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Biomedical subjects

W C Marsch

Publications and source records attributed to W C Marsch.

At least 91 records · Page 5Linked to original sources
PubMed1990

Papular eruption in helminth infestation--a hypersensitivity phenomenon? Report of four cases.

This communication reports on generalized papular eruption in Man, coinciding with infestation due to dwarf tapeworm (Hymenolepis nana), pinworm (Enterobius vermicularis) and whipworm (Trichuris trichiura). The assumed allergic-hyperergic reaction was evident from itching, blood and tissue eosinophilia, increased serum IgE and clearing up after focus of infestation therapy. Pinworm and whipworm therapy was initially accompanied by Jarisch-Herxheimer phenomenon.

Adolescent↗
PubMed1990

[Lichen ruber exanthematicus et pigmentosus in mercury poisoning. A contribution to individual pathology in occupational medicine].

We report on a 21-year-old man professionally exposed to mercury, who developed lichen planus. This case must be regarded as a dispositional reaction and is in Germany entitled to indemnification in terms of a "quasi-occupational disease". The clinical signs and the probably non-allergic pathomechanism are comparable with those of lichen planus induced by gold. In diseases due to occupational intoxication, we face an individual disposition regarding the degree of clinical symptoms, which has to underly any expert opinion on indemnity.

Adult↗
PubMed1990

[The fractals theory and its significance for dermatology].

Classic mathematical methods are frequently not suitable for the investigation of complex "natural" shapes, that cannot be approximated by geometric structures. A theory developed by Mandelbrot has made it possible to analyse such "fractals". Many biological and medical shapes could be identified as fractal. These results suggest fractal structures for some dermatological lesions. This is particularly true for skin lesions related to the vascular system (e.g., livedo racemosa, spider naevus). Furthermore, computer simulation of pathogenetic mechanisms can demonstrate that the lesions of a skin disease are fractal in nature. This method can be applied to skin tumours with horizontal cell growth (e.g., carcinoma and melanoma in situ) and to the architecture of spider naevus.

Computer Simulation↗
PubMed1990

[Woronoff rings in a mathematical model].

The width of a Woronoff ring is thought to be constant and independent of the diameter of the lesion. Clinical observations have allowed us to demonstrate that this is true only for lesions of a certain minimum size or greater. It is suggested that the paleness within the ring is caused by diffusion of a mediator from the psoriatic plaque into its environment. A mathematical model is formulated, and it is shown that clinical observations are consistent with the pathogenetic hypothesis. In addition, the mathematical model is used to derive some properties of the hypothetical mediator.

Diffusion↗
PubMed1989

[Pemphigus herpetiformis--the value of simple diagnostic measures].

Herpetiform pemphigus is a rare variety of pemphigus vulgaris. Although the final diagnosis requires thorough clinical, histological and immunological investigations, there are simple examinations which may be carried out at once (such as assessment of blister stability, negative Nikolski's sign, predominance of eosinophils, spongiotic and non-acantholytic epidermal cells in the Tzanck smear). These ad hoc findings may help the practising dermatologist to tell herpetiform pemphigus from other blistering diseases. We discuss and evaluate the various diagnostic procedures regarding herpetiform pemphigus.

Aged↗
PubMed1989

[The Kyrle disease entity and its therapeutic modification by acitretin (etretin)].

We report on a 50-year-old woman having suffered from atypically located Kyrle's disease for 2 years. Especially the palmoplantar areas were affected by keratotic erythematous papules showing the typical histologic picture of Kyrle's disease. Treatment with acitretin (initial dose 30 mg/day) resulted in almost complete remission after 6 months. A concomitant lichen nitidus remained unchanged.

Acitretin↗
PubMed1987

[Symptomatic livedo racemosa in cholesterol embolism with occlusion of the arterioles in the area of the corium-subcutis].

We report on a 70-year-old woman suffering from diabetes mellitus dependent on insulin and associated with malignant hypertension. Following heart catheter examination for the dilatation of the renal arteries, she developed acute, painful, persistent livedo racemosa of the buttocks and the lower extremities. Histological investigation revealed embolism of cholesterol crystals in arterioles of the corium-subcutis region. On the basis of the cases described in the literature so far, we discuss the clinical spectrum of cutaneous cholesterol embolism.

Aged↗
PubMed1987

Antimutagenic potency of the cytotoxic and anti-psoriatic compound anthralin (cignolin).

The anti-psoriatic compound anthralin (cignolin) was determined to exhibit a strong cytostatic activity on HeLa-Köln cells; an ED50 concentration of 1.2 microM are cytotoxic for the cells. These growth-inhibition data were confirmed by thymidine-uptake experiments. The drug anthralin was determined to be neither direct a mutagen nor a premutagen in the Ames test using Salmonella typhimurium strain TA 100 (anthralin-concentration = 5 microM). Moreover, this compound was a strong inhibitor of benzo(a)pyrene monooxygenase, an enzyme which causes the metabolic conversion of premutagens to mutagens. These data demonstrate anthralin to be an anti-psoriatic compound devoid of mutagenic property in vitro with regard to base-pair substitutions and provided at least with some antimutagenic potential.

Anthralin↗
PubMed1987

[Stewart-Treves syndrome: hemangiosarcoma in chronic lymphedema. Ultrastructural analysis of various clinical developmental stages].

Ultrastructural studies of angiosarcoma in chronic lymphedema (Stewart-Treves syndrome) at various stages of development show that endothelial cell proliferation originates not in the lymphatic but in the blood capillary vessels. The results indicate that the term "lymphangiosarcoma" is no longer suitable to describe the histopathologic characteristics of Stewart-Treves syndrome.

Aged↗
PubMed1987

[Urticaria pigmentosa--an obligate systemic disease? Results of nuclear medicine studies and etiopathogenetic significance].

The objective of the present investigation was to establish the frequency of systemic spreading of urticaria pigmentosa by means of bone and bone marrow scintigraphy as a noninvasive imaging technique with a low radiation exposure. Bone scintigraphy: Seven of nine patients investigated showed diffuse and focal nuclide accumulation. After exclusion of other causes by reference to the case history and the clinical and chemical laboratory findings, these nuclide accumulations were regarded as mastocytosis-specific in accordance with the atypical localization. Bone-marrow scintigraphy: All the patient investigated showed a peripheral expansion of the bone marrow. This must be interpreted as an expansion of the macrophages of the bone marrow on the basis of the method used. Since the mast cell is regarded as a more highly differentiated form of the same cell-type as macrophages/monocytes, on the basis of the scintigraphic results presented, urticaria pigmentosa can be regarded pathogenetically as a hyperplasia of the macrophages of the bone marrow organ, with increased differentiation in mast cells. The extent of this differentiation and its pathological quality then determine the clinical signs and symptoms (cutaneous, systemic, or malignant mastocytosis). Urticaria pigmentosa thus has the character of a systemic disease.

Adult↗
PubMed1986

[Multiple generalized glomus tumors. Morphologic and biochemical findings].

A 54 year-old woman developed approximately 150 generalized glomus tumors since she had been 23 years old. Painful tumors showed more glomus cells than those being not painful. Furthermore, the patient suffered from persisting congenital capillary hemangioma (strawberry mark). Histological examination revealed that glomus cells were located in the vessel walls. The large amount of Dopa found in the glomus tumor tissue supports the assumption that it may be innervated by adrenergic efferent nerves.

Cyclic AMP↗
PubMed1986

Bleomycin enhances the tyrosinase activity of human malignant melanoma cells in culture.

By application of bleomycin fine pigmentations on basal cell layers will appear in irritated parts of the skin. Therefore we investigated the effect of bleomycin on the tyrosinase activity. Bleomycin was determined to exhibit a strong cytostatic activity on human melanoma cells in culture (ED50 concentration = 0.21 microgram/ml) whereas the viability of the cells was not affected. Incubation of pigmented human melanoma cells in the presence of bleomycin containing culture medium (1-100 ng/ml) at 37 degrees C for different periods of time resulted in a marked increase of tyrosinase activity. The level of enzyme activity reached 140% if the controls were set to 100%. Direct addition of bleomycin to the crude cell extract produced no detectable stimulatory effect. There were no significant stimulation if the cells were grown with bleomycin in serum-free culture medium. The serum content influences the activity of tyrosinase in a marked degree. The serum concentration for half-maximal stimulation of tyrosinase was calculated to be 14.2%. Furthermore the inflammatory mediator histamine was found to stimulate tyrosinase in melanoma cells. There were no additional stimulatory effect if cells were incubated in the presence of both histamine and bleomycin. These results suggest that bleomycin is able to enhance tyrosinase activity in intact cell systems. Further a possible role of serum and/or inflammatory factors in the stimulatory process must be considered.

Basidiomycota↗
PubMed1986

HLA-B 16 in Hailey-Hailey's disease.

Hailey-Hailey's disease is an autosomal hereditary disease of the skin for which only few data exist in regard to genetic markers concerning the HLA system. We report on HLA-A, B and C typing results finding an increased frequency of 55.5% HLA-B 16 positive patients compared to 8.2% in healthy controls.

Adolescent↗
PubMed1986

'Mondor's phlebitis'--a lymphovascular process. Light and electron microscopic indications.

Histological details of 2 cases of 'Mondor's phlebitis' suggest that we are dealing with a process affecting lymphatic vessels. Fibrin thrombus formation with mycotic organization and capillary recanalization as well as fibromuscular hyperplasia of the vessel wall with infiltration of the surrounding fatty tissue determine the pathogenesis of the disease. 'Lymphangiofibrosis thrombotica occlusiva' is a more appropriate term.

Adult↗
PubMed1986

[Toxic shock syndrome].

A 23-year-old woman developed mitigated toxic shock syndrome while using intravaginal tampons during menstruation. The Staphylococcus aureus strain isolated from the vaginal epithelium produced the responsible exotoxin (TSST-1).

Adult↗
PubMed1985

[Borreliosis--still a diagnostic labyrinth].

Acrodermatitis chronica atrophicans and meningo-polyneuritis Garin-Bujadoux-Bannwarth following initial erythema migrans represent infectious diseases and may lead to diagnostic misinterpretation. Three case reports illustrate the spirochetal nature of these entities usually transmitted by ticks (Ixodes ricinus).

Acrodermatitis↗
PubMed1985

[Livedo racemosa generalisata. Clinical aspects and histopathology of obliterating arteriolopathy with CNS involvement].

The histopathology of Sneddon's syndrome (livedo racemosa generalisata and cerebrovascular defects) is characterized by a thickened intima with subsequent narrowing of the lumen of ascending arterioles in the upper subcutaneous tissue and deep dermis. Ultrastructurally, migrating medial smooth muscle cells with plenty of intermediate filaments colonize the subendothelial intimal space ("intima proliferation").

Adult↗