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Biomedical subjects

W Arossa

Publications and source records attributed to W Arossa.

At least 37 records · Page 2Linked to original sources

Site of airway obstruction after rapid saline infusion in healthy subjects.

Static and dynamic lung volumes, flow-volume curve in air and after He-O2 were carried out in 5 normal subjects baseline, immediately after rapid infusion of 2 litres of normal saline, and then 15, 30 and 60 min after. At the end of the infusion, a marked reduction of delta MEF50, FVC, FEV1, MEF50, MEF25 and an increase of Viso V and CV/VC were observed in all the subjects. The poor response to He-O2 suggests a predominant increase of small airway resistance after rapid infusion. In the recovery phase, He-O2 tests promptly returned to control values, while an increased CV/VC was detectable until 30 min after the infusion.

Adult↗

[Radiologic determination of total lung capacity].

The authors studied in 50 healthy subjects the cilindroid and the planimetric method for the radiological measurement of TLC. Both methods proved to be accurate, but the first showed a better relation with the pletismographic measurements; in both methods the individual variability was very limited (5 divided by 6%). In a screening protocol comprising double-projection chest X-ray, the radiological measurement of TLC seems to be very useful to evaluate with simplicity and realiability its values and its variations in time.

Adult↗

Radiographic and functional changes following exposure to different types of asbestos.

Lung function parameters were examined in 200 asbestos workers. Those exposed to chrysotile alone had less severe impairment than those exposed to both chrysotile and crocidolite. Functional changes did not vary significantly with duration of exposure; however radiographic abnormalities were related to length of exposure. Our results show that, for a population with moderate exposure to asbestos, lung function tests can discriminate smokers and nonsmokers and exposure to different kinds of asbestos, whereas discrepancies among groups with different lengths of exposure are better seen with radiographic methods.

Adult↗

The effects of air pollution on the respiratory health of children: a cross-sectional study.

To investigate the effects of air pollution on the respiratory health of children, a subject of some controversy, a comparative study was undertaken of 2,385 school children who lived in central urban, peripheral urban, and suburban areas. Daily monitoring of sulphur dioxide and total suspended particle concentrations in all areas showed that pollutant concentrations in central and peripheral urban areas were above commonly accepted safety levels for respiratory health, while concentrations in the suburban area were within acceptable limits. A questionnaire administered to each mother assessed environmental exposure to pollutants in the household, the occurrence of respiratory symptoms as well as lung diseases as diagnosed by a physician, and general information. Children were interviewed about smoking habits and any acute respiratory symptoms. Children also performed standard lung function tests. Results showed that children from both urban areas had lessened pulmonary function and a higher prevalence of bronchial secretion with common colds than did those from the suburban area. These differences persisted after corrections for exposure to indoor pollutants, active or passive smoking, socioeconomic status, and sex. Parental cigarette smoking was related to a fall in forced expiratory volume in 1 second and an increased incidence of acute respiratory illnesses and chronic cough in children. Although boys had higher lung volumes and lower air flow, regression analysis showed no significant influence of the interactions "sex-geographic area" and "sex-smoking" on lung function. It was concluded that air pollution has a significant effect on the respiratory health of children.

Air Pollutants↗

A computer-assisted technique for long-term gastric pH monitoring.

A computer-assisted technique for prolonged gastric pH monitoring has been developed using a personal computer. Segments of signal from several studies performed in controls and on patients with duodenal ulcers were chosen for comparison between manual and digital pH readings; no significant difference was detected. In clinical practice this system might provide an additional tool in the diagnostic and therapeutic treatment of peptic ulcer disease.

Computers↗

Changes in lung function of children after an air pollution decrease.

Forced vital capacity (FVC), forced expiratory volume in 1 sec (FEV1.0), forced expiratory flow between 25 and 75% of FVC (FEF25-75), and maximal expiratory flow at 50% of FVC (MEF50) were measured in 1,880 school children who lived in urban areas before and after a decrease of air pollution. A group of 162 children from a suburban area served as controls. In the first survey, FEV1.0, FEF25-75, and MEF50 of children from urban areas were significantly lower, while in the second survey they were not significantly different from those of controls. The slopes over time of FEV1.0, FEF25-75, and MEF50, adjusted for sex and anthropometric variables, were closely related to the decrease of pollutants concentration. Our results suggest that a decrease of air pollution may produce an improvement of lung function.

Adolescent↗

Involuntary exposure to tobacco smoke in adolescents: urinary cotinine and environmental factors.

The relationship between environmental tobacco smoke exposure and urinary cotinine was studied in 434 14-y-old schoolchildren. To estimate the independent contribution of physiological and environmental variables to cotinine concentrations, we conducted a multiple regression analysis of log-transformed cotinine (R(2) = .21, p < .0001). Environmental tobacco smoke exposure was associated with sharing a household with members who smoked. The most profound associations were linked to (a) the smoking habits of the mother (beta = 5.135, p = .0397); (b) the combined smoking habits of the mother and other family members (beta = 8.201, p = .0020); and (c) the total number cigarettes smoked each day by family members in the household (beta = 0.217, p = .0008). Passive smoke exposure of adolescents is a preventable risk that could be reduced by improving ventilation and by increasing the living space available to each family member. Parents should avoid smoking at home in the presence of their children.

Adolescent↗

Chronic bronchitis in the iron and steel industry: prevalence study.

The paper reports the results of a prevalence study on functional impairment and chronic bronchitis in 733 foundry workers and in a control group of 1041 workers not exposed to the specific risks of the iron and steel industry. This study is the first part of a longitudinal study lasting 5 years within the framework of the Fourth Research Programme of the European Coal and Steel Community. Data on microclimate and particulate pollution for the various departments showed uniformly cold and damp conditions. Concentrations of pollutants were generally below the current T.L.V.'s. The subjects were subdivided into groups according to age, smoking and length of exposure. All the subjects were administered the "E.C.S.C. Questionnaire for the study of chronic bronchitis and pulmonary emphysema" and underwent a chest X-ray and spirometry to measure FVC, FEV1 and Vmax 50. The prevalence of functional impairment and chronic bronchitis was higher in the foundry workers than in the group of non-exposed workers. A statistical standardization was made of the effect of age and smoking thus accentuating the effect of exposure. The results are compared with the data obtained by other epidemiologic studies on working populations exposed to a similar risk.

Adolescent↗