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Biomedical subjects

W C Lambert

Publications and source records attributed to W C Lambert.

At least 109 records · Page 6Linked to original sources
PubMed1985

Colonization of nonmelanocytic cutaneous lesions by dendritic melanocytic cells: a simulant of acral-lentiginous (palmar-plantar-subungual-mucosal) melanoma.

Four cases of colonization of nonmelanocytic lesions by dendritic melanocytic cells are reported, one in a verruca vulgaris of the lip, one in a squamous cell carcinoma in situ of mucous membrane overlying a tonsil, one in a lesion of lichen simplex chronicus with a nevocellular nevus of the external ear, and one in a dermatofibrosarcoma protuberans (Bednar tumor). This is an important biological process of melanocytes that must not be confused with the acral-lentiginous (palmar-plantar-subungual-mucosal (P-S-M) melanoma. It is probably much more common than the paucity of published reports would indicate.

Adult↗
PubMed1985

Co-recessive inheritance: a model for DNA repair, genetic disease and carcinogenesis.

A genetic model for some cases of excision-deficient xeroderma pigmentosum (XP) is proposed in which the trait (i.e., XP) is expressed if and only if the individual is homozygous or hemizygous for defective alleles at more than one of a specific set of loci. The model might also apply in some cases of certain other diseases associated with defective DNA repair. The model accounts for several paradoxical aspects of XP, including the large number of complementation groups despite the biochemically limited DNA-repair defect, the co-existence of XP and Cockayne's syndrome in two different complementation groups of XP, siblings with markedly different degrees of severity of XP in one family and transmission of the disease in an X-linked manner in another, the existence of some individuals who appear to have the DNA-repair defect but not clinical XP, and the seeming paradox of a disease associated with a marked defect in a DNA-repair mechanism but not associated with an obvious increase in incidence of internal cancer. The model predicts that a large proportion of the general population is a carrier of one or more of these defective genes for DNA-repair mechanisms. Such genes may be important in the etiology of much of human cancer.

Chromosome Mapping↗
PubMed1985

Neonatal lupus erythematosus, multiple thromboses, and monoarthritis in a family with Ro antibody.

We describe a family afflicted with striking clinical and serologic autoimmune features. The mother and maternal uncle of a patient with neonatal lupus had rheumatic disease manifestations. All three had Ro antibodies (SS-A) in their sera, as well as La antibody (SS-B). The 17-year-old mother developed postpartum inflammatory monoarthritis of the right knee and had a positive lupus band test. The uncle at the age of 26 developed a fulminant disease most consistent with systemic lupus erythematosus (SLE); initial manifestations were myocardial infarction, deep vein thrombosis, and the nephrotic syndrome. Although it is known that mothers of neonatal lupus infants can develop SLE postpartum, the development of severe disease in the maternal uncle suggests the relevance of identifying seropositive relatives of individuals with neonatal lupus.

Adolescent↗
PubMed1985

Power analysis in dermatohistopathology.

Magnification of histologic and ultrastructural photoimages is frequently misrepresented in published reports. "Power," P, the usual mode of representation of magnification, is defined as the ratio of the distance between two points on the photoimage to that between the same two points on the original specimen, but is idiomatically denoted as xP rather than the mathematically correct xP2 in common usage. In this publication, the definitions of "power" and "area magnification," the relationship between "original magnification," "resolving power," and "empty magnification," sources of error that may be introduced during processing of papers for publication, and the relationship between magnification and perception are delineated. Practical suggestions, arising from this discussion, for expression of magnifications when publishing photoimages and for dealing with projected photoimages are provided.

Humans↗
PubMed1985

Cutaneous nasociliary neuralgia.

Nasociliary neuralgia has not to our knowledge been linked with inflammatory cutaneous lesions. We observed the phenomenon and postulate that it may be frequent but overlooked.

Acne Vulgaris↗
PubMed1985

Premycotic eruptions.

Virtually any longstanding, recalcitrant inflammatory dermatosis may evolve into a cutaneous T-cell lymphoma. Although several entities within the parapsoriasis group can undergo malignant degeneration, most cases of cutaneous T-cell lymphoma are not preceded by parapsoriasis; a preceding inflammatory dermatosis that is not a parapsoriasis may be much more common. Among the parapsoriasis, lymphomatoid papulosis and large-plaque parapsoriasis and its variant, retiform parapsoriasis, have a variable tendency to undergo malignant degeneration. For any dermatosis deemed to have a significant premalignant potential, a plan of aggressive management with relatively non-aggressive modalities (for example, topical steroids, UVB light, and psoralen plus UVA light) should be considered.

Antibodies, Monoclonal↗
PubMed1984

Keratosis punctata and atopy. Report of 31 cases with a prospective study of prevalence.

We report 31 cases of keratosis punctata palmaris et plantaris in blacks. Eleven of these were found in a prospective study of 573 consecutive black private dermatologic outpatients, a prevalence of 1.9%, and 20 cases were randomly encountered over a three-year period in the same office. Five of the 30 patients able to give a history were symptomatic, and they and ten others came to the office because of this disease, where as 15 came for other reasons, two of whom were unaware of the disease. Four of the 31 patients also had foot lesions. Four patients were aware of relatives with palmar keratoses. The mean duration of disease was 4.3 years, the median was three years, and the range was zero to 38 years. The mean age at onset was 30.3 years, the median was 29 years, and the range was 12 to 70 years, with one case beginning in infancy. Each patient in the prospective study was examined for personal atopy or for a family history of atopy. Nine (82%) of the 11 patients with keratosis punctata had atopy and/or a family history of atopy. Statistical analysis confirmed the association between keratosis punctata and atopy in the prospective study.

Adolescent↗
PubMed1984

Intraoral melanoacanthoma.

A 39-year-old black woman noted a pigmented lesion on her right buccal mucosa of which she had been previously unaware. Physical examination revealed a 2.0 X 1.8-cm uniformly pigmented, macular to slightly plaque-like, symmetrically folded, indented lesion. Histologic examination revealed a hyperplastic mucous membrane containing numerous dendritic melanocytes at all levels. No pleomorphism or cytological atypia was recognized and no fibrosis was present in the corium. The case was diagnosed as "melanoacanthoma."

Adult↗
PubMed1984

Metastasizing basal cell carcinoma developing in a gunshot wound in a black man.

Both basal cell carcinomas that arise in blacks and those that metastasize are rare, and development of this tumor is an uncommon, late complication of trauma. We report a case of a 70-year-old black man with a basal cell carcinoma arising in a gunshot wound in a shoulder and metastasizing to axillary lymph nodes. Histologically, the tumor was of the metatypical type.

Aged↗
PubMed1984

The giant apocrine hidrocystoma.

We report a patient with a large apocrine hidrocystoma. These tumors are almost always under 10 mm in diameter. In this 40-year-old man the tumor measured 20 mm. Apocrine hidrocystoma must be considered when evaluating a patient with a large cystic lesion of the face. Surgical management is similar to that of other benign cystic lesions of this region.

Adult↗
PubMed1984

Criteria for diagnosis in dermatology and dermatopathology: a critical evaluation.

The logical processes of application of criteria to make diagnoses in dermatology and dermatopathology are examined. The limitations of use of a single criterion are delineated, and the advantages and limitations of multiple criteria are defined. It is important that all diagnostic criteria be applied with careful attention to the frequency of the designated entity in the study population and the sensitivities and specificities of the criteria used. The exclusive use of single, "favorite" criteria should be avoided, and multiple criteria should be applied, whenever possible.

Bayes Theorem↗
PubMed1984

Acute neutrophilic dermatosis with diffuse histiocytic lymphoma.

We report an elderly man with acute neutrophilic dermatosis (AND) associated with a diffuse histiocytic lymphoma. This cutaneous marker of internal malignancy is usually associated with myeloproliferative disorders. To our knowledge this case is the first linkage of AND with this type of lymphoma.

Humans↗
PubMed1984

Linear localized coumarin necrosis.

We report a 55-year-old man with coumarin necrosis. This drug eruption is sometimes a devastating gangrenous process in sites with abundant underlying adipose tissue. In our patient, however, it assumed an evanescent limited linear distribution on the skin, prompting this report.

Drug Eruptions↗
PubMed1984

The retinoids in acne.

Vitamin A is essential for growth and development, reproduction and vision in humans. Chemical modification of vitamin A has yielded compounds showing therapeutic promise in skin and neoplastic diseases. The medicinal use of retinoids (vitamin A and its derivatives) is limited by the toxicity associated with this group of compounds. One retinoid, 13-cis-retinoic acid, has proved to be quite effective in the treatment of severe recalcitrant cystic acne under conditions in which toxicity is manageable.

Acne Vulgaris↗
PubMed1984

Trichoepithelioma in a systematized epidermal nevus with acantholytic dyskeratosis. Its occurrence in a black man.

A 2-cm nodular neoplasm in the left parietal region developed in a 52-year-old black man with a 20-year history of a systematized epidermal nevus of the scalp. On biopsy, the epidermal nevus showed both "church spire" papillary changes and multiple foci of acantholytic dyskeratosis. The neoplasm showed quite distinct histopathologic patterns of trichoepithelioma.

Acantholysis↗
PubMed1984

Nodal and subcutaneous cellular blue nevi. A pseudometastasizing pseudomelanoma.

A 20-year-old white woman had extensive surgery for "metastatic melanoma" of the dorsum of the right foot and surgical removal of two regional inguinal lymph nodes. Review of the histopathological sections ten years later revealed all three lesions to be cellular blue nevi. Cellular blue nevi may resemble melanoma histologically and, relative to their incidence, are quite frequently found in lymph nodes. Thus they may present a uniquely challenging differential diagnosis with metastatic melanoma.

Adult↗