear parts of basal cells. Pathogenetically, an initial subclinical phototoxic alteration of the epidermodermal coherence is assumed which may lead to a visible bulla by an additional mechanical trauma. There was no evidence for a subclinical bullous pemphigoid.

Adult↗
PubMed1982

[Develop of localized pemphigoid following radiation treatment (author's transl)].

A case of localized bullous pemphigoid in a 79-year-old woman is reported. The symptoms developed 5 months following radiation treatment of breast cancer. Direct immunofluorescence investigations showed IgG and C3 deposition in the basement membrane zone (BMZ) of lesional skin. Serum BMZ antibodies (IgG, IgM) and C3 deposition were demonstrated. Light microscopic investigation revealed subepidermal blister formation. A cellular infiltrate consisted predominantly of lymphocytes and eosinophils in the upper dermis. Junctional blister formation, located within the lamina lucida of the basement membrane, was confirmed by electron microscopy. Differential diagnoses and various possible etiologies are discussed.

Aged↗
PubMed1982

[Occlusive thrombotic lymphangiofibrosis of the penis].

The disease is characterized by a painless tender and mainly worm-like lesion which partly or totally encircles the distal penis, proximal of the sulcus coronarius. Usually, there are no local or regional inflammatory signs of the glans, preputium, or the inguinal lymph nodes. The anatomic target is a lymphatic collecting vessel. The pathologic process is morphologically based on three major features: lymphostasis, coagulation thrombus formation, and vessel wall thickening. We therefore propose the term lymphangiofibrosis thrombotica occlusiva. Men 20-40 years of age are most commonly affected. A therapeutic measure is not necessary, unless there is no spontaneous regression which one can except in 90% of the patients within 2 months. Mechanical and unknown microbiologic insults are discussed as etiological factors. Furthermore, the topographical distribution of blood and lymphatic vessels of the distal penis region is delineated. Six patients are presented with the clinical data.

Adult↗
PubMed1981

[A case of ichthyosis hystrix gravior unilateralis - clinical and morphological data (author's transl)].

A male newborn demonstrated an extensive unilateral hystrix-like hyperkeratosis. The child died 17 days post partum with the clinical sign of congestive right heart failure. The autopsy revealed various anomalies of the blood and lymph vessel system. Lightmicroscopically the affected skin demonstrated a saw-edge configuration of the orthohyperkeratotic epidermis due to a prominent papillomatosis with a narrow basis. An acanthokeratolytic (epidermolytic) hyperkeratosis was absent. Round granules (phi 0,25-1,3 micrometer) bounded by a double membrane and with tubulovesicular structures within an electron dense matrix were conspicious in karatinocytes of the stratum granulosum. The case is termed "Ichthyosis hystrix gavior unilateralis".

Diagnosis, Differential↗
PubMed1981

[Granuloma anulare--an indication for photochemotherapy? (author's transl)].

Typical granuloma anulare lesions of 2 years duration on the elbows of a 50-year-old woman cleared completely after intense sunlight exposure. A recurrence resolved under local PUVA-treatment (total dose 10.2 Joule/cm2). An extended study is needed to evaluate the usefulness of PUVA-therapy in granuloma anulare.

Elbow↗
PubMed1981

Sclerosing lymphangitis of the penis: a lymphangiofibrosis thrombotica occlusiva.

Three patients with so-called non-venereal sclerosing lymphangitis of the penis are presented. Light and electron microscopy of one case revealed a lymphatic collecting vessel with a fibrin thrombus in the process of recanalization and vessel wall fibrosis due to hyperplasia of smooth muscle cells and fibroblasts. The term 'lymphangiofibrosis thrombotica occlusiva' is proposed. Lymph stasis is suggested as a provoking factor for the dilatation and clinically striking firm thickening of the affected collecting vessel. No microorganisms were recognized. Within the fibrin thrombus, sprouts of endothelial cells showed intracellular vacuoles, probably indicating the first identifiable step in lymph capillary lumen formation. Signs of collagen remodelling were encountered in the thickened vessel wall.

Adult↗
PubMed1979

[Adenoma of the nipples].

The adenoma of the nipple (syn.: erosive adenomatosis, papillary adenoma, florid papillomatosis) is a benign tumour of the major nipple ducts and presents chiefly as an eroded oozing and crusted lesion with serous or sanguineous discharge of the nipple or as an indurated nodule. The lesion can be mistaken clinically for Paget's disease of the nipple. The correct diagnosis, however, can easily be established by an incisional biopsy. Pathohistologically, the tumour displays adenomatous and papillomatous proliferation of the milk sinus epithelium. An outer myoepithelial and inner columnar epithelium layer can mostly be distinguished. Atypical cellular features are lacking. Keratin cysts near the mostly eroded epidermal surface are are additional characteristic signs. The resection of the nipple is the therapy of choice. The adenoma of the nipple is no precancerous condition. A typical case of adenoma of the nipple from a 54 year old woman is presented.

Adenoma↗
PubMed1979

[Panniculitis nodularis febrilis non suppurative in metastasizing soft-tissue sarcoma].

Report of a 28-year-old female patient with a metastasizing soft tissue sarcoma confined to the oral mucosa and subcutis. The basic disease attracted clinical attention as a nodular febrile nonsuppurative panniculitis (Pfeifer-Weber-Christian disease). Perivascular tumor cells in the subcutis obviously induced localized fat necroses. Ultrastructurally, the pathological cells showed no indicative cytological characteristics other than a close association with reticulin fibers. Apparently, a metastasizing tumor disease can be concealed under the clinical picture of a nodular febrile non suppurative panniculitis--as a paraneoplastic syndrome.

Adult↗
PubMed1978

Ultrastructural detection of Haemophilus ducreyi in biopsies of chancroid.

During an endemic appearance of chancroids (26 cases) in Berlin (West) coccobacilli were disclosed in biopsies by electron microscopy. The bacteria were aggregated predominantly in groups in the extracellular space. Their cell wall is approximately 120 A thick and trilaminar as in Gram-negative bacteria. Concerning the cell wall structure and the cytoplasmic composition, the detected coccobacilli are identical to culturally grown Haemophilus ducreyi obtained from chancroids.

Chancroid↗
PubMed1978

The ultrastructure of mycobacterium marinum granuloma in man.

3 biopsies of 3-5 week-old nodular lesions in 2 patients with so-called swimming-pool (aquarium-) granuloma have been examined by electron microscopy. The cytohistological spectrum simultaneously comprises acute exudative as well as chronic proliferative phenomena. Epithelioid cells and collagen producing fibroblasts are already conspicious in 3 week-old granuloma. According to the cytological composition the Mycobacterium marinum granuloma represents a high-turnover granuloma with immunogenic origin. It is comparable to mycobacterial diseases in the presence of well developed cell mediated immunity (Lupus vulgaris, tuberculoid leprosy). Degrading mycobacteria have been rarely detected in phagocytes and are compared with viable bacilli in macrophages of experimentally infected mice. Curved and annular parallel membranes ("worm-like structures") in the cytoplasm of transformed macrophages and in fibroblasts presumably originate from the membranes of endoplasmic reticulum. Cord-like structures with transverse bands (periodicity 170-180 A) in the lumen of RER of some fibroblasts are interpreted as intracellularly aggregated collagen precursors.

Adolescent↗
PubMed1978

Actinic elastosis in black skin. A light- and electronmicroscopic study.

In 9 otherwise dermatologically normal South African Balck volunteers (1--72 years old), sunlight-exposed and non-exposed skin has been examined by light- and electronmicroscopy with special references to age-dependent and actinic alteration of dermal structures. Two 72 year old Blacks exhibited typical dermal elastosis: in 1 case to a marked extent and already detectable by lightmicroscopy, in the other case only to a mild degree. In contrast, only age-related elastic fibers were revealed in the lower dermis of sunlight-exposed skin and in all dermal layers of unexposed skin. These observations are contradictory to the general view that actinic elastosis does not occur in Blacks. The elastotic material is obviously a de-novo synthesized and secreted pathological product of chronically UV-altered fibroblasts.

Adolescent↗