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Biomedical subjects

W B Martin

Publications and source records attributed to W B Martin.

At least 37 records · Page 2Linked to original sources

Experimental immunisation of lambs against pneumonic pasteurellosis.

Methods of immunising lambs against pneumonic pasteurellosis, caused by several serotypes of Pasteurella haemolytica, were assessed in specific pathogen free lambs. Lambs were vaccinated intramuscularly with sodium salicylate extract (SSE) of P haemolytica, either alone or in combination with heat-killed organisms (HKO). SSE of P haemolytica type A1 protected vaccinated lambs against pneumonia resulting from challenge with the homologous serotype. SSE of type A2 also provided some protection but this was improved by vaccination with a combination of SSE and HKO.

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Staphylococcal dermatitis of sheep.

A condition frequently termed "facial" or "periorbital eczema" has been observed in sheep. Studies carried out indicated no viral involvement but a haemolytic Staphylococcus aureus was isolated which produced severe necrotic skin lesions on inoculation into sheep. A more appropriate term for the condition would appear to be staphylococcal dermatitis.

Animals↗

Latent infection of cattle with bovid herpesvirus 2.

In a series of experiments, 10 calves were infected by different routes with bovine mammillitis strain of bovid herpesvirus 2 (BHV2). Nine of the calves developed lesions and BHV2 was isolated from 8 calves. At intervals, after clinical recovery, the calves were given a course of corticosteroid by intravenous injection. Subsequently 7 calves developed lesions and from 3 calves BHV2 was reisolated. The shortest interval between initial infection and reisolation of virus was 10 weeks. In one calf virus was recovered on 3 occasions, at intervals of 20, 44 and 74 weeks post-infection. It is probable that BHV2 can occur as a latent infection in calves and that BHV2 should be included among the herpesviruses known to remain latent.

Animals↗

Reduced mitogenic responses in cultures of lymphocytes from newly calved cows.

The proliferative responses to stimulation with phytohaemagglutinin (PHA) in cultures of lymphocytes from newly calved and non-pregnant cattle were compared. Lymphocyte cultures from newly calved cows were seen to respond less to PHA than cultures from the non-pregnant cows. It is suggested that this depression in responsiveness of lymphocytes in the immediate post-parturient period may be involved in the etiology of disease in cattle during the immediate post-parturient period.

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